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Unit 4 Endocrine MCQ test
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Questions in this quiz (52)
1Cortisol inhibition of corticotrophin releasing hormone (CRH) secretion is an example of?
- Aparacine action
- Bendocrine action
- Cautocrine action
- Dneurocrine action
2The anterior pituitary receives hypothalamic input via:
- Athe hypothalamo-physio-portal blood system
- Bnervous innervation
- Cparacrine inhibition by the pars nervosa
- Dneurocrine stimulation
3Production of the thyroid hormones, thyroxine (T4) and triiodothyronine (T3) occurs within:
- Athyrotroph cells
- BC cells
- Cthyroglobulin
- Dmitochondria
- Ethyrotrophin releasing hormone (TRH) neurons
4Which of the following symptoms might be observed in a patient with an activating mutation in the adrenocorticotrophin hormone (ACTH) receptor?:
- Adecreased prolactin secretion
- Belevated cortisol production
- Cabsent Synacthen response
- DBothelevated cortisol production and absent Synacthen response
- EBoth decreased prolactin secretion and absent Synacthen response
5Gonadectomy (removal of either testes or ovaries) would result in:
- Aelevated gonadotrophin releasing hormone (GnRH) production
- Belevated luteinising hormone production (LH)
- Cgonadotroph hyperplasia
- DAll of the possible answers
- ENone of these answers
6Prostaglandins normally exert their biological effects via:
- Anuclear hormone receptors
- Btyrosine kinase receptors
- Cimmunoglobulin receptors
- Dion channels
- EG-protein coupled receptors (GPCRs)
7Mutations in the Pit-1 gene could cause disruption in the development of:
- Asomatotroph and thyrotroph cells
- Bpancreatic b cells
- Cgonadotroph and thyrotroph cells
- Dsomatostatin neurons
- Epancreatic a cells
8The processing of which two peptide hormones requires the proconvertase enzymes, PC1 and PC2?:
- Ainsulin and adrenocorticotrophin hormone (ACTH)
- Binsulin and prolactin
- Cprolactin and somatostatin
- DACTH and prolactin
- Eprolactin and growth hormone (GH)
9What binds to unoccupied glucocorticoid receptors (GRs) to prevent their translocation to the nucleus?:
- Aheat shock proteins
- Blipid molecules
- Cmineralocorticoids
- Dother unoccupied GRs
- Eunoccupied mineralocorticoid receptors (MRs)
10What confounding issue renders the measurement of circulating cortisol inconclusive?:
- Acortisol is secreted at different levels throughout the day
- Bthe presence of binding proteins
- Cthyroxine cross-reacts in the cortisol radioimmunoassay
- Dinsufficient concentrations of cortisol are secreted for accurate measurement
- Ethe absence of binding proteins
11The major physiological regulator of aldosterone synthesis and secretion is:
- Athe renin-angiotensin system
- Bcatecholamine release from the adrenal medulla
- Coestradiol
- Dcortisol
- Ecalcium excretion
12Mutations in the orphan nuclear receptor Steroidogenic factor-1 (SF-1) gene can cause:
- Aabsent renal development
- Babsent pancreatic development
- Celevated luteinising hormone (LH) secretion
- Ddecreased PRL secretion
- Eabsent adrenal development
13Which two of the following peptide hormones are composed of less than 15 amino acids in their mature form?
- Ainsulin and growth hormone (GH)
- BGnRH and TRH
- Cthyrotrophin releasing hormone (TRH) and GH
- DGH and gonadotrophin releasing hormone (GnRH)
- EGnRH and insulin
14A receptor that couples to a Gas G-protein will directly activate:
- Atyrosine kinase activity
- Bprotein kinase G
- Cadenylyl cyclase activity
- Dprotein kinase C
- Enone of the above
15The proopiomelanocortin (POMC) gene encodes which of the following peptide hormones?:
- Aadrenocorticotrophin hormone (ACTH)
- Bmelanocyte stimulating hormone (MSH)
- CaMSH
- Dall of the answers
- Eb-Endorphin
16The range of temperatures in a species preferred optimum temperature zone (POTZ) is essential in the captive environment because:
- Areptiles are homeothermic
- Bnot all systems function optimally at the same temperature
- Creptiles are endothermic
- Dmales need a lower temperature for spermatogenesis
- Ehigher temperatures are necessary for hormone production
17Amphibians are considered to be ‘cold-blooded’ because the major influence on their body temperate is external. However this term is inappropriate and amphibians should be defined as:
- APoikilothermic
- BEndothermic
- CHomeothermic
- DWarm-blooded
- EHomothermic
18What makes up the posterior pituitary?
