AntiFungal, Antiviral and Antimycobacerial Drugs- Pharmacology- 4th Year- PMU

Beschreibung

AntiFungal, Antiviral and Antimycobacerial Drugs- Pharmacology- 4th Year- PMU
Med Student
Quiz von Med Student , aktualisiert more than 1 year ago
Med Student
Erstellt von Med Student vor mehr als 5 Jahre
213
3

Zusammenfassung der Ressource

Frage 1

Frage
Antifungals are:
Antworten
  • tetracyclines
  • imidazoles
  • echinocandims
  • triazols

Frage 2

Frage
Synthetic antifungal drugs are
Antworten
  • Nystatin
  • Itraconazole
  • Ketoconazole
  • Fluconazole

Frage 3

Frage
Antifungal antibiotics are:
Antworten
  • Nystatin
  • Tetracycline
  • Gentamycin
  • Amphotericin B

Frage 4

Frage
Azoles:
Antworten
  • are fungistatic
  • inhibit cell wall synthesis
  • inhibit ergosterol synthesis
  • inhibit hepatic CYP450 enzymes

Frage 5

Frage
lmidazoles are:
Antworten
  • Fluconazole and ltraconazole
  • Miconazole and Econazole
  • Given topically
  • Given systematically

Frage 6

Frage
Ketoconazole is:
Antworten
  • the only imidazole that can be given orally
  • used for treatment of bacterial skin infections
  • used topically for cutaneous fungal infections
  • used intravenously for treatment of systemic fungal infections

Frage 7

Frage
Fluconazole:
Antworten
  • it is non- steroidal anti-inflammatory drug
  • is triazole antifungal drug
  • is administered orally or intravenously
  • is excreted mainly unchanged with the urine

Frage 8

Frage
ADRs of azole antifungals are:
Antworten
  • hepatotoxicity
  • endocrine disorders
  • nephrotoxicity
  • nausea, vomiting

Frage 9

Frage
Point the correct statements for Nystatin:
Antworten
  • has fungistatic activity
  • causes gastrointestinal disturbances
  • is effective against Trichomonas vaginalis
  • is effective against Candida species

Frage 10

Frage
ADRs of Amphoteracin B are:
Antworten
  • renal impairment
  • hypokalemia
  • hypotension
  • liver impairment

Frage 11

Frage
Antiviral drugs act by following mechanisms
Antworten
  • inhibition of viral “uncoating”
  • inhibition of viral DNA or RNA synthesis
  • inhibition of viral proteases
  • inhibition of viral penetration into the cell

Frage 12

Frage
Point out the correct statements for Aciclovir:
Antworten
  • it inhibits viral DNA polymerase
  • it is used for “treatment of herpesvirus infections
  • it inhibits neuraminidase enzyme
  • can be applied topically, orally or intravenously

Frage 13

Frage
ADRs of Aciclovir are:
Antworten
  • hepatotoxicity
  • renal impairment
  • local irritation
  • encephalopathy (at high i.v. doses)

Frage 14

Frage
Drugs for prevention and treatment of flu are:
Antworten
  • Aciclovir (Zovirax)
  • Amantadin (Symmetrel)
  • Rimantadin (Flumadine)
  • Oseltamivir (Tamiflu)

Frage 15

Frage
Mechanism of action of Oseltamivir (Tamiflu) is
Antworten
  • interference with the function of the viral M2 protein
  • inhibition of specific neuraminidase enzyme
  • inhibition of reverse transcriptases
  • inhibition of proteases

Frage 16

Frage
For Amantadine and Rimantadine is true:
Antworten
  • resistance can develop rapidly
  • they are effective against both type A and type B influenza
  • they are effective against type A influenza viruses
  • they interfere with the function of the viral M2 protein and block uncoating of the Virus particles

Frage 17

Frage
Mechanisms of action of drugs for treatment of HIV infection are:
Antworten
  • inhibition of reverse transcriptase
  • inhibition of HIV protease
  • inhibition of HIV entry into the host cell
  • inhibition of the insertion of proviral DNA. into the host cell genome

Frage 18

Frage
Point out the correct statements for Zidovudin;
Antworten
  • it blocks HIV reverse transcriptase
  • it blocks HIV protease
  • it is a nucleoside analogue
  • it can cause anemia and neutropenia

Frage 19

Frage
ADRS of Nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs) are:
Antworten
  • peripheral neuropathy
  • pancreatitis
  • polymyositis
  • glaucoma

Frage 20

Frage
HIV protease inhibitors are:
Antworten
  • Zidovudin
  • Indinavir
  • Ritonavir
  • Aciclovir

Frage 21

Frage
For HIV protease inhibitors is true:
Antworten
  • protease inhibition prevents maturation of the viral particles
  • they are enzyme inducers
  • they are enzyme inhibitors
  • they are combined with other antiretroviral drugs in the treatment of HIV infection

Frage 22

Frage
ADRs of HIV protease inhibitors are:
Antworten
  • hyperlipidaemia
  • insulin resistance and hyperglycaemia
  • hypoglycaemia
  • fat redistribution

Frage 23

Frage
Inhibitor of both hepatitis B virus (HBV) and HIV reverse transcriptases is:
Antworten
  • Zidovudin
  • Lamivudin
  • Aciclovir
  • lndinavir

Frage 24

Frage
Protease inhibitor for treatment of chronic hepatitis C infection is:
Antworten
  • Aciclovir
  • Telaprevir
  • Zidovudin
  • Oseltamivir

Frage 25

Frage
Antimycobacterial drugs are:
Antworten
  • Rifampicin
  • Isoniazid
  • Ethambutol
  • Amoxicillin

Frage 26

Frage
Rifampicin (Rifampin):
Antworten
  • is bactericidal antibiotic with antimycobacterial activity
  • is antiviral drug
  • is broad spectrum antibiotic
  • is enzyme inducer

Frage 27

Frage
Mechanism of action of Rifampicin (Rifampin) is
Antworten
  • inhibition of cell wall synthesis
  • inhibition of 50 S ribosomal subunit
  • inhibition of DNA-dependent RNA polymerase
  • increased cell membrane permeability

Frage 28

Frage
ADRs of Rifampicin (Rifampin) are:
Antworten
  • heart failure
  • orange-red color of urine and other secretions
  • hepatotoxicity
  • hypoglycaemia

Frage 29

Frage
Point out the correct statements for lsoniazid:
Antworten
  • inhibits the synthesis of essential for mycobacteria mycolic acid
  • it is metabolized by, acetylation
  • it is specific for treatment of M. Tuberculosis
  • it is active against broad spectrum of bacteria

Frage 30

Frage
ADRs of lsoniazld are:
Antworten
  • renal impairment
  • peripheral neuropathy
  • convulsions
  • hepatitis

Frage 31

Frage
lsoniazid-induced peripheral neuropathy can be avoided by:
Antworten
  • supplementation with vitamin B1
  • supplementation with vitamin A
  • supplementation with vitamin B6
  • supplementation with vitamin B12

Frage 32

Frage
ADRs of Pyrazinamide are:
Antworten
  • hepatotoxicity
  • arrhythmia
  • hyperuricaemia
  • hypoglycaemia

Frage 33

Frage
Ethambutol:
Antworten
  • is bacteriostatic antimycobacterial drug
  • may cause liver failure
  • may cause optic neuritis
  • inhibits synthesis of the mycobacterial cell wall
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