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MD15 and 20 Routes of delivery: Parenteral

Mer Scott 14 questions

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Questions in this quiz (14)

  1. 1Choose the incorrect statement about volumes that can be injected.
    1. AIntravenous: 1mL to 500mL
    2. BIntramuscular: 2 - 4 mL
    3. CSubcutaneous: <1mL
    4. DIntradermal: 0.1 - 1 mL
  2. 2Injection often selected when oral path is not feasible, eg if administering a
    drug that undergoes [blank_start]substantial first pass[blank_end] metabolism, or is [blank_start]poorly absorbed[blank_end] from the GI tract, or is [blank_start]unstable[blank_end] in the GI tract (eg. Insulin).
    1. Asubstantial first pass
    2. Bpoorly absorbed
    3. Cunstable
  3. 3Choose all advantages of parenteral injections.
    1. AProvides drug and nutritional options for patients unable to tolerate oral therapy
    2. BAdminister multiple drugs at once in an emergency
    3. COvercome absorption limitations of GI tract
    4. DQuick onset of action
    5. EProlonged duration of effect
    6. FLocalised delivery
    7. GDifficult/impossible drug removal/reversal
    8. HRequire that a skilled or trained person administer them
    9. IRisk of infection, emboli, or hypersensitivity reactions
    10. JHigher cost
  4. 4Parenteral formulation challenges: Drug solubility, Product stability (particularly [blank_start]biopharmaceuticals[blank_end]), Drug delivery ([blank_start]sustained/controlled[blank_end] after IM or SC), Sterility, Manufacturability
    Parenteral formulation components: Vehicle ([blank_start]aqueous vs. non-aqueous[blank_end]), Stabiliser, Buffering agents, Tonicity adjusters, Solubilizer, Wetting agents, Suspending agents, Emulsifying agents, Preservatives
    1. Abiopharmaceuticals
    2. Bsustained/controlled
    3. Caqueous vs. non-aqueous
  5. 5Choose the incorrect statement about why veins are used to inject into the circulation.
    1. ABlood loss in case of accidental venipuncture is less
    2. BVeins are thinner walled than arteries
    3. CVeins are low pressure systems compared to arteries
    4. DVeins are less superficial and easily accessible
  6. 6The IV route can give a rapid and predictable response, and can be stopped anytime.
    1. ATrue
    2. BFalse
  7. 7IV route: bolus vs infusion:
    1. Bolus: most [blank_start]rapid[blank_end] onset of drug action
    • Single rapid injection lasting [blank_start]1-2 min[blank_end]
    • Small volumes ([blank_start]<1 mL[blank_end])
    2. Infusion: slow injection of a substance into a vein
    • Over a period of [blank_start]several hours[blank_end] or more
    • Large volumes ([blank_start]> 500 mL[blank_end])
    • Sustained level of drug in the blood stream is required over a long period of time (eg. pain relief and many antibiotics)
    1. Arapid
    2. B1-2 min
    3. C<1 mL
    4. Dseveral hours
    5. E> 500 mL
  8. 8IV route complications:
    • [blank_start]Extravasation[blank_end]: Leakage of the injection from the vein into the surrounding tissue
    • [blank_start]Air embolism[blank_end]: Injection of air into a vessel
    • [blank_start]Thrombosis[blank_end]: Formation of a clot in a blood vessel
    • [blank_start]Haemolysis[blank_end]: Breakdown of red cells with the release of haemoglobin
    • [blank_start]Phlebitis[blank_end]: Inflammation of the vein wall due to irritation from the formulation
    • [blank_start]Pain[blank_end]
    1. AExtravasation
    2. BAir embolism
    3. CThrombosis
    4. DHaemolysis
    5. EPhlebitis
    6. FPain
  9. 9Choose the incorrect statement about the subcutaneous (SC) route
    1. ASuspensions, which are typically not viable for IV administration, may be given through the SC route
    2. BSC administration is limited by volume (<2 mL)
    3. CUseful for drug depot systems for rapid-release of drugs like insulin, narcotics, vitamin B12
  10. 10The more aqueous an IM injection/implant, the faster it releases.
    1. ATrue
    2. BFalse

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Description
PHCY211 (Medicines) Quiz on MD15 and 20 Routes of delivery: Parenteral, created by Mer Scott on 20/05/2018.
Author
Mer Scott
Language
English
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