Quiz
CVS Physiology L3+4
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Questions in this quiz (28)
1Shortening of the muscle occurs by the [blank_start]sliding filament[blank_end] mechanism
- [blank_start]actin[blank_end] filaments slide along adjacent [blank_start]myosin[blank_end] filaments by cycling of cross-bridges with myosin
• The [blank_start]Z[blank_end] lines come closer together and the muscle cell shortens
• The cardiac muscle thus produces [blank_start]force[blank_end] or tension- Asliding filament
- Bactin
- Cmyosin
- DZ
- Eforce
2Fill in the blanks
- ATotal
- BActive
- CPassive
3This ability of cardiac muscle to increase its [blank_start]contractile[blank_end] force with a slight increase in its [blank_start]length[blank_end] underlies its ability to control [blank_start]stroke volume[blank_end] (the volume of blood ejected from the heart during a single beat)
- Acontractile
- Blength
- Cstroke volume
4 If the muscle is overstretched (ie, during dilation of the heart), its ability to produce an active tension is reduced
- ATrue
- BFalse
5Fill in the blanks
- Aejection
- Bfilling
- Cstroke volume
- Disovolumetric relaxation
- Eisovolumetric contraction
6What is this curve an example of?
- AStarling curve
7Label the graph with the following; increased, normal, decreased
- Aincreased
- Bincreased
- Cnormal
- Ddecreased
8Increased contractility means
- Ahigher stroke volume for the same end diastolic volume
- Blower stroke volume for the same end diastolic volume
- Chigher stroke volume for the higer end diastolic volume
- Dhigher stroke volume for the lower end diastolic volume
9A rise to a higher starling curve means decreased contractility
- ATrue
- BFalse
10 dP/dtmax is a good measure of
- Amyocardial contractility
- Bmyocardial reponse
- Cmyocardial dilation
- Dmyocardial pressure
11Label the following curves A, B and C
- Acontrol
- BB
- CC
12 Agents that cause an increase in contractility are said to have a positive [blank_start]inotropic[blank_end] effect
- Ainotropic
13Which of the following are examples of positive inotropic agents?
- Anoradrenaline
- Badrenaline
- Cdigoxin
- Dverapamil
14Positive inotropic agents have the general effect of increasing
- ACa^2+
- BK^+
- CCl^-
- DNa^+
15Which of the following are negative inotropic agents?
- Acalcium channel blockers
- Bbeta adrenergic blockers
- Chypoxia
- Depinephrine
16Fill in the blanks
- Aactin
- Btropomyosin
- Ctroponin complex
- Dmyosin body
- Emyosin head
- Fz line
17CICR stands for [blank_start]calcium induced calcium release[blank_end]
- Acalcium induced calcium release
18SERCA stands for [blank_start]sarcoplasmic endoplasmic reticulum[blank_end] calcium ATPase
- Asarcoplasmic endoplasmic reticulum
19Which of the following statements are true?
- AJunctional SR is studded with Ca2+ release channels
- BRYR is a giant protein with a terminal foot with a T-shaped tube in its centre through which Ca2+ ions are releases
- CThe density of RYR is low near L-type Ca channels
- DThe distance between the Ca channels and the RYR is very short (nm)
20Fill in the blanks
- A2
- B3
- C3
- Dphospholamban
- Ejunctional SR
- Fryanodine receptor
- Gtransverse tubule
- HCICR
- Iextracellular fluid
21What is SERCA regulated by?
- Aphospholamban
- Bryanodine
- CCICR
- Dnoradrenaline
22What happens at the end of contraction?
- ACa2+ influx ceases and the SR is no longer stimulated to release Ca2+
- Bthe intracellular concentration of Ca2+ must be rapidly reduced
- Cmost of the cytoplasmic Ca2+ is pumped back into the SR by SERCA
- Da small amount of calcium is pumped out of the cell by the cell membrane Ca pump
23What does sympathetic stimulation of the cardiac muscle produce?
- AIncrease in active tension
- BIncrease in the rate of active tension development
- CIncrease in the rate of tension relaxation
- DIncrease in passive tension
- EIncrease in the rate of passive relaxation
- Fdecrease in active tension
- Gdecrease in passive tension
24Fill in the blanks
- Abeta adrenergic stimulation
- Bcontrol
25Label the pink rectangles 1-12( step 2 is there twice). Label the blue ovals cardiac glycosides, catecholamine, troponin I, troponin C and phospolamban
- A1
- B2
- C2
- D3
- E4
- F5
- G6
- H7
- I8
- J9
- K10
- L11
- M12
- Ntroponin c
- Otroponin I
- Pphospholamban
- Qcatecholamine
- Rcardiac glycosides
26cAMP activates [blank_start]protein kinase A[blank_end]
- Aprotein kinase A
27Protein Kinase A [blank_start]phosphorylates[blank_end] the L-type calcium channel
- Aphosphorylates
28Which of the following are true?
- AIncreased intracellular Ca2+ concentration increases the force of contraction (positive inotropic effect)
- BProtein kinase A phosphorylates Phospholamban and Troponin I
- Cphosphorylation of troponin I leads to inhibition of binding of
calcium to troponin C and relaxation occurs - Dphosphorylation of phospholamban leads to reduced inhibition of SERCA which leads to increased uptake of calcium into the SR and relaxation occurs
- EPhospholamban phosphorylation promotes the rate of contraction
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- 1st year college CVS Physiology Quiz on CVS Physiology L3+4, created by Rachel O' Flynn on 24/02/2018.
- Author
- Rachel O' Flynn
- Language
- English
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