Karteikarten
Th1L04 Misfolded protein disorders
Karten in diesem Stapel (13)
- 1Sickle cell disease is due to which mutation resulting in abnormally folded haemoglobin (HbS)Glu -> Val
- 2The misfolded HbS results in what characteristicPolymerisation
- 3Polymerised haemoglobin have what characteristicsCrystallised chain structures which disrupt the membrane of red blood cells
- 4Alzheimer's disease is mostly likely the result of whatformation of stable aggregations of proteins and amyloid proteins forming plaques
- 5Creutzfeldt-Jakob's disease is the result of whatstable aggregations of proteins called prions
- 6What is a prionA protein that can fold in multiple, structurally distinct ways, at least one of which is transmissible to other prion proteins
- 7Where are proteins foundon the surface of cells
- 8Prion protein polymerisation results in conversion of normal PrPC into whatpathogenic form PrSC
- 9Polymerisation of the pathogenic form (PrPSC) in CJD forms whatfibrils (aggregates)
- 10Structure of normal prion proteins (PrPC)Alpha helical, susceptible to proteolysis
- 11Structure of pathogenic prion proteins (PrPSC)Beta sheet becomes present, protease resistant so it accumulates
Identical amino-acid sequence to normal prion protein - 12Neurological symptoms of CJD (5)Difficulties with walking, slurred speech, numbness, dizziness, visual problems
- 13Psychological symptoms of CJD (5)Severe depression, withdrawal, anxiety, irritability, insomnia
Informationen
- Beschreibung
- Der Nutzer hat seine Fachbereichs-Information gelöscht. Karteikarten am Th1L04 Misfolded protein disorders, erstellt von Gelöschter Nutzer am 26/08/2016.
- Erstellt von
- Gelöschter Nutzer · Aug 2016
- Aktualisiert
- 27 Aug 2016
- Aufrufe
- 11
- Verlauf
-
- Erstellt von Emma Allde · 16 Aug 2016
- Kopiert von Emma Allde · 26 Aug 2016
- Bewertung