Flashcards
Th1L04 Misfolded protein disorders
Flashcards do conjunto (13)
- 1Sickle cell disease is due to which mutation resulting in abnormally folded haemoglobin (HbS)Glu -> Val
- 2The misfolded HbS results in what characteristicPolymerisation
- 3Polymerised haemoglobin have what characteristicsCrystallised chain structures which disrupt the membrane of red blood cells
- 4Alzheimer's disease is mostly likely the result of whatformation of stable aggregations of proteins and amyloid proteins forming plaques
- 5Creutzfeldt-Jakob's disease is the result of whatstable aggregations of proteins called prions
- 6What is a prionA protein that can fold in multiple, structurally distinct ways, at least one of which is transmissible to other prion proteins
- 7Where are proteins foundon the surface of cells
- 8Prion protein polymerisation results in conversion of normal PrPC into whatpathogenic form PrSC
- 9Polymerisation of the pathogenic form (PrPSC) in CJD forms whatfibrils (aggregates)
- 10Structure of normal prion proteins (PrPC)Alpha helical, susceptible to proteolysis
- 11Structure of pathogenic prion proteins (PrPSC)Beta sheet becomes present, protease resistant so it accumulates
Identical amino-acid sequence to normal prion protein - 12Neurological symptoms of CJD (5)Difficulties with walking, slurred speech, numbness, dizziness, visual problems
- 13Psychological symptoms of CJD (5)Severe depression, withdrawal, anxiety, irritability, insomnia
Informações
- Descrição
- O usuário eliminou as informações de disciplina FlashCards sobre Th1L04 Misfolded protein disorders, criado por Usuário eliminado em 26-08-2016.
- Criado por
- Usuário eliminado · ago 2016
- Atualizado
- 27 ago 2016
- Visualizações
- 11
- Histórico
-
- Criado por Emma Allde · 16 ago 2016
- Copiado por Emma Allde · 26 ago 2016
- Avaliação