74245
Glial Cells
- Have Glutamate transporters
Annotations:
- bind glu and remove it from cleft - cessation of Excitatory transmission
- Astrocytes -hindering diffusion of Glu and GABA in the EC space
- thus regulate intersynaptic communication between neighbouring synapses and hence overall volume transmission in the brain
- E.g. Glutamate spillover onto preS gp2/3 mGluRs on GABAergic synapses
- this would decrease GABA release
- Piet et al 2004
- this would decrease GABA release
- HFS - lots of GABA release
- Activates Pre-S GABAb receptors of Glutamatergic synapses
- Decreases Glu Release
- Decreases Glu Release
- Activates Pre-S GABAb receptors of Glutamatergic synapses
- E.g. Glutamate spillover onto preS gp2/3 mGluRs on GABAergic synapses
- thus regulate intersynaptic communication between neighbouring synapses and hence overall volume transmission in the brain
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