Quiz
PHSI3012 08-1 Cardiac Ischaemia
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Questions in this quiz (8)
1Atheroma starts as fatty and cellular infiltration of the endothelium. Later becomes larger, [blank_start]__________[blank_end] and [blank_start]__________[blank_end] and may block 80% of the XS of parts of the coronary arteries. (put them in alphabetic order)
- ACalcified
- BFibrosed
2What’s responsible for the drastically reduced force output in EARLY ischaemic failure?
- AChanges in pH
- BChanges in Pi
- CFailure of excitation-contaction coupling
- DLow ATP
3True or false: ROS = Reactive Oxygen Species.
- ATrue
- BFalse
4Why does early reperfusion cause complete recovery whereas late reperfusion does not?
- AOn reperfusion damage mitochondria produce Reactive Oxygen Species (ROS) from O2, which damage membrane and contractile proteins
- BCoupled exchanger theory causes Ca2+ overload which activates Ca2+-activated proteases and causes cell damage
- CBoth of the above
- D[none of the above]
5True or false: ROS can cause damage through protein modification whereby –SH groups are oxidised into –S-S- groups.
- ATrue
- BFalse
6True or false: ROS can cause damage through protein modification whereby –S-S- groups are oxidised into –SH groups.
- ATrue
- BFalse
7Excess ROS leads to specific mitochondrial damage in which the MPTP opens. MPTP = ??
- AMitochondrial Permeability Transition Pore
- BModification of Protein Transition Pore
- CMitochondrial Pore Transition Permeability
- DMitochondrial Pore Transition Protein
8When the MPTP opens, Oxidative phosphorylation [blank_start]__________[blank_end], mitochondrial contents leak out, and the cell will eventually die by necrosis.
- AStops
- BStarts
- CIncreases
- DDecreases
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- PHSI3012 08-1 Cardiac Ischaemia (T2L5)
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- English
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- History
- Created on 22 Nov 2017 · updated on 23 Nov 2017
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