Quiz
pharmacokinetics
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Fragen in diesem Quiz (23)
1what is the correct equation for bioavailability
- Aamount of drug in general circulation/ amount of drug administered
- Bamount of drug administered/ amount of drug in general circulation
- Camount of drug orally taken/ amount of drug in general circulation
- Damount of drug in general circulation/ amount of drug taken orally
2which of the following does facilitated diffusion depend on
- Aconcentration gradient and thickness of barrier
- Bconcentration gradient
- Ctransprotein, saturability, structural selectivity and ATP dependance
- Dthickness of barrier
3which of the following does active transport depend on
- Aconcentration gradient and thickness of barrier
- Bconcentration gradient
- Ctransprotein, saturability, structural selectivity and ATP dependance
- Dthickness of barrier
4when talking about pharmacokinetics which is the correct order of the following
- Aabsorption, distribution, metabolism and excretion
- Bdistribution, metabolism, absorption and excretion
- Cabsorption, metabolism, distribution and excretion
- Dexcretion, absorption, metabolism and distribution
5what is the correct definition for bio availability
- Aamount of drug available to the body to produce a therapeutic effect
- Bamount of drug taken to the body to produce a therapeutic effect
- Camount of drug metabolized in the body to produce a therapeutic effect
- Damount of drug available to the body to produce a negative effect
6which of the following properties of the drug would allow it to be absorbed faster
- Asmall molecule, lipid soluble and non-ionized
- Bsmall molecule, lipid soluble and ionized
- Csmall molecule, water soluble and non-ionized
- Dsmall molecule, water soluble and ionized
7when taking penicillin (an acidic drug) where would you expect it to be absorbed
- Astomach
- Blarge intestine
- Csmall intestine
- Dliver
8when taking a basic drug where would you expect it to be absorbed
- Aliver
- Bstomach
- Clarge intestine
- Dsmall intestine
9what molecule would a acidic drug such as aspirin bind to
- Aalbumin
- BA1-acidic glycoproteins
- CGLUT-1
- DA2-acidic glycoproteins
10what molecule would a basic drug bind on to
- Aalbumin
- BGLUT-1
- CA1-acidic glycoproteins
- DA2-acidic glycoproteins
11complete the text based on plasma protein binding in the distribution stage:
1) [blank_start]insoluble[blank_end] substances travel around the body via binding proteins
2) binding proteins have a [blank_start]ampiphatic[blank_end] nature
3) binding is [blank_start]reversible[blank_end]
4) generally acidic drugs bind to [blank_start]albumin[blank_end] and basic drugs bind to [blank_start]A1-acidic glycoproteins[blank_end]
5) [blank_start]globin[blank_end] levels [blank_start]increase[blank_end] with age- Ainsoluble
- Bsoluble
- Campiphatic
- Dlipophilic
- Elipophopic
- Freversible
- Girreversible
- Halbumin
- IA1-acidic glycoproteins
- Jglobin
- KGABA
- LA2-acidic glycoproteins
- Mincrease
- Ndecrease
12when talking about distribution in pharmacokinetics which of the following statements are true
- Athe degree which a drug is likely to accumulate in the tissue is dependent on the lipophilicity and local blood flow to the tissue
- Bthe degree which a drug is likely to accumulate in the tissue is dependent on the hydrophilicity and local blood flow to the tissue
- Cthe degree which a drug is likely to accumulate in the tissue is dependent on the lipophobic properties and general blood flow
- Dthe degree which a drug is likely to accumulate in the tissue is dependent on the hydrophobic properties and general blood flow
13the role of the liver in distribution:
after the drug is absorbed by the [blank_start]GI tract[blank_end] it is taken up in the [blank_start]hepatic portal system[blank_end]. Most of the drugs absorbed in the system except for [blank_start]lipids[blank_end] that instead are absorbed by the [blank_start]lymphatic system[blank_end] and delivered into the blood by the [blank_start]thoracic[blank_end] duct into the [blank_start]superior vena cava[blank_end]- AGI tract
