Fichas
Th1L04 Misfolded protein disorders
Fichas del conjunto (13)
- 1Sickle cell disease is due to which mutation resulting in abnormally folded haemoglobin (HbS)Glu -> Val
- 2The misfolded HbS results in what characteristicPolymerisation
- 3Polymerised haemoglobin have what characteristicsCrystallised chain structures which disrupt the membrane of red blood cells
- 4Alzheimer's disease is mostly likely the result of whatformation of stable aggregations of proteins and amyloid proteins forming plaques
- 5Creutzfeldt-Jakob's disease is the result of whatstable aggregations of proteins called prions
- 6What is a prionA protein that can fold in multiple, structurally distinct ways, at least one of which is transmissible to other prion proteins
- 7Where are proteins foundon the surface of cells
- 8Prion protein polymerisation results in conversion of normal PrPC into whatpathogenic form PrSC
- 9Polymerisation of the pathogenic form (PrPSC) in CJD forms whatfibrils (aggregates)
- 10Structure of normal prion proteins (PrPC)Alpha helical, susceptible to proteolysis
- 11Structure of pathogenic prion proteins (PrPSC)Beta sheet becomes present, protease resistant so it accumulates
Identical amino-acid sequence to normal prion protein - 12Neurological symptoms of CJD (5)Difficulties with walking, slurred speech, numbness, dizziness, visual problems
- 13Psychological symptoms of CJD (5)Severe depression, withdrawal, anxiety, irritability, insomnia
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- El usuario ha eliminado su información de asignaturas Fichas sobre Th1L04 Misfolded protein disorders, creado por Usuario eliminado el 26/08/2016.
- Creado por
- Usuario eliminado · ago 2016
- Actualizado
- 27 ago 2016
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- 11
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- Creado por Emma Allde · 16 ago 2016
- Copiado por Emma Allde · 26 ago 2016
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