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General /History of LTP/LTD
- Trisynaptic loop
- medial and lateral PP-DG granule cells - MFP-CA3pyramidal-SCCP-CA1 pyramidal-Out
- Associational commissural - CA3-CA3
- on to CA3
- Excitatory onto CA1 - MF, PP, AC
- Interneurons - GABA
- Extrinsic: ACH, 5HT, DA
- Excitatory onto CA1 - MF, PP, AC
- Associational commissural - CA3-CA3
- medial and lateral PP-DG granule cells - MFP-CA3pyramidal-SCCP-CA1 pyramidal-Out
- Most commonly studied: CA3-CA1 - electrophysiological recordings
- Synaptic Plasticity: change in functional coupling between discrete neuronal structures
- Developmental - hrs - lifetime
- Short-term - ms-mins
- Long-term - hrs, months, years
- Pathological: changed wiring
- Epilepsy/neuropathic pain
- Epilepsy/neuropathic pain
- Regenerative
- Rewiring after trauma if connection broken
- Rewiring after trauma if connection broken
- Developmental - hrs - lifetime
- why?
- Memory
- Addiction/reward
- Sensory - visual
- Network maintenance
- Network computation
- Pathology
- Memory
- How?
- Induction
- Expression
- Maintenance
- Extinction
- Pre-S
- VG-function - membrane potential
- Number of NT vesicles released
- Content of each vesicle
- No. of release sites
- VG-function - membrane potential
- Post S
- No. of receptors
- Receptor efficiency
- P(o)
- Single channel conductance
- P(o)
- Change in spine size/active zone No.
- Ionic gradient - Cl-, K+
- No. of receptors
- Trans-synaptic
- Change in NT clearance
- EC ion conc
- EC pH
- Change in NT clearance
- Induction
- Stages of LTP
- Early LTP - Protein Kinase dependent, protein synthesis and Transcription independent
- Late LTP - Protein Kinase, Protein synthesis and Transcription dependent - transcription
in soma - Ca2+ dependent 2nd messenger - CREB
- STP: NMDAr dependent but not PK or PS dependent
- Early LTP - Protein Kinase dependent, protein synthesis and Transcription independent
- Induction properties of LTP
- Associativity
- Induction is influenced by activity at other synapses
- If weak pathway input immediatly preceeds strong pathway input
then weak pathway (below cooperativity threshold) will be
potentaited too
- If weak pathway input immediatly preceeds strong pathway input
then weak pathway (below cooperativity threshold) will be
potentaited too
- Induction is influenced by activity at other synapses
- Co-operativity
- Cooperativity between afferent fibres - intensity threshold for LTP
- Need to stimulate enough fibres
- Need to stimulate enough fibres
- Cooperativity between afferent fibres - intensity threshold for LTP
- Input-specificity- potentiation only occurs at active synpases
- Homosynaptic
- only conditioned synapse expreses plasticity
- only conditioned synapse expreses plasticity
- Heterosynaptic
- Conditioned and some non-conditioned express plasticity
- Conditioned and some non-conditioned express plasticity
- Homosynaptic
- Goddard Lab - McNaughton et al 1978
- Associativity
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