JA Turning Point

1. 1All of the following statements are True, EXCEPT?

   1. AProteins poorly penetrate the BBB
   2. BThe primary structure of a protein is the sequence of amino acids.
      
   3. CAll proteins are made up of one or more polypeptide chains.
      
   4. DProteins are considered hydrophobic.
      
2. 2Which of the following amino acid(s) should be most soluble in water?

   1. ASer
   2. BMet
   3. CVal
3. 3What is the amino acid sequence of the peptide below?

   

   1. ASer-Trp-Thr-Asn-Val-Glu
      
   2. BThr-His-Cys-Asn-Val-Gln
      
   3. CTrp-Phe-Asn-Ala-Ser-As
   4. DCys-Tyr-Asn-Ser-Leu-Asn
      
4. 4The amino acids are classified as:

   

   1. ACharged amino acid
   2. Bpolar amino acid
   3. CNon-polar amino acid
5. 5Using the CORN rule, would the following amino acid be active in a protein?

   

   1. ANo, because it is L form
   2. BYes, because it is L form
   3. CNo, because it is D form
   4. DYes, because it is D form
6. 6Tyr is an essential amino acid that is the precursor for the non-essential amino acid Phe

   1. ATrue
   2. BFalse
7. 7The pka values for Glu α-carboxylic acid and α-amino groups are 3.20 and 9.67, respectively and the pka of the side chain is 4.25. Which is the correct pI for Glu?

   1. A12.8
   2. B9.13
   3. C3.72
   4. D6.96
8. 8The meaning of isoelectric point is

   1. AThe pH at which the amino acid is positively charge
   2. BThe pH at which the amino acid is soluble
   3. CThe pH at which the amino acid is negatively charged
   4. DThe pH at which the amino acid carries no net charge
9. 9Hydrolysis of Leu-enkephalin by the gastrointestinal endopeptidase elastase would cleave which amino acid side chains?

   1. APhe and Leu
   2. BGly and Gly
   3. CTyr and Phe
   4. DGly and Leu
10. 10Serotonin is a neurotransmitter that regulates mood. Which amino acid is the precursor to serotonin?

    

    1. AA
    2. BB
    3. CC
    4. DD

11. 11What is the amino acid sequence of the pentapeptide below?

    

    1. AThr-Lys-Try-Ser-Gln-Asp-Arg
       
    2. BTrp-Asn-His-Thr-Leu-Glu-Phe
       
    3. CMet-Arg-Pro-Val-Lys-Asn-Cys
       
    4. DCys-Arg-His-Val-Lys-Asp-Met
       
12. 12The two major reasons why peptide drugs like insulin are administered via subcutaneous injection and not orally are

    1. ABecause peptide drugs have low lipid solubility and are stable against enzymatic degradation.
       
    2. BBecause peptides are highly lipid soluble and are instable against enzymatic degradation.
       
    3. CBecause peptide drugs have low lipid solubility and are instable against enzymatic degradation.
       
    4. DBecause peptides drugs are highly lipid soluble and are stable to enzymatic degradation.
       
13. 13At high pH (11.0), Leu is deprotonated at both the amine and carboxyl group. At this pH the molecule carries a zero net charge.

    1. ATrue
    2. BFalse
14. 14Which amino acid is the precursor for catecholamines (i.e. DA, NE, Epi)?

    

    1. AA
    2. BB
    3. CC
    4. DD
15. 15There are 4 structural levels in a protein; the primary level is:

    1. AThe multiple subunits and domains
       
    2. BThe 3-D native structure
       
    3. CThe alpha helices and beta sheets
       
    4. DThe amino acid sequence
       
16. 16Intramolecular hydrogen bonding is when there is a hydrogen bond connecting electronegative atoms within the same molecule.

    1. ATrue
    2. BFalse
17. 17The secondary structures of a protein are formed by

    1. AHydrogen bonding between the groups of the polypeptide backbone.
       
    2. BHydrogen bonding between the hydrophobic side chains.
       
    3. CHydrogen bonding between the charged side chains.
       
18. 18Non-covalent forces that are involved in the folding and stabilization of a protein structure include all of the following EXCEPT:

    1. AIonic Interactions
    2. BVan der Waals
    3. CHydrogen bonding
    4. DDisulfide Bonds
19. 19When a protein (alone) folds into a globular protein:

    1. AThere is an increase in the non-covalent force and increase in enthalpy
    2. BThere is an increase in the non-covalent force and decrease in enthalpy
    3. CThere is an decrease in the non-covalent force and increase in enthalpy
    4. DThere is an decrease in the non-covalent force and decrease in enthalpy
20. 20In an aqueous environment the entropy is increased when the protein goes from:

    1. Aunfolded to folded
    2. Bfolded to unfolded

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Quiz on JA Turning Point, created by AmberRose on 27/08/2015.

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AmberRose

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