- APars nervosa known as the neurohypophysis
- BPars tuberalis, pars distalis and pars intermedia known as the adenohypophysis
- CPars tuberalis, pars distalis and pars intermedia known as the neurphypophysis
- DPars nervosa known as the adenohypophysis
19What makes up the anterior pituitary?
- APars tuberalis, pars distalis and pars intermedia known as the adenohypophysis
- BPars nervosa known as the neurohypophysis
- CPars tuberalis, pars distalis and pars intermedia known as the neurohypophysis
- DPars nervosa known as the adenohypophysis
20From what germ cell layers does the pars distalis and pars nervosa develop from respectively?
- AEctoderm and neuro-ectoderm
- BNeuro-ectoderm and ectoderm
- CMesoderm only
- DEndoderm only
21The adrenal gland releases aldosterone from which zona?
- AZona glomerulosa
- BZona fasciculata
- CZona reticularis
- DAdrena medulla
22The adrenal gland secretes cortisol primarily from which zone?
- AZona fasciiculata
- BZona glomerulosa
- CZone reticularis
- DAdrenal medulla
23The adrenal gland secretes the adrenal androgens from which zone?
- AZona reticularis
- BZona glomerulosa
- CZona fasciculata
- DAdrenal medulla
24The adrenal gland secretes epinephrine and norepinephrine from which zone?
- AAdrenal medulla
- BZona glomerulosa
- CZona fasciculata
- DZona reticularis
25Which chain in the glycoprotein peptide hormones are identical?
- AAlpha subunits
- BBeta subunits
26Which class of steroids is cortisol and aldosterone?
- ACorticosteroids (C21)
- BProgestagens (C21)
- CAndrogens (C19)
- DOestrogens (C18)
27The cholesterol enter mitochondria during steroid biosynthetic pathway from action of...?
- AStAR (Steroidogenic acute regulatory protein)
- BSteroidogenic Factor 1
- CHeat shock proteins
- DcAMP
28Which hormones are derived from tyrosine?
- AAdrenaline and noradrenaline
- BDopamine
- CT3/T4
- DAll of the above
29Which lipid soluble hormone(s) exert their effects on plasma membrane receptor?
- AProstaglandins and Leukotrienes (the Eicosanoids)
- BT3/T4
- CCortisol
- DAldosterone
30Aldosterone (mineralocorticoid) and Cortisol (Glucocorticoids) are structurally similar and so can bind to each other's receptors.
How is this overcome?- A11 beta hydroxyl steroid D enzyme converts cortisol to inactive cortisone which won't activate the aldosterone receptor
- B11 beta hydroxyl steroid D enzyme converts aldosterone to inactive aldostisone which won't activate the cortisol receptor
31The anabolic actions of cortisol involves what and occurs where?
- AGlycogenesis, gluconeogeneis and protein synthesis in the liver
- BGlycogenesis, gluconeogeneis and protein synthesis in muscle and fat cells
32The catabolic actions of cortisol involve what and occur where?
- AProtein breakdown and lipolyis in muscle and fat cells
- BProtein breakdown and lipolyis in brain
33Dexamethazone is used to test?
Inhibits ACTH from anterior pituitary and CRH from hypothalamus.- APrimary hyperadrenocorticism
- BPrimary Hyperaldosteronism
- CSecondary Hyperaldosteronism
- DCorticotrophenioma tumour
34Where are these hormones secreted from?
