Quiz
Myeloproliferative Disorders
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Questions in this quiz (20)
1Philadelphia Chromosome is most associated with which form of Leukaemia?
[blank_start]Chronic Myeloid Leukaemia[blank_end]- AChronic Myeloid Leukaemia
2Chronic Myeloid Leukaemia is fatal without stem cell/bone marrow transplantation in the chronic phase
- ATrue
- BFalse
3Which of the following conditions can in some cases present as Gout?
- AAcute Myeloid Leukaemia
- BAcute Lymphoblastic Leukaemia
- CChronic Lymphoblastic Leukaemia
- DChronic Myeloid Leukaemia
4Which of the following would describe findings fitting with a diagnosis of Chronic Myeloid Leukaemia?
- ANeutrophilia, Eosinophilia, Basophilia, Thrombocytosis
- BNeutropenia, Eosinopenia, Basopenia, Thrombocytopenia
5[blank_start]Chronic Myeloid Leukaemia[blank_end] - Causes a drastic rise in erythrocytes, platelets, neutrophils, etc
[blank_start]Acute Myeloid Leukaemia[blank_end] - Causes a drastic fall in erythrocytes, platelets, neutrophils, etc- AAcute Myeloid Leukaemia
- BChronic Myeloid Leukaemia
6Philadelphia Chromosome causes expression of a new gene encoding a protein kinase. Which of the following protein kinase inhibitors can be used to successfully treat Chronic Myeloid Leukaemia?
- ATyrosine Kinase Inhibitors
- BProtein Kinase A Inhibitors
- CProtein Kinase G Inhibitors
- DProtein Kinase C Inhibitors
- ETyramine Kinase Inhibitors
7The main tyrosine kinase inhibitor used to treat chronic myeloid leukaemia is called [blank_start]Imatinib[blank_end]
- AImatinib
8A patient presents to their GP complaining of headache, fatigue and an intense itching which only ever occurs whilst in the bath or shower. Their blood results show high haemoglobin levels accompanied by erythrocytosis (increase in circulating RBCs). What is your working diagnosis?
[blank_start]Polycythaemia Rubra Vera[blank_end]- APolycythaemia Rubra Vera
9The presence of a JAK2 mutation in a patient would immediately lead you to thinking of which Myeloproliferative disorder?
[blank_start]Polycythaemia Rubra Vera[blank_end]- APolycythaemia Rubra Vera
10The main treatment for polycythaemia rubra vera is regular [blank_start]venesection[blank_end]
- Avenesection
11The treatment for Polycythaemia Rubra Vera is venesection until the haematocrit falls below [blank_start]0.45[blank_end]
- A0.45
- B0.55
- C0.65
- D0.35
12An uncontrolled production of abnormal platelets is known as Essential [blank_start]Thrombocythaemia[blank_end]
- AThrombocythaemia
13Essential Thrombocythaemia causes excessive bleeding problems
- ATrue
- BFalse
14Teardrop-shaped Red Blood Cells in the peripheral blood is characteristic of which Myeloproliferative Disorder?
- AIdiopathic Myelofibrosis
- BEssential Thrombocythaemia
- CPolycythaemia Rubra Vera
15Idiopathic [blank_start]Myelofibrosis[blank_end] is a condition in which the proliferation of an abnormal clone of a hematopoietic stem cell results in fibrosis, or the replacement of bone marrow with scar tissue
- AMyelofibrosis
16Myelofibrosis typically results in hepatomegaly
- ATrue
- BFalse
17What is the first line treatment for essential thrombocythaemia?
- AInterferon Gamma
- BInterferon Beta
- CHydroxycarbamide
- DAspirin
- EClopidogrel
18Which of the following can be used as a secondary therapy for Essential Thrombocythaemia?
- AInterferon Gamma
- BInterferon Alpha
- CInterferon Beta
19Chronic Haemolysis predisposes an individual to gallstones
- ATrue
- BFalse
20Chronic haemolysis predisposes to gallstones as there are raised levels of [blank_start]bilirubin[blank_end] in the blood
- Abilirubin
Information
- Description
- Chronic Myeloid Leukaemia, Polycythaemia Rubra Vera, Essential Thrombocythaemia and Idiopathic Myelofibrosis
- Author
- Matthew Coulson
- Language
- English
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- 1,079
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