13992232
Description
Flashcards by Jennifer Huber, updated more than 1 year ago
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Created by Jennifer Huber
almost 6 years ago
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| Question | Answer |
| Blood products that don't carry a risk of HIV or hepatitis | Albumin and serum globulins |
| What is donated blood screened for? | HIV, HepB, HepC, HTLV, syphilis, West Nile virus |
| Who do you use CMV negative blood on? | use in low-birth weight infants BM transplant patients Other transplant patients |
| Universal Blood Donor, Blood type | Type O, contains no antigens |
| What type of blood should females of childbearing age receive if need blood products? | Rh-negative blood |
| Bohr Effect on Stored Blood | low in 2,3-DPG causing a left shift increased affinity for oxygen |
| Type and Crossmatch | determines ABO compatibility |
| Type and Screen | determines ABO compatibility and looks for preformed Ab's to minor antigens |
| How much does 1U of pRBC raise Hb and Hct by? | 1UpRBC increases Hb by 1 and Hct by 3-5 |
| One 6pack of Platelets should increase platelet count by how much? | 50,000 |
| Acute Hemolysis its cause, type of hypersensitivity, symptoms | From ABO incompatibility Type II HS Back pain, chills, tachycardia,fever, hemoglobinuria |
| Effects of acute hemolysis on Haptoglobin, free Hb, unconjugated bilirubin | Haptoglobin <50mg/dL Free Hb >5g/dL Increase in unconjugated bilirubin |
| Treatment for Acute Hemolysis | fluids, diuretics, HCO3, pressors |
| What is delayed hemolysis and what is its treatment? | mild jaundice antibody mediated against minor antigens from donor Tx: observe if stable |
| What is non-immune hemolysis? How to treat? | from squeezed blood tx: fluids and diuretics |
| MC transfusion reaction | Febrile nonhemolytic transfusion reaction |
| Cause of febrile nonhemolytic transfusion reaction | recipient antibody reaction against donor WBC (cytokine release) |
| Treatment for febrile nonhemolytic transfusion reaction | d/c transfusion + antipyretics (not aspirin) use WBC filters for subsequent transfusions |
| Cause of urticaria during blood transfusions | nonhemolytic recipient antibodies against donor plasma proteins or IgA in an IgA deficient pt |
| Treatment of Urticaria during blood transfusions | benadryl, supportive treatment |
| Anaphylaxis during blood transfusions symptoms and why it occurs | bronchospasm, HoTN, angioedema, urticaria Recipient Abs against donor IgA in IgA deficient patient |
| Treatment for anaphylaxis | Epinephrine, fluids, pressors, steroids, histamine blockers like Benadryl |
| Transfusion-related acute lung injury (TRALI) | caused by donor antibodies to recipient's WBCs, clot in pulm capillaries Leads to ARDS in <6hrs MCC of death from transfusions |
| How does the cold affect blood transfusions? | coagulopathy due to slowing of enzyme reactions |
| How Hypocalcemia affect blood transfusions | can cause poor clotting as it is required for clotting cascade Seen with massive transfusions |
| How Citrate affects blood products | binds calcium after transfusion and causes hypocalcemia |
| Most common bacterial contaminate in blood transfusions | GNRs, usually E. coli |
| Most common blood product source of contamination | Platelets, because they are not refrigerated |
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