71865
Ionotropic receptors
- Examples
- Nicotinic acetylcholine receptors
- Glutamate receptors
- GABA receptors
- Nicotinic acetylcholine receptors
- Features
- Directly coupled to ion channels
- Activated by neurotransmitters
- Fast response
- Results in opening of pore
- Pentameric structure
- Directly coupled to ion channels
- 1. Neurotransmitter binds
- 2. Channel opens
- 3. Ions flow across membrane
- Metabotropic receptors
- Not directly coupled to their ion channels
- Transduce the signal via G proteins
- 1. Neurotransmitter binds
- 2. G protein is activated
- 3. G-protein subunits or intracellular messengers modulate ion channels
- 4. Ion channel opens
- 5. Ions flow across membrane
- Not directly coupled to their ion channels
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