Clinical Pharmacology Final MCQs- 5th Year PMU

Question

Drugs half-life is an index for

Answer 1

the route of administration of the drug

Answer 2

the duration of the drug effect when there is a relationship between it and plasma concentrations

Answer 3

time to reach steady-state plasma concentration after repeated administration

Answer 4

determination of dose interval

Answer 5

drugs withdifferent half-life

Answer 6

drugs for etiotropic and symptomatic treatment

Answer 7

drugs with narrow therapeutic window

Answer 8

drugs affecting different pathogenic mechanisms

Answer 9

spontaneous reporting

Answer 10

observation studies

Answer 11

family doctors

Answer 12

population statistics

Answer 13

Erythromycin

Answer 14

Sex steroids

Answer 15

Penicillins

Answer 16

Oral anticoagulants

Answer 17

decreased excretion

Answer 18

decreased metabolism

Answer 19

decreased volume of distribution

Answer 20

increased volume of distribution

Answer 21

chronic renal failure

Answer 22

improper use of the drug formulation

Answer 23

bad quality of the drug substance

Answer 24

participating in treatment

Answer 25

first application of a new substance to healthy volunteers

Answer 26

first application of a new substance to patients

Answer 27

efficacy and safety in a large number of patients

Answer 28

post-marketing surveillance in thousands of patients

Answer 29

theophyllin

Answer 30

phenobarbital

Answer 31

carbamazepin

Answer 32

amoxicillin

Answer 33

decreased effect

Answer 34

increased effect

Answer 35

development of adverse drug reactions

Answer 36

avitaminosis

Answer 37

allergic drug reaction

Answer 38

drug form, without active substance

Answer 39

method for treatment of acute pain

Answer 40

drug tolerance

Answer 41

Allergic drug reaction

Answer 42

Analgesic method

Answer 43

Adverse drug reaction, caused by placebo

Answer 44

CNS depression

Answer 45

open trial

Answer 46

blind trial

Answer 47

placebo trial

Answer 48

double blind trial

Answer 49

half- life

Answer 50

drugs interactions

Answer 51

bioavailabillity

Answer 52

the value of the pharmacological effect

Answer 53

increased pharmacological effect

Answer 54

decreased risk of toxicity

Answer 55

decreased efficacy of the treatment

Answer 56

development of unpredictable drug effects

Answer 57

increases drugs metabolism

Answer 58

decreases drug metabolism

Answer 59

decreases plasma concentrations of methylxanthines

Answer 60

doesn’t change drugs metabolism

Answer 61

method for neuroleptanalgesy

Answer 62

used, when there is relationship between plasma concentrations and drug effect

Answer 63

used for drugs with narrow therapeutic window

Answer 64

used for drugs with long half- live

Answer 65

first application of a new substance to healthy volunteers

Answer 66

first application of a new substance to patients

Answer 67

efficacy and safety in a large number of patients

Answer 68

post-marketing surveillance in thou-sands of patients

Answer 69

drugs excretion

Answer 70

determination of maintaining dose of the drugs

Answer 71

drugs absorption

Answer 72

effects of the drugs on the heart

Answer 73

arrhythmias

Answer 74

headache, fatigue, seizures

Answer 75

decreased diuresis

Answer 76

bradycardia

Answer 77

Antimuscarinic drugs

Answer 78

β2-mimetics

Answer 79

Methylxanthines

Answer 80

H2-blockers

Answer 81

Cardiac glycosides

Answer 82

ACE- inhibitors

Answer 83

Calcium channel blockers

Answer 84

osmotic diuretics

Answer 85

thiazide diuretics

Answer 86

loop diuretics

Answer 87

aldosterone antagonists

Answer 88

bradycardic effect

Answer 89

coronary vessels dilation

Answer 90

reduced oxygen demand of the heart

Answer 91

inhibition of platelet aggregation

Answer 92

tachycardia

Answer 93

bradycardia

Answer 94

swelling of ankles

Answer 95

flushing and headache

Answer 96

Calcium channel blockers

Answer 97

β-blockers

Answer 98

Organic nitrates

Answer 99

Metabolotropic drugs

Answer 100

Furosemide

Answer 101

Nitroprusside

Answer 102

antacids drugs

Answer 103

anti-secretion drugs

Answer 104

gastro-duodenal protectors

Answer 105

drugs against HP infections

Answer 106

sodium salts

Answer 107

calcium salts

Answer 108

aluminium salts

Answer 109

magnesium salts

Answer 110

binds to specific opioid receptors

Answer 111

cause dependence and abuse

Answer 112

in high doses suppress the respiratory center

Answer 113

showed withdrawal in long term therapy

Answer 114

antipyretic

Answer 115

anti-inflammatory

Answer 116

cough suppressants

Answer 117

Ureidopenicillins

Answer 118

Narrow spectrum penicillins

Answer 119

Macrolides

Answer 120

First generation cephalosporins

Answer 121

Penicillins

Answer 122

Quinolones

Answer 123

Macrolides

Answer 124

Aminoglycosides

Answer 125

clinical- laboratory indexes

Answer 126

instrumental investigations - ECG: EMG; MRT etc

Answer 127

disease improvement

Answer 128

decreased mortality rate

Answer 129

increased sensitivity to drugs suppressing central nervous system

Answer 130

decreased sensitivity to drugs suppressing central nervous system

Answer 131

paradoxal reactions are observed

Answer 132

adverse drug reactions are more frequent

Answer 133

blood concentration of the drug 2 hours after administration

Answer 134

blood concentration of the drug after repeated administration when there is a balance between absorbtion and excretion

