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LESSON 17: PYRUVATE AND CAC

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Questions in this quiz (9)

  1. 1Which of these is not true?
    1. AThe outer mitochondrial membrane is crossed by facilitated diffusion by cotransport with a proton
    2. BPyruvate is going to be transformed into Acetyl coenzyme A and one molecule of CO2
    3. CThe oxidative decarboxylation of pyruvate is catalyzed by pyruvate dehydrogenase complex
    4. DPyruvate dehydrogenase complex is constituted by 3 different kind of enzymes and 5 different coenzymes
    5. EThe pyruvate that is formed in glycolysis will be transferred into mitochondrial matrix
  2. 2About the enzymes E1, E2 and E3, which of these is true?
    1. A1.) Enzyme 1 contains TPP as coenzyme and it is involved in the oxidative decarboxylation of pyruvate
    2. B2.) Enzyme 2 contains Lipoamide that is involved in the transfer of one hydroxyethyl group to CoA
    3. C3.) Enzyme 3 contains as coenzyme FAD and it is involved in the regeneration of oxidative form of lipoamide
    4. D1.) and 3.) are both true
    5. EAll are true
  3. 3Pyruvate is going to suffer a oxidative dicarboxylation that is catalyzed by Ez 1, and in this reaction, one molecule of CO2 is going to be released and one hydroxyethyl group is going to be linked to the coenzyme TTP of E1.
    1. ATrue
    2. BFalse
  4. 4In the regulation of PDH, when PDH will be active?
    1. APDH will be active when is not phosphorylated and when levels of NADH and Acetyl CoA are low.
    2. BPDH will be active when is phosphorylated and when levels of NADH and Acetyl CoA are low.
    3. CPDH will be active when is not phosphorylated and when levels of NADH and Acetyl CoA are high.
    4. DPDH will be active when is phosphorylated and when levels of NADH and Acetyl CoA are high.
    5. EAny of these
  5. 5Which of these about the Citric Acid Cycle is not true?
    1. ACAC is cycle and it takes place in mitochondria
    2. BCAC is one pathway that is used in the metabolism of carbohydrates, amino acids and lipids
    3. CIt is responsible of the production of 1 third of the total energy (ATP)
    4. DIt is an amphipathic pathway
    5. EThere are 3 points of regulation in the cycle
  6. 6The three reaction regulated in CAC are...?
    1. A- Oxaloacetate condense with Acetyl CoA forming Citrate
      - Alfa-ketoglutarate suffer one oxidative decarboxylation forming Succinyl CoA
      - Malate is oxydased and one molecule of NADH is formed
    2. B- Citrate is transformed to its isomer that is called Isocitrate
      - Isocitrate suffer one oxidative decarboxylation and it is transformed into alfa-ketoglutarate
      - Fumarate is transformed into malate
    3. C- Oxaloacetate condense with Acetyl CoA forming Citrate
      - Fumarate is transformed into malate
      - Malate is oxydased and one molecule of NADH is formed
    4. D- Citrate is transformed to its isomer that is called Isocitrate
      - Isocitrate suffer one oxidative decarboxylation and it is transformed into alfa-ketoglutarate
      - Succinate is oxydased to fumarate
    5. E- Oxaloacetate condense with Acetyl CoA forming Citrate
      - Isocitrate suffer one oxidative decarboxylation and it is transformed into alfa-ketoglutarate
      - Alfa-ketoglutarate suffer one oxidative decarboxylation forming Succinyl CoA
  7. 7For each molecule of AcetylCoA we finally obtain...?
    1. A3NADH, 1 FADH2, 1 GTP, 2CO2: 12 ATP
    2. B2NADH, 2 FADH2, 1 GTP, 2CO2: 12 ATP
    3. C3NADH, 2 FADH2, 1 GTP, 2CO2: 12 ATP
    4. D3NADH, 2 FADH2, 2 GTP, 2CO2: 14 ATP
    5. E3NADH, 1 FADH2, 1 GTP, 1CO2: 12 ATP
  8. 8Which are the enzymes that are submitted to CAC regulation?
    1. ACitrate synthase, malate dehydrogenase and alfa-ketoglutarate dehydrogenase complex
    2. BCitrate synthase, isocitrate dehydrogenase and alfa-ketoglutarate dehydrogenase complex
    3. CCitrate synthase, succinate dehydrogenase and alfa-ketoglutarate dehydrogenase complex
    4. DCitrate synthase and alfa-ketoglutarate dehydrogenase complex
    5. EAny of these is totally true
  9. 9The inhibitors of the enzymes acting in CAC regulation rare ATP and NADH and the activator is ADP
    1. ATrue
    2. BFalse

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Oxidative decarboxylation of pyruvate and Citric Acid Cycle test
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