562906
Frage 1
Frage
In aerobic respiration, where is the pyruvate dehydrogenase complex located in Eukaryotes?
Antworten
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Inner membrane of mitochondria
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Outer membrane of mitochondria
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Matrix of mitochondria
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Cytosol of the cell
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Intermembrane space of mitochondria
Frage 2
Frage
What activates pyruvate dehydrogenase complex?
Antworten
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phosphorylation
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dephosphorylation
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acetyl CoA
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protein kinase
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Glucagon in adipocytes and liver
Frage 3
Frage
What coenzymes are necessary for pyruvate dehydrogenase complex?
Antworten
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nicotinamide adenine dinucleotide, flavin adenine dinucleotide, coenzme A-SH, lipoic acid, thiamine pyrophosphate
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PDH, NAD+, FAD, TPP, lipoic acid
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pyruvate dehydrogenase, dihydrolipoyl transacetylase, dihydrolipoyl dehydrogenase
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pyruvate decarboxylase, NAD+, FAD, TPP, lipoic acid
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thiamine, riboflavin, pantothenic acid, niacin, lipoic acid
Frage 4
Frage
From what FOUR vitamins are the coenzymes of the PDH complex derived?
Antworten
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Vitamin B1, Vitamin B2, Vitamin B3, Vitamin B5
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Niacin, Riboflavin, Vitamin C, lipoic acid
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Vitamin B12, Vitamin B3, Vitamin B6, thiamine
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Thiamine, Vitamin B1, Riboflavin, Vitamin B2
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Thiamine, Riboflavin, Niacin, Vitamin B1
Frage 5
Frage
In the TCA, which enzymes catalyze forward reactions producing NADH?
Antworten
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Aconitase, Fumarase, Syccinyl CoA synthetase, Isocitrate dehydrogenase
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Isocitrate dehydrogenase, succinyl CoA synthetase, ketoglutarate dehydrogenase
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Isocitrate dehydrogenase, succinate dehydrogenase, ketoglutarate dehydrogenase
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Isocitrate dehydrogenase, malate dehydrogenase, ketoglutarate dehydrogenase
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Citrate synthase, malate dehydrogenase, ketoglutarate dehydrogenase
Frage 6
Frage
Carbon dioxide is released in two reactions of the TCA. Which two substrates are produced as a result of the decarboxylation reaction?
Antworten
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Isocitrate, L-Malate
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Succinyl CoA, Succinate
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alpha-ketoglutarate, Succinyl CoA
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Citrate, alpha-ketoglutarate
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Citrate, Fumarate
Frage 7
Frage
Which enzymes of the TCA are regulated?
Antworten
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ketoglutarate dehydrogenase, fumarase, aconitase, succinate dehydrogenase
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Malate dehydrogenase, citrate synthase, ketoglutarate dehydrogenase, isocitrate dehydrogenase
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Citrate dehydrogenase, isocitrate synthase, ketoglutarate dehydrogenase, succinate dehydrogenase
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citrate synthase, isocitrate dehydrogenase, ketoglutarate dehydrogenase, succinate dehydrogenase
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succinate thiokinase, citrate synthase, fumarase, aconitase
Frage 8
Frage
Which enzymes are regulated by Ca2+, ATP and NADH?
Antworten
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Citrate synthase, Isocitrate Dehydrogenase, ketoglutarate dehydrogenase, succinate dehydrogenase
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Citrate synthase, ketoglutarate dehydrogenase, succinate dehydrogenase
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Isocitrate Dehydrogenase, ketoglutarate dehydrogenase, succinate dehydrogenase
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Citrate synthase, Isocitrate Dehydrogenase, ketoglutarate dehydrogenase
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Citrate synthase, Isocitrate Dehydrogenase, succinate dehydrogenase
Frage 9
Frage
What enzymes in the TCA are regulated by other substrates?
Antworten
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Isocitrate Dehydrogenase, ketoglutarate dehydrogenase, succinate dehydrogenase
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Citrate synthase, Isocitrate Dehydrogenase, ketoglutarate dehydrogenase
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Citrate synthase, ketoglutarate dehydrogenase, succinate dehydrogenase
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Citrate synthase, Isocitrate Dehydrogenase, ketoglutarate dehydrogenase, succinate dehydrogenase
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Citrate synthase, Isocitrate Dehydrogenase, succinate dehydrogenase
Frage 10
Frage
What enzymes of the TCA are regulated by ADP?
Antworten
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Citrate synthase, Isocitrate Dehydrogenase, ketoglutarate dehydrogenase, succinate dehydrogenase
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Citrate synthase, Isocitrate Dehydrogenase, succinate dehydrogenase
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Citrate synthase, Isocitrate Dehydrogenase, ketoglutarate dehydrogenase
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Isocitrate Dehydrogenase, ketoglutarate dehydrogenase, succinate dehydrogenase
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Citrate synthase, ketoglutarate dehydrogenase, succinate dehydrogenase
Frage 11
Frage
List a cause, symptom and metabolic effect, respectively, of Werneke-Korsakoff syndrome.
Antworten
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thiamine deficiency, memory loss, and lactic acidosis
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riboflavin deficiency, wet beri-beri, increased ATP
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niacin deficiency, heart failure, increase NADH
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thiamine deficiency, cerebral hemorrhage, uncoupled ETC
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riboflavin deficiency, ataxia (lack of voluntary muscle control), decreased pyruvate
Frage 12
Frage
What is the mechanism of arsenic poisoning?
Antworten
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Inhibits ketoglurate dehydrogenase by binding to alpha-ketoglutarate.
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Inhibits dihydrolipoyl transacetylase by binding to lipoic acid.
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Inhibits PDH by binding to TPP.
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Inhibits pyruvate decarboxylase by binding to pyruvate.
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Inhibits dihydrolipoyl dehydrogenase by binding to FAD.
Frage 13
Frage
What enzyme is inhibited by fluorocitrate?
Antworten
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alpha-ketoglutarate dehydrogenase
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succinate dehydrogenase
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aconitase
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malonate dehydrogenase
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fumarase
Frage 14
Frage
What vitamin deficiencies result in malfunctions of the tricarboxylic acid cycle?
Antworten
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Vitamins B1, B2, B3, B5, B12
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niacin, riboflavin, thamine, pantothenate, lipoic acid
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NAD+, FAD, lipoic acid, coenzyme A, thiamine pyrophosphate
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niacin, riboflavin, nicotinamide, malonate, vitamin B12
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Niacin, vitamin B3, thiamine, vitamin B1, lipoic acid
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