Quiz
Antimicrobial Agents and Resistance
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Questions in this quiz (18)
1Penicillin is in which class of antibiotics?
- AB-lactams
- BGlycopeptides
- CMannopeptimycins
- DLantibiotics
2How have antibiotic developers overcome bacteria that resist B-lactams by preventing them from entering the cell?
- AProduce membrane pores
- BConjugate the B-lactam with a membrane transporter
- CConjugate the B-lactam with a siderophore
3In which decade was the first glycopeptide discovered?
- A1950's
- B1940's
- C1960's
- D1970's
4Which drug was easier for microbes to develop resistance towards?
- AB-lactams
- BVancomycin
5Are Mur enzyme inhibitors bacteriostatic or bactericidal?
- ABacteriocidal
- BBacteriostatic
6Reverse transcriptase has poor proofreading activity. What is a consequence of this?
- AMutations do not occur as often
- BThe viral genome is more likely to integrate permanently into the host genome
- CMutations arise quickly and could cause antiviral resistance
- DThe host cell genomic machinery is hijacked and loses proofreading ability
7A patient has unprotected sex with someone who is HIV-positive and soon tests positive for HIV. You prescribe AZT and Nelfinavir in combination therapy.
The viral load continues to increase rather than decrease. Based merely on this information, what do you think has occurred?- AThe HIV has mutated to be resistant to AZT and Nelfinavir in your patient
- BDrug-resistant HIV was transmitted to your patient
8A patient has unprotected sex with someone who is HIV-positive and soon tests positive for HIV. You prescribe AZT and Nelfinavir in combination therapy.
Your clinical microbiologist tests your patient’s HIV strain and find that it is currently not resistant to the drugs you have prescribed. Rather, your patient was not taking every dose of the antiviral cocktail. What should you, the doctor, do?- ATell the patient to begin taking the original drugs as prescribed
- BChange the prescription in case some viruses have gained mutations that make them resistant to the current drugs
- COrder another drug resistance test in a few weeks
- DBoth a and c
- EBoth b and c
9Doxycycline is an Tetracycline antibiotic used to treat a variety of bacterial infections, such as those causing acne, urinary tract infections, eye infections, and gum disease. However, it is imperative that children and pregnant or nursing mothers do not take this drug, as it can cause permanent yellowing/greying of teeth in babies and children.
The tooth discoloration is due to the fact that Tetracyclines can chelate (bind and sequester) the calcium ions needed for normal adult tooth development. Other than calcium, what do Tetracyclines bind to?- A50S ribosomal subunit
- B30S ribosomal subunit
- CDihydropteroate synthase
- DDNA helicase
- ERNA polymerase
10Doxycycline is an Tetracycline antibiotic used to treat a variety of bacterial infections, such as those causing acne, urinary tract infections, eye infections, and gum disease. However, it is imperative that children and pregnant or nursing mothers do not take this drug, as it can cause permanent yellowing/greying of teeth in babies and children.
A pregnant mother has a urinary tract infection. What antibiotic has the same mode of action as Doxycycline but wouldn’t cause the tooth discoloration in her child?- APenicillin
- BVancomycin
- CChloramphenicol
- DQuinolone
- EAminoglycoside
11Rabies virus has a negative-sense single-stranded RNA genome. It is a neurotropic virus that spreads through saliva.
There is a drug called Favipiravir that is being tested for use against Rabies. What do you think is the mode of action of Favipiravir?- AHalt DNA synthesis
- BHalt RNA synthesis
- CPrevent integration into host genome
- DInhibit reverse transcriptase
12You have a chronic athlete’s foot infection. Which antifungal cream would be the best choice?
- AItraconazole
- BClotrimazole
- CGriseofulvin
- DNystatin
- EAmphotericin B
13Trimethoprim-sulfamethoxaxole is used to treat Shigellosis. What is the mode of action of this Sulfonamide?
- AInhibit translation
- BInhibit nucleotide synthesis
- CInhibit cell wall biosynthesis
- DInhibit bacterial adherence to host cell
14[blank_start]Selective toxicity[blank_end] refers to the ability of an antimicrobial drug to harm the target microbe without harming the host?
- ASelective toxicity
15In the Kirby-Bauer disk diffusion test, the [blank_start]diameter[blank_end] of the zone of inhibition is measured and used for interpretation.
- Adiameter
16A scientist discovers that a soil bacterium she has been studying produces an antimicrobial that kills gram-negative bacteria. She isolates and purifies the antimicrobial compound, then chemically converts a chemical side chain to a hydroxyl group. When she tests the antimicrobial properties of this new version, she finds that this antimicrobial drug can now also kill gram-positive bacteria. The new antimicrobial drug with broad-spectrum activity is considered to be [blank_start]semi-synthetic[blank_end].
- Asemi-synthetic
17Which clinical situation would be appropriate for treatment with a narrow-spectrum antimicrobial drug?
- Atreatment of a polymicrobic mixed infection in the intestine
- Bprophylaxis against infection after a surgical procedure
- Ctreatment of strep throat caused by culture identified Streptococcus pyogenes
- Dempiric therapy of pneumonia while waiting for culture results
18Narrow-spectrum antimicrobials are commonly used for prophylaxis following surgery.
- ATrue
- BFalse
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- W12Th
- Author
- Amanda A
- Language
- English
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