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NE1 Intro and CNS revision
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1Message from brain or spinal cord to the muscles, organs is [blank_start]efferent[blank_end].
Message from receptors to the brain or spinal cord is [blank_start]afferent[blank_end].
Interneuron relays between [blank_start]sensory and motor[blank_end] neurons.
Information flows from one neuron to another across a synapse, changing [blank_start]action potential[blank_end] to [blank_start]neurotransmitter[blank_end] and back.
• Target cell MORE likely to fire = [blank_start]excitatory[blank_end]
• Target cell LESS likely to fire = [blank_start]inhibitory[blank_end]
[blank_start]INTEGRATION[blank_end] = ‘decides’ whether to fire AP
[blank_start]Spatial[blank_end] summation: different locations at same time
[blank_start]Temporal[blank_end] summation: same place, slightly different times- Aefferent
- Bafferent
- Csensory and motor
- Daction potential
- Eneurotransmitter
- Fexcitatory
- Ginhibitory
- HIntegration
- ISpatial
- JTemporal
2Neurotransmitters:
Conventional -
1. Small molecules
• Amino acids: [blank_start]Glutamate, glycine, GABA[blank_end]
• Biogenic amines: [blank_start]Dopamine, adrenaline,[blank_end] noradrenaline, serotonin, histamine
• Purines: [blank_start]ATP, adenosine[blank_end]
2. [blank_start]Acetylcholine[blank_end]
3. Neuropeptides: [blank_start]Enkephalin, endorphins, substance P,[blank_end] Neuropeptide Y
Non conventional -
1. [blank_start]Endocannabinoids[blank_end]
2. Gasotransmitters: [blank_start]carbon monoxide, nitric oxide[blank_end]- AGlutamate, glycine, GABA
- BDopamine, adrenaline,
- CATP, adenosine
- DAcetylcholine
- EEnkephalin, endorphins, substance P,
- Fcarbon monoxide, nitric oxide
- GEndocannabinoids
3Choose the correct statement.
- AGlutamate is the main excitatory NT
- BGABA is the main inhibitory NT in the spinal cord
- CGlycine is the main inhibitory NT in the brain
4Aspects of neurotransmission (synthesis, storage, release, reuptake) are affected by many drugs. General drug effects:
1. Storage
Facilitates storage (e.g., by acting as a precursor) – [blank_start]agonist[blank_end]
Inhibits storage (e.g.by inhibiting synthesis or by blocking storage into vesicles) – [blank_start]antagonist[blank_end]
2. Release
Increases release – [blank_start]agonist[blank_end]
Prevents release – [blank_start]antagonist[blank_end]
3. Reuptake/breakdown
Facilitates reuptake/breakdown - [blank_start]antagonist[blank_end]
Inhibits reuptake/breakdown - [blank_start]agonist[blank_end]- Aagonist
- Bantagonist
- Cantagonist
- Dagonist
- Eagonist
- Fantagonist
- Gantagonist
- Hagonist
- Iantagonist
- Jagonist
- Kagonist
- Lantagonist
5Drugs affecting dopaminergic neurons:
Synthesis - [blank_start]L-DOPA[blank_end] facilitates synthesis of DA by acting as a precursor - agonist
Storage - [blank_start]Reserpine[blank_end] blocks DA uptake into vesicles – antagonist
Action - [blank_start]Selegeline[blank_end] prolongs action of DA by blocking degradation (MAO-B inhibitor) - agonist
Release - Amphetamine increases release of DA - agonist
Reuptake - [blank_start]Cocaine[blank_end] and amphetamine blocks DA reuptake - agonist
Drugs affecting serotonergic(5-HT) neurons:
Synthesis - α-Methyltyrosine inhibits synthesis of 5-HT - antagonist
Release - [blank_start]Fenfluramine[blank_end] facilitates the release of 5-HT - agonist
Reuptake - [blank_start]Fluoxetine[blank_end] blocks reuptake of 5-HT- agonist- AL-DOPA
- BReserpine
- CSelegeline
- DCocaine
- EFluoxetine
- FFenfluramine
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- User has deleted their subject information Quiz on NE1 Intro and CNS revision, created by Deleted user on 11/10/2019.
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- Created on 11 Oct 2019 · updated on 11 Oct 2019
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