Answer 135

blood concentration of the drug after it has been ceased

Answer 136

blood concentration of the drug during its absorbtion

Answer 137

dose regimen with many drugs with frequent administration

Answer 138

a large number of drugs

Answer 139

lack of information for the treatment

Answer 140

the drug must be taken once daily

Answer 141

first application of a new substance to healthy volunteers

Answer 142

first application of a new substance to patients

Answer 143

efficacy and safety in a large number of patients

Answer 144

post-marketing surveillance in thousands of patients

Answer 145

amount of drug, that reaches systemic circulation

Answer 146

blood plasma volume from which the drug is eliminated for defined period of time

Answer 147

steady- state plasma concentration

Answer 148

withdrawal syndrome

Answer 149

bradycardia

Answer 150

thyreotoxicosis

Answer 151

hypertension

Answer 152

strong acute pain as some crisis

Answer 153

chronic pain in cancer patients

Answer 154

inhibition of COX enzymes

Answer 155

inhibition of phosphodiesterase

Answer 156

bind to dopamine receptors

Answer 157

bind to opioid receptors

Answer 158

bactericidal

Answer 159

bacteriostatic

Answer 160

carbapenemes

Answer 161

glycopeptides

Answer 162

Prednisone

Answer 163

Budesonide

Answer 164

Methylprednisolone

Answer 165

Prednisolone

Answer 166

As earlier as having diagnose

Answer 167

ACE inhibitors are recommended as first line drugs

Answer 168

The very low doses are preferred

Answer 169

Start with high doses

Answer 170

Bradycardia

Answer 171

Hypertension

Answer 172

propranolol

Answer 173

furosemide

Answer 174

angioedema

Answer 175

hyperlipidemia

Answer 176

hyperglycemia

Answer 177

decrease of blood volume

Answer 178

decreased sensitivity of vessels to vasoconstrictors

Answer 179

reduced activity of renin-angiotensin system

Answer 180

decreased peripheral vascular tone

Answer 181

Omeprazole

Answer 182

Rabeprazole

Answer 183

Mizoprostol

Answer 184

Lansoprazole

Answer 185

Sucralphate

Answer 186

Misoprostol

Answer 187

Probiotics

Answer 188

Colloidal bismuths salts

Answer 189

traumatic shock

Answer 190

acute myocardial infarction

Answer 191

malignant pain

Answer 192

neuropathic pain

Answer 193

radiculitis

Answer 194

neuropathic pain

Answer 195

acute migraine

Answer 196

prevention of migraine

Answer 197

cancer pain

Answer 198

Ceftriaxone (Rocephin)

Answer 199

Gentamycin

Answer 200

Rifampicin (Tubocin)

Answer 201

Doxyxyclin (Vibramycin)

Answer 202

ototoxicity

Answer 203

nephrotoxicity

Answer 204

gastrointestinal problems

Answer 205

liver toxicity

Answer 206

early stage of chronic cardiac failure

Answer 207

supra-ventricular fibrillations

Answer 208

decrease the mortality rate

Answer 209

tachycardia

Answer 210

bradycardia

Answer 211

constipation

Answer 212

heart failure

Answer 213

decreased preload of the heart

Answer 214

improved oxygen supply

Answer 215

reduced afterload of the heart

Answer 216

dilation of coronary vessels

Answer 217

the difficulties to fall asleep

Answer 218

easy fall asleep

Answer 219

awakening during the night

Answer 220

early awake

Answer 221

Salbutamol

Answer 222

Salmeterol

Answer 223

Terbutaline

Answer 224

clinical outcomes

Answer 225

costs — direct and indirect

Answer 226

functional status pf patient

Answer 227

overall patient satisfaction

Answer 228

cost minimization analysis

Answer 229

cost effectiveness analysis

Answer 230

cost utility analysis

Answer 231

cost consequence analysis

Answer 232

ACE inhibitors

Answer 233

Cardiac glycosides

Answer 234

β-blockers

Answer 235

Organic nitrates

Answer 236

Corticosteroids

Answer 237

β-blockers

Answer 238

Leukotriene inhibitors

Answer 239

MAO inhibitors

Answer 240

β2-mimetics

Answer 241

Corticosteroids

Answer 242

Leukotriene antagonists

Answer 243

good tolerability

Answer 244

better compliance

Answer 245

complex hemodynamic improving effect

Answer 246

less tolerated and low compliance in comparison with ACE inhibitors

Answer 247

Cardiac glycosides

Answer 248

β-blockers

Answer 249

Organic nitrates

Answer 250

Calcium channel blockers

Answer 251

ACE inhibitors

Answer 252

Angiotensin receptor blockers

Answer 253

β-blockers

Answer 254

hyperglycemia

Answer 255

hyperuricemia

Answer 256

hypopotassiemia

Answer 257

hyperpotassiamia

Answer 258

decreased absorption of some antibiotics as tetracyclines, isoniazid, ciprofloxacin

