74244
Induction of LTP
- NMDAR's critical mediators of Hebbian SP
- Co-incident detectors
- Activation of NMDArs - increase in IC Ca2+- activation of Ca2+ dependent signalling
- Co-incident detectors
- Calcium Hypothesis of SP induction
- Role of inhibition in controlling SP induction
- Hyperpolarisation prevents NMDAr function at RMP
- With HFS - Frequency dependent depression of Inhibition - loose inhibition
- GABA acts back on PreS GABAb autoreceptors on inhibitory Interneurons
- Decreases GABA release
- Allows LTP induction
- Allows LTP induction
- Released by GABAergic Interneurons onto CA1
- Decreases GABA release
- GABA acts back on PreS GABAb autoreceptors on inhibitory Interneurons
- Hyperpolarisation prevents NMDAr function at RMP
- NEUROMODULATORS!!!!
- ACh
- Regulates NMDAr function
- Buchanan et al 2010
- Regulates NMDAr function
- CANABINOIDS
- Synthesised post S
- Retrograde diffusion
- Act on Pre-S CB1 receptors
- GPCR'S
- GPCR'S
- 2-AG, Anamandide
- Decrease NT release
- Synthesised post S
- ACh
- Glial cells and SP
- Perea & Araque (2007)
- Activated by Glutamate
- Activation can alter SP
- Release Gliotransmitters
- Glutamate Transporters
- Very vulnerable to slicing - more than neurons
- Perea & Araque (2007)
- NON HEBBIAN SP induction
- MF-CA3 pyramidal
- Pre-S induction and Expression
- NMDA-independent LTP
- Pre-S induction and Expression
- Glutamatergic onto interneurons
- AMPAr = CA2+ permeable
- AMPAr = CA2+ permeable
- MF-CA3 pyramidal
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