Quiz
Pharmacology IV
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Questions in this quiz (16)
1A pharmacologic agonist is a chemical substance that
- Aa. Binds to a specific receptor and produces a response
- Bb. Elicits a pharmacologic response without binding to a receptor
- Cc. Possesses the property of affinity but not of intrinsic activity
- Dd. Exhibits no activity except to oppose the effect of an antagonist
2When comparing drugs with respect to intensity of response, the drug that produces the greatest maximum effect is the one with the highest
- Aa. Affinity
- Bb. Potency
- Cc. Efficacy
- Dd. Therapeutic index
3If drug has a greater efficacy than drug B, then drug A
- Aa. Is more toxic than drug B
- Bb. Has a greater affinity for the receptor than drug B
- Cc. Has a greater margin of safety than drug B
- Dd. Is capable of producing a greater maximum effect than drug B
4A drug with a high LD50 and a low ED50 has a
- Aa. High therapeutic index and is, therefore, very dangerous
- Bb. High therapeutic index and is, therefore, relatively safe
- Cc. Low therapeutic index and is, therefore, very dangerous
- Dd. Low therapeutic index and is, therefore, relatively safe
5The ratio of the median lethal dose (LD50) to the median effective dose (ED50) is the
- Aa. Morbidity index
- Bb. Mortality index
- Cc. Anesthetic ratio
- Dd. Therapeutic index
6The therapeutic index of a drug is the ratio of
- Aa. The effective dose to the toxic dose
- Bb. Half the toxic dose to half the effective dose
- Cc. The maximum tolerated dose to the minimum effective dose
- Dd. The lethal dose for 50% of animals to the effective dose for 50% of animals
7The phenomenon in which two drugs produce opposite effects on a physiologic system but do not act at the same receptor site is
- Aa. Potentiation
- Bb. Chemical Antagonism
- Cc. Competitive antagonism
- Dd. Physiologic antagonism
8Epinephrine antagonizes the effects of histamine by
- Aa. Preventing the release of histamine
- Bb. Acting on the central nervous system
- Cc. Producing physiologic actions opposite to that of histamine
- Dd. Competitively blocking histamine at the cellular receptor site
9Interaction between nitroglycerin and epinephrine is what type of antagonism?
- Aa. Allosteric
- Bb. Physiologic
- Cc. Biochemical
- Dd. Competitive
- Ee. Pharmacologic
10When the combined action of two drugs is greater than the sum of their individual actions, this is
- Aa. Induction
- Bb. Synergism
- Cc. Idiosyncrasy
- Dd. Hypersensitivity
- Ee. Cumulative action
11Which of the following responses is least predictable in occurrence?
- Aa. Toxicity
- Bb. Side-effects
- Cc. Idiosyncrasy
- Dd. Tachyphylaxis
- Ee. Therapeutic effects
12Idiosyncrasies to drugs are related to
- Aa. Species
- Bb. Genetic factors
- Cc. Age of the patient
- Dd. All of the above
13Two drugs, A and B, have the same mechanism of action. Drug A in a dose of 5 mg. produces the same magnitude of response as drug B in a dose of 500 mg. Which of the following statements is correct?
- Aa. Drug A is less toxic
- Bb. Drug A is more efficacious
- Cc. Drug A is 100 times as potent
- Dd. Drug A has a shorter duration of action
- Ee. Drug A is a better drug to use when a maximal response is desired
14According to the theory that agonists and antagonists occupy the same receptor site, an effective antagonist should exhibit
- Aa. High intrinsic activity and high affinity
- Bb. Low intrinsic activity and low affinity
- Cc. High intrinsic activity and low affinity
- Dd. No intrinsic activity and high affinity
15All of the following statements are true regarding the occupation theory of drug-receptor interaction EXCEPT:
- Aa. The affinity of a drug is dependent on its intrinsic activity
- Bb. The maximum effect of a drug occurs when all receptors are occupied
- Cc. An antagonist has affinity for the receptor but not intrinsic activity
- Dd. The magnitude of the effect of a drug is proportional to the number of receptors occupied
- Ee. It follows the law of mass action
16The occupational theory of drug-receptor interaction states that
a. The magnitude of the drug response is proportional to the number of receptors occupied
b. A partial agonist has intrinsic activity but no affinity for the receptor site
c. An antagonist drug has affinity but no intrinsic activity
d. The rate at which the drug-receptor complex associates and dissociates determines drug efficacy
e. The degree of drug action is dependent on the law of mass action- Aa) (a), (b) and (c)
- Bb) (a), (c) and (e)
- Cc) (b), (c) and (d)
- Dd) (b) and (e)
- Ee) (c), (d) and (e)
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- Praxis Tests: Pharmacology Quiz on Pharmacology IV, created by ACAPUN INSTITUTE on 08/11/2021.
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- ACAPUN INSTITUTE
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- Español
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