Answer 259

decreased absorption of some drugs as digoxin, quinidine, theophylline, NSAIDs

Answer 260

increased absorption of some antibiotics as tetracyclines, isoniazid, ciprofloxacin

Answer 261

increased absorption of other drugs as digoxin, quinidine, theophylline, warfarin

Answer 262

Bismuth salts

Answer 263

Misoprostol

Answer 264

Proton pump inhibitors

Answer 265

Antacid drugs

Answer 266

patients with cancer pain

Answer 267

patients with crisis

Answer 268

patients with toothache

Answer 269

patients with headache

Answer 270

cardio-toxicity

Answer 271

epidermal necrolysis

Answer 272

peptic ulcer

Answer 273

depressed fertility

Answer 274

sleepiness

Answer 275

fatigue and dizziness

Answer 276

hyperglycemia

Answer 277

paresthesias

Answer 278

Ureidopenicillins

Answer 279

Narrow spectrum penicillins

Answer 280

Macrolides

Answer 281

First generation cephalosporins

Answer 282

liver damage

Answer 283

ototoxicity

Answer 284

nephrotoxicity

Answer 285

teeth and bone damage

Answer 286

gastro-intestinal

Answer 287

damage of the joints

Answer 288

increase of intraocular pressure

Answer 289

provoke seizures in patients with epilepsy

Answer 290

unpredictable

Answer 291

pharmacokinetic

Answer 292

pharmacodynamic

Answer 293

pharmaceutical

Answer 294

acetylation

Answer 295

hydrolysis

Answer 296

red cells enzyme defects

Answer 297

tachycardia

Answer 298

hyperglycemia

Answer 299

hypoglycemia

Answer 300

Calcium channel blockers

Answer 301

Organic nitrates

Answer 302

β-blockers

Answer 303

tachycardia

Answer 304

hypertension

Answer 305

headache and flushing

Answer 306

peptic ulcer

Answer 307

liver insufficiency

Answer 308

kidney insufficiency

Answer 309

hypertension

Answer 310

drug tolerance and dependence

Answer 311

slowed reflex time and myorelaxation

Answer 312

morning sleepiness for the drugs which form active metabolites

Answer 313

Beta-blockers

Answer 314

Opioid analgesics

Answer 315

NSAIDs and spasmolytics

Answer 316

NSAIDs and coffein

Answer 317

Opioid analgesics and NSAIDs

Answer 318

Analgesics and calcium channel antagonists

Answer 319

pregnant women

Answer 320

breast feeding mothers

Answer 321

children under 12 years of age

Answer 322

patients with kidney failure

Answer 323

bone-marrow suppression

Answer 324

kidney damage in high doses

Answer 325

heart failure

Answer 326

hypoglycemia

Answer 327

hyperglycemia

Answer 328

reduced calcium absorption

Answer 329

increased protein catabolism

Answer 330

β-blockers

Answer 331

Angiotensin receptors blockers

Answer 332

α-blockers

Answer 333

β-blocker + α-blocker

Answer 334

β-blocker + diuretic

Answer 335

α-blocker + ACE inhibitor

Answer 336

Calcium channel antagonists + Diuretic

Answer 337

tachycardia

Answer 338

flush syndrome

Answer 339

orthostatic hypotension

Answer 340

traumatic shock

Answer 341

acute myocardial infarction

Answer 342

malignant pain

Answer 343

neuropathic pain

Answer 344

Budesonide

Answer 345

Dexamethasone

Answer 346

Fluticasone

Answer 347

Beclomethasone

Answer 348

Nitroprusside

Answer 349

Propranolol

Answer 350

Methyldopa

Answer 351

α2-agonists

Answer 352

α1-blockers

Answer 353

M-cholinolytics

Answer 354

Antihistamine drugs

Answer 355

Proton pump inhibitors

Answer 356

H2-histamine blockers in stomach mucosa

Answer 357

M3-cholinergic blockers in stomach mucosa cells

Answer 358

COX inhibitors

Answer 359

proton pump inhibitors

Answer 360

colloidal bismuthi salts

Answer 361

histamine blockers

Answer 362

antibacterial drugs

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Clinical Pharmacology Final MCQs- 5th Year PMU

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