- Bhepatic portal system
- Clipids
- Dproteins
- Elymphatic system
- Fthoracic
- Gsubclavian
- Hinternal mammary
- Isuperior vena cava
- Jinferior vena cava
- Kaorta
14what is the correct definition for the volume of distribution
- Atheoretic volume in litres into which a drug dissolves to produce the plasma concentration observed at steady state
- Btheoretic volume in millilitres into which a drug dissolves to produce the plasma concentration observed at steady state
- Ctheoretic volume in litres into which a drug metabolises to produce the plasma concentration observed at steady state
- Dtheoretic volume in litres into which a drug dissolves to produce the plasma concentration observed at end state
15what is the correct equation for volume of distribution
- Adose/ steady state of plasma concentration
- Bsteady state of plasma concentration/ dose
- Cdose/ total plasma volume
- Dtotal plasma volume/ dose
16which of the following statements are true about the metabolism stage
- Amost drugs are hydrophillic
- Bonly water soluble molecules can be eliminated from the body
- Cdrugs in the lipophillic state are excreted without modification
- Dthere are 4 phases to this stage
17phases of metabolism of drugs:
PHASE 1:
enzymes modify the drug chemically by processes such as oxidation, reduction, hydrolosis or the removal or addition of an active group. oxidation is carried out by [blank_start]cytochrome P450[blank_end].
PHASE 2:
includes [blank_start]conjugation[blank_end] of a drug or a phase 1 metabolite with a [blank_start]polar[blank_end] group to render it possible for excretion. principle sites for metabolism are the [blank_start]liver[blank_end] and kidney. [blank_start]deconjugation[blank_end] of the drug by enzymes is called the [blank_start]enterohepatic cycle[blank_end].
the mechanisms involved are:
competition, inhibition and induction- Acytochrome P450
- Bcytochrome P540
- Ccytochrome P45
- Dconjugation
- Epolar
- Fnon-polar
- Gliver
- Hstomach
- Icolon
- Jdeconjugation
- Kenterohepatic cycle
- Linterohepatic cycle
18what is the correct definition for the therapeutic index
- Aratio between toxic dose and therapeutic dose of a drug, used as a measure of relative safety of a drug
- Bratio between toxic dose and steady state of a drug, used as a measure of relative safety of a drug
- Cratio between steady state and therapeutic dose of a drug, used as a measure of relative safety of a drug
- Da measure of a the toxic volume a drug, used as a measure of relative safety of a drug
19which of the following is true about first order kinetics
- Aconstant fraction of drug is eliminated per unit of time
- Brate of drug elimination is proportional to drug plasma concentration
- Cindependent of dose
- Ddependent on dose
- Econstant rate of drug eliminated per unit of time
- Frate of drug elimination is independent of drug plasma concentration
20what is the correct equation for the therapeutic index
- ATD50/ED50
- BED50/TD50
- CTD50/VD50
- DVD50/TD50
21which of the following is true about zero order kinetics
- Aconstant amount of drug eliminated per unit of time
- Brate of drug elimination is independent of drug plasma concentration
- Cdependent on drug dose
- Dconstant fraction of drug is eliminated per unit of time
- Erate of drug elimination is proportional to drug plasma concentration
- Findependent of drug dose
22complete the image
- Azero order
- Bfirst order
23what are the assumptions you need to consider when using drug elimination half lives
- Ainstant renal and hepatic function
- Btime needed to reach steady state plasma concentration after single dose is 4-5 T1/2
- Ccardiac output remains the same whilst the drug is administered
- Dnormal cardiac and pulmonary function
- EBMI of patient
Informationen
- Beschreibung
- Quiz on pharmacokinetics , created by David alibhai on 08/04/2019.
- Autor
- David alibhai
- Sprache
- English
- Aufrufe
- 9
- Schlagwörter
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