592925
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
almost 12 years ago
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| Question | Answer |
| Isotypes | Ig classes based on 5 H chain variations |
| L Chain Variations | Kappa or Lambda (not both) |
| Functional Changes In Isotypes | Different Isotypes have different functions |
| Different Isotypes | Have different structures and bind to different receptors |
| IgG (Most Common)- Function | Fixes compliment and promotes opsonisation |
| IgG- Placenta Crossing | Only Ig to do so |
| IgA Secretion | Done by B cells (most common in external secretions) |
| Serum IgA | Monomer |
| Secreted IgA | Dimer |
| IgA Secretion Requirements | IgA, and IgAR, a receptor found in the inner lining of epithelial cells |
| IgA Transcytosis | The IgA and IgAR are passed through the epithelial cell |
| IgA Exocytosis | The IgA and the IgAR remain bound (though it's partially degraded) |
| IgE | Cause activation of allergic response- recognised by Mast cells |
| Role of IgM | Increases antigen avidity & is most effective at fixing compliemnt |
| IgM Structure | Forms a pentamer held by disulphide bonds |
| IgM & IgD | Form the BCR |
| Avidity | Overall strength of Ig-Ag interaction |
| B Cell Recognition | Can recognise any type of antigen (lipid/peptide/glycoprotein) |
| T-Cell Recognition | Only recognise small, processed peptides |
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