Karteikarten
Glycolysis & PFK1/F1,6BPase
Karten in diesem Stapel (18)
- 1Function of GlycolysisProvides ATP from glucose, Acetyl CoA for FA synthesis, and carbon skeletons for aa sythesis
- 2In Muscle, glycolysis and gluconeogenesis areSimultaneous, as one feeds the other
- 3In liver, glycolysis and gluconeogenesis are...Incompatable- glucose produced must exit the liver to be used elsewhere
- 4Glycolysis RegulationControl glucose entry (GLUT2) or at committed steps
- 5PFK16- Phosphofructokinase 1 (the first committed enzyme) converts Fru-6-P to Fur-1,6-BP
- 6PFK1 StructureTetramer, with tense (active) and relaxed (inactive) form
- 7PFK1- ATP Binding2 sites- one allosteric, one catabolic (binds regardless of tense/relaxed state)
- 8PFK1- Allosteric ATPExcess ATP binds and encourages tense state (indicated energy dense cell)
- 9PFK1- F-6-P bindingOnly occurs in relaxed state
- 10PFK1- Allosteric AMPCompetes with ATP in low ATP concs, encouraging relaxed state
- 11PFK1- H+ ionsIndicate high levels of anaerobic respiration and so PFK1 is shut down for cellular protection
- 12Heart PFK1- H+ ionsEven in high H+ concs, heart PFK1 remains active as shutting it down is potentially fatal
- 13PFK1- CitrateInhibits PFK1 (Signals TCA cycle overload)
- 14PFK1- F-6-P SignalsGlucose entry/breakdown, acts as feedforward mechanism
- 15PFK1- F-2,6-BPPotent allosteric activator
- 16F-1,6-BPaseReverses action of PFK1 (though PFK1 works 10x faster)
- 17Active F-1,6-P LocationMuscles undergoing gluconeogenesis
- 18F-1,6-P - AMPAt low AMP, F-1,6-P activity exceeds that of PFK1 (this reverses as AMP levels rise)
Informationen
- Beschreibung
- Year 2 (Glycolysis) Karteikarten am Glycolysis & PFK1/F1,6BPase, erstellt von gina_evans0312 am 30/03/2014.
- Erstellt von
- gina_evans0312 · Mär 2014
- Aktualisiert
- 23 Nov 2016
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- 352
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