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PHSI3012 08-1 Cardiac Ischaemia

Gelöschter Nutzer 8 Fragen Aktualisiert am 23 Nov 2017

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  1. 1Atheroma starts as fatty and cellular infiltration of the endothelium. Later becomes larger, [blank_start]__________[blank_end] and [blank_start]__________[blank_end] and may block 80% of the XS of parts of the coronary arteries. (put them in alphabetic order)
    1. ACalcified
    2. BFibrosed
  2. 2What’s responsible for the drastically reduced force output in EARLY ischaemic failure?
    1. AChanges in pH
    2. BChanges in Pi
    3. CFailure of excitation-contaction coupling
    4. DLow ATP
  3. 3True or false: ROS = Reactive Oxygen Species.
    1. ARichtig
    2. BFalsch
  4. 4Why does early reperfusion cause complete recovery whereas late reperfusion does not?
    1. AOn reperfusion damage mitochondria produce Reactive Oxygen Species (ROS) from O2, which damage membrane and contractile proteins
    2. BCoupled exchanger theory causes Ca2+ overload which activates Ca2+-activated proteases and causes cell damage
    3. CBoth of the above
    4. D[none of the above]
  5. 5True or false: ROS can cause damage through protein modification whereby –SH groups are oxidised into –S-S- groups.
    1. ARichtig
    2. BFalsch
  6. 6True or false: ROS can cause damage through protein modification whereby –S-S- groups are oxidised into –SH groups.
    1. ARichtig
    2. BFalsch
  7. 7Excess ROS leads to specific mitochondrial damage in which the MPTP opens. MPTP = ??
    1. AMitochondrial Permeability Transition Pore
    2. BModification of Protein Transition Pore
    3. CMitochondrial Pore Transition Permeability
    4. DMitochondrial Pore Transition Protein
  8. 8When the MPTP opens, Oxidative phosphorylation [blank_start]__________[blank_end], mitochondrial contents leak out, and the cell will eventually die by necrosis.
    1. AStops
    2. BStarts
    3. CIncreases
    4. DDecreases

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Beschreibung
PHSI3012 08-1 Cardiac Ischaemia (T2L5)
Autor
Gelöschter Nutzer
Sprache
English
Aufrufe
27
Verlauf
Erstellt am 22 Nov 2017 · aktualisiert am 23 Nov 2017
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