Oxytocin and ADH- APosterior pituitary
- BAnterior pituitary
- CHypothalamus
- DAdrenal gland
- EThyroid
35Where are these hormones secreted from?
LH & FSH, GH, TSH, Prolactin and ACTH- AAnterior pituitary hormone
- BPosterior pituitary hormone
- CHypothalamus
- DThyroid
- EAdrenal gland
36Out of all the hypothalmus hormone secretions which one is the only one classed as catecholamine hormone whilst all the others are peptide?
- ADopamine
- BGnRH
- CGHRH
- DSST
- ETRH
- FCRH
37The hormones of hypothalamus all act on GPCR.
- ATrue
- BFalse
38The posterior pituitary has no neural connections with hypothalamus and so hormones from the hypothalamus are transported via the hypothalamo-pituitary portal vessels
- ATrue
- BFalse
39Which hormone below is NOT released from the thyroid gland?
- ACalcitonin
- BTri-iodothryonine
- CThyroxine
- DPTH
40Which one of these transcription factors is involved with thyroid development?
- APax8
- BFoxe1
- CAll the answers
- DHhex
41The thyroid hormones are regulated to increase their activity by?
- APhosphorylation
- BSumoylation- binding sumoproteins to to the nuclear thyroid receptors
- CIncreased secretion
- DIncreased binding to thyroid binding proteins
42The thyroid hormones are regulated to decrease their activity by?
- APhosphorylation
- BSumoylation- binding sumoproeins to nuclear thyroid hormones
- CDecreased secretion
- DIncreased binding to thyroid binding proteins
43IgG binding to or near TSH receptors causing an increase in cAMP activating TSH signalling leading to hyperthyroidism is known as what?
- AGraves' disease
- BHashimoto's disease
- CAddison's disease
- DCushing's syndrome
44Thyroid hyperplasia and lymphocytic infiltration leading to loss of thyroid function leading to Hypothyroidism is known as what?
- AGrave's disease
- BHashimoto's disease
- CCushing's syndrome
- DAddison's disease
45Heat produced from metabolism:
- AEndothermy
- BHomeothermy
- CTachmetabolism
- DEctothermy
- EHeterothermy/ poikilothermy
- FBradymetabolism
46Constant body temperature:
- AHomeothermy
- BEndothermy
- CTachmetabolism
- DEctothermy
- EHeterothermy/poikilothermy
- FBradymetabolism
47High metabolism:
- ATachmetabolism
- BEndothermy
- CHomeothermy
- DEctothermy
- EHeterothermy/poikilothermy
- FBradymetabolism
48Heat from exogenous sources:
- AEctothermy
- BEndothermy
- CHomeothermy
- DTachmetabolism
- EHeterothermy/poikilothermy
- FBradymetabolism
49Body temperature fluctuates:
- AHeterothermy/poikilothermy
- BEndothermy
- CHomeothermy
- DTachmetabolism
- EEctothermy
- FBradymetabolism
50Low metabolism:
- ABradymetabolism
- BEctothermy
- CHeterothermy/poikilothermy
- DEndothermy
- EHomeothermy
- FTachmetabolism
51Whats the one main advantage Heterothermy/poikilothermys have over homeothermias?
- ANeed to eat less often
- BLonger duration of activity
- CCan perform actions throughout different times of day
- DProtection against infection as it is too hot for many pathogens such as fungi
52Stress leukogram blood test for someone with high cortisol will show what?
- AHigh neutrophils, low esoinophils, low lymphocytes and High platelets
- BLow neutrophils, low esoinophils, low lymphocytes and low platelets
- CHigh neutrophils, high esoinophils, low lymphocytes and low platelets
- DHigh neutrophils, low esoinophils, high lymphocytes and low platelets
- EHigh neutrophils, high esoinophils, high lymphocytes and high platelets
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- Principles and animal form and fucntion (Unit 4 Endocrine system) Quiz on Unit 4 Endocrine MCQ test, created by Jack Fawsitt on