Quiz
MD27 Clearance
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Questions in this quiz (5)
1Which of these elimination processes are first order? Select all.
- AElimination by passive diffusion eg filtration in the kidneys
- BElimination of drug that is limited by blood flow to the tissue
- CElimination of drug by metabolism via enzymes
2Choose the incorrect definition of clearance.
- AClearance is a constant that defines the relationship between plasma drug concentration and rate of elimination.
- BClearance is the volume of blood cleared of drug per unit time.
- CClearance is the product of perfusion and the ability of an organ to clear blood of drug.
- DClearance is the maintenance dose required to keep a steady state concentration of drug.
3At steady state, the dose rate [blank_start]equals[blank_end] the rate of elimination. The maintenance dose ([blank_start]mg/h[blank_end]) is that is equal to [blank_start]RE[blank_end] and able to maintain steady state, and it can be found by multiplying clearance ([blank_start]L/h[blank_end]) by the average steady state plasma concentration of a drug([blank_start]mg/L[blank_end]).
- Aequals
- Bmg/h
- CRE
- DL/h
- Emg/L
4Intrinsic clearance is the theoretical maximum rate at which a drug can be cleared if Q to an organ was infinite. It can be represented by the equation:
- ACLint = Vmax / Km
- BCLint = RE / Vmax
- CCLint = RE * Km
5AUC is the area under the [blank_start]concentration-time[blank_end] curve. It represents the [blank_start]total systemic exposure[blank_end] of the body to a dose of drug. If we estimate AUC by doing an intense [blank_start]PK[blank_end] study we can estimate [blank_start]CL[blank_end].
- Aconcentration-time
- Btotal systemic exposure
- CPK
- DCL
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- PHCY211 (Medicines) Quiz on MD27 Clearance, created by Mer Scott on 27/05/2018.
- Author
- Mer Scott
- Language
- English
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