Zusammenfassung der Ressource
hyperlipidaemia
- a major risk factor
for coronary heart
disease
- IDn & Rx
during
childhood
may delay
onset of
CVD in
later life
- screen kids if at increased risk
- parent or grandparent
w/ hx of CHD before
55 years
- fam hx of lipid disorder
- if high serum cholesterol (i.e. >5.3 mmol/L)
on random testing
- measure triglyceride, LDL & HDL
- secondary causes
- obesity
- hypothyroidism
- diabetes mellitus
- nephrotic syn
- obstructive jaundice
- familial hypercholesterolaemia
- autosomal
dominant
- pathology
- defect in LDL receptor
- incidence
- 1 in 500
- associations
- premature
coronary heart
disease
- occurs in 50% by 50 years in
males and by 60 years in
females
- clinical features
- xanthomata
- skin
- tendon
- uncommon
in
childhood
- Mx
- drug therapy
- age= 10
years or more
- fam hx of
premature CHD
(< 55 yrs old)
- evidence of
tissue lipid
deposition
- xanthomata
- bruits
- non-lipid
risk factors
- eg. diabetes
- bile acid
sequestrants
- moderately
effective
- compliance
issues
- statins
(HMG-CoA
reductase
inhibitors)
- effective
- no -ve effects on
growth, maturation
or endocrine
function
- fenofibrate (fibrate)
- well
tolerated-kids
& teens
- homozygous genotype
- very rare
- very severe
- xanthomata
in childhood
- cardiovascular disease in the
20s
- refer to specialist centre
- Mx
- drug
- response varies acc to gene mutation
- liver transplant