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470698
Adrenal cortical insufficiency
Description
Paediatrics (Endocrine & metabolic) Mind Map on Adrenal cortical insufficiency, created by v.djabatey on 08/01/2014.
No tags specified
endocrine & metabolic
paediatrics
paediatrics
endocrine & metabolic
Mind Map by
v.djabatey
, updated more than 1 year ago
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Created by
v.djabatey
over 10 years ago
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Resource summary
Adrenal cortical insufficiency
congenital adrenal hyperplasia
the commonest non-iatrogenic cause of not enough cortisol & mineralocorticoid secretion
primary ACI (Addison's disease)
rare in children
may result from
an autoimmune process
sometimes in assoc w/ other autoimmune endocrine disorders
diabetes mellitus
hypothyroidism
hypoparathyroidism
haemorrhage/infarction
neonatal
meningococcal septicaemia
X-linked adrenoleucodystrophy
rare neurodegen metabolic disorder
TB (now rare)
secondary to
hypopituitarism from hypothalmic-pituitary disease
hypothalamic-pituitary-adrenal suppression
ff long term corticosteroid therapy
presentation
infants
acute presentation
salt-losing crisis
hypotension
and/or hypoglycaemia
dehydration ff a gastroenteritis-like illness
child recovers until next episode
older children
chronic ill health
pigmentation
e.g. buccal
salt-craving
Diagnosis
U&E
low Na+
high K+
blood gas
metabolic acidosis
blood glucose
hypoglycaemia
low plasma cortisol
high plasma [ACTH]
except in hypopituitarism
ACTH (Synacthen) test
plasma [cortisol] remain low in
primary adrenal failure
long-standing pituitary/hypothalamic Addison's disease
normal response exclude adrenal cortical insufficiency
Mx
adrenal crisis
urgent Rx needed
iv saline w/ glucose
iv hydrocortisone
all at risk of this should wear a MedicAlert bracelet
long-term replacement
glucocorticoid & mineralocorticoid replacement
increase glucocorticoid dose by 3x during illness or for an op
teach pt to inject im hydrocortisone in an emergency
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