3126972
Frage 1
Frage
All of the following are correctly matched except?
Antworten
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Type I HSR - IgE mediated
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Type II HSR - IgA mediated
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Type III HSR - Immune complex - IgG mediated
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Type IV HSR - Cell mediated
Frage 2
Frage
All of the following are true about hygiene hypothesis except
Antworten
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Excessive hygeine
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Overuse of antibiotics
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Not vaccinating the child
Frage 3
Frage
All of the following are components of a typical adaptive response to an helminthic infection except
Antworten
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CDH4 Th1 cells
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Cytokines - IL 3,4,5,9,10,13
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antibodies IgE and IgG 1 and 4
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Effector cells such as eosinophils, basophils and mast cells
Frage 4
Frage
The main components of type I HSR are neutrophils and lymphocytes
Antworten
- True
- False
Frage 5
Frage
Sensitization to antigen involves class switching to IgE production on first contact with an allergen
Antworten
- True
- False
Frage 6
Frage
All of the following are stages in HSR I except
Antworten
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Initial exposure to immunogen which results in the production of reactive B and T cells - no symptoms
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B cell - T cell interaction - antigen activation of Th2 cells
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Production of IL 4 + IL 13
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Production of IgE
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Binding of IgE to Fc Epsilon Receptor and activation/sensitization of mast cell and release of mediators
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None of the above
Frage 7
Frage
The following is true about HSR I immediate and late response
Antworten
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Within minutes mast cell + Basophils will release histamine and serotonin causing wheal and flare
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In hours Eosinophils +Th2 will release second wave of mediators prostaglandis and leukotrienes
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Both are correct
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None of the above
Frage 8
Frage
Intrinsic asthma is Type I HSR reaction
Antworten
- True
- False
Frage 9
Frage
The Primary method for diagnosing HSR I is by skin testing, with the characteristic response being "wheal and flare" reaction within minutes
Antworten
- True
- False
Frage 10
Frage
RAST detects IgG anti-allergen in patient's serum
Antworten
- True
- False
Frage 11
Frage
All of the following are used as treatment strategies for HSR I
Antworten
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Allergen avoidance
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Correct Th1/Th2 imbalance (not clinically feasible)
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Block mediators either with antihistamine, lipoxygenase inhibition or steroid use
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Correct isotype switch to IgE
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Prevent IgE binding to mast cells to prevent IgE mediated degranulation
Frage 12
Frage
Epinephrine is the main treatment for anaphylaxis - true or false
Antworten
- True
- False
Frage 13
Frage
In desensitization treatment the allergen binds to IgG thereby preventing IgE mediated response - true or false
Antworten
- True
- False
Frage 14
Frage
Omalizumab is a mab that binds to Fc region of IgE thereby blocking the arming of mast cells - true or false
Antworten
- True
- False
Frage 15
Frage
All of the following are true about HSR II except
Antworten
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HSR II is mediated by IgG or IgM not IgE
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HSR II the antibodies bind to the self antigen on cell membranes and extracellular matrix
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HSR II makes autoreactive antibodies
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HSR II activates the alternate complement pathway
Frage 16
Frage
All of the following are mechanisms for cell damage in HSR II except?
Antworten
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recruitment of neutrophils - causing tissue injury and inflammation
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Opsonization and Phagocytosis
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Interfere with cellular functions - either block or stimulate cell receptors
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All of the above
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None of the above
Frage 17
Frage
All of the following are HSR II reactions except
Antworten
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Hemolytic disease of the newborn
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Blood transfusion reactions
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Penicillin reaction
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Extrinsic asthma
Frage 18
Frage
All of the following are true regarding Hemolytic disease of the newborn (HDNB) except
Antworten
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Seen when mother is Rh+ and baby is Rh-
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Mother is O type blood group and baby A,B or AB
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Prevention is by giving Rhogam to the mother
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None of the above
Frage 19
Frage
All of the following are non cytotoxic type II HSR diseases except
Antworten
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Myasthenia gravis
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NDIIM
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Graves disease
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Pernicious anemia
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Penicillin allergy
Frage 20
Frage
All of the following are cytotoxic HSR II except?
Antworten
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Erythroblastosis fetalis (Hemolytic disease of the newborn)
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PCN reaction
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Rheumatic fever
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Autoimmune thrombocytopenic purpura
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Goodpasture syndrome
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Grave's disease
Frage 21
Frage
Type III HSR - damaged tissues are innocent bystanders when a circulating (soluble antigen) immune complex becomes deposited in the tissues - true or false
Antworten
- True
- False
Frage 22
Frage
When immune complexes (ICs) exceed disposal the net result is inflammation locally or systemically - true or false
Antworten
- True
- False
Frage 23
Frage
All of the following are Type III HSR except
Antworten
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Serum sickness
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Farmer's lung (Arthus reaction)
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SLE
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Post Streptococcal glomerulonephritis (PSGN)
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None of the above
Frage 24
Frage
Lumpy bumpy pattern of nephritis is characteristic of PSGN - true or false
Antworten
- True
- False
Frage 25
Frage
All of the following are true about Arthus reaction except?
Antworten
-
Farmer's lung is an example of Arthus reaction
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Arthus reaction is used in the skin testing of HSR III
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Arthus reactions are visualized in the skin
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none of the above
Frage 26
Frage
All of the following are true about delayed type IV HSR except?
Antworten
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Starts 49-72 hours after antigen exposure
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T cell release cytokines that activate macrophages resulting in cell damage
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B cells form antibodies that are delayed in their response hence called delayed HSR
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Mediated by Th1 cells and CD8+ cytotoxic T cells
Frage 27
Frage
HSR IV is an inappropriate manifestation of DTH response that normally protects against intracellular bacterial and fungal infections - true or false
Antworten
- True
- False
Frage 28
Frage
All of the following are examples of IV HSR except
Antworten
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PPD
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Poison ivy dermatitis
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contact dermatitis due to nickel exposure
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Celiac disease
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PSGN
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