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Questions in this quiz (17)
1What features define general anaesthesia in clinical applications?
- AA Loss of consciousness, analgesia, muscle relaxation & amnesia
- BHyperesthesia, analgesia & loss of consciousness
- CDepression, cardiovascular & respiratory depression, loss of consciousness
- DNervous system excitation, increased heart and respiratory rate
2It is possible but usually impractical to achieve all components of anaesthesia with a single drug?
- ATrue
- BFalse
3What factors will determine potency, rate of induction and recovery from an inhalation anaesthetic?
- AConc. of the anaesthetic in inspired air
- BAlveolar ventilation & respiration rate
- CSolubility of anaesthetic in blood
- DCardiac output & lung perfusion
- ELipophilicity of the anaesthetic
- FAll answers are correct
4In a dog, the minimum alveolar concentration of an inhalation anaesthetic will be increased by the concomitant use of central nervous system stimulants and hyperthermia.
- ATrue
- BFalse
5What drugs represent the most commonly used inhalation anaesthetics in veterinary medicine?
- AChloroform, Ether and Thiopental
- BIsoflurane, Sevoflurane & Methoxyflurane
- CAlfaxalone, Etomidate & Ketamine
- DPropofol, Ketamine & Xylazine
6What pharmacological effect is only attributed to nitrous oxide due to its inhibitory effect on the NMDA glutamate receptor
- ADepression of cardiovascular & respiration function
- BDepression of CNS, cardiovascular & respiratory function
- CHistamine release & anaesthesia-induced allergies
- DIntrinsic analgesic properties
7Of all the general anaesthetics, intravenously injected drugs are mostly used as induction agents while inhalation anaesthetics can be used for both induction & maintenance
- ATrue
- BFalse
8We won’t be discussing toxicological aspects of individual anaesthetics in detail BUT, does repeated administration/dosing with injectable anaesthetics lead to linear, saturation zero order kinetics?
- ATrue
- BFalse
9Procaine is often incorporated in injectable penicillin to prolong the half-life of the antibiotic & avoid the pain associated with intramuscular injection.
Why is the use of procaine or other LAs banned in racing horses?- AMasks pain & causes CNS depression
- BIncreases pain & causes CNS depression
- CMasks pain & causes CNS stimulation
10Which of the following processes is involved in the mechanism of action of local anaesthetics?
- ABlocking voltage gated sodium channels
- BBlocking voltage gated potassium channels
- CBlocking calcium channels
- Dboth Blocking voltage gated sodium channels
and Blocking voltage gated potassium channels - Eall answers are correct
11Outline the likely effect of lowering tissue pH (e.g. due to inflammation & necrosis) on tissue penetration by amide-based local anaesthetics such as lidocaine
- ALow pH increases tissue penetration of weakly basic drugs (amides)
- BLow pH decreases tissue penetration of weakly basic drugs (amides)
- CThere is no conceivable effect
12Which of the following statements is true about the “use-dependence” characteristic of local anaesthetics?
- AWhich of the following statements is true about the “use-dependence” characteristic of local anaesthetics?
- BIt is due to a higher affinity for activated than resting channels
- CIt is useful for the antiarrhythmogenic property of local anaesthetics
- DIt is useful for the anticonvulsive property of local anaesthetics
- Eall answers are correct
13Which of the following nerves is most likely to be affected by local anaesthetics first?
- AA-alpha fibres (13-20 µm diameter)
- BA-beta fibres (6-12 µm diameter)
- CA-delta fibres (1-5 µm diameter)
- DGamma motor neurons
14What properties are likely to affect the potency and duration of action of a local anaesthetic?
- ApH of the drug vehicle and the tissue into which it is infused
- BThe lipid solubility of a particular local anaesthetic
- CProtein binding and rate of diffusion of the local anaesthetic
- DLocal vasodilator activity in the tissue
- Eall answers are correct
15Which of the following commonly used tranquilisers has a reasonable duration of action (2-6 hours), works by blocking dopamine receptors but may also decrease systematic vascular resistance and blood pressure by blocking alpha adrenergic receptors?
- AAcepromazine
- BXylazine
- CDiazepam
- DMeditomidine
16Your anaesthesia patient is exhibiting a marked drop in blood pressure but not heart rate due to acepromazine that was administered as a pre-anaesthetic drug. Which of the following interventions or therapeutic options is likely to worsen the hypotensive effects?
- AWarming the animal to correct hypothermia
- BAdministering Dopamine
- CAdministering Adrenaline
- DAdministering Phenylephrine
17You have a horse that has been pre-medicated with a commercial combination of meditomidine (alpha-2 agonist) and ketamine but it is now presenting with severe adverse effects characterised by a reflex bradycardia, hypotension and a marked drop in cardiac output. What drug combination would you administer to reverse these effects?
- AThiopental and Isoflurane
- BMorphine and Diazepam
- CButorphanol and Naloxone
- DAtropine and Atipamezole
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- TV3002- pharmacology (Revision) Quiz on Revision MCQ, created by Kayleigh Van on 07/11/2017.
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- Kayleigh Van
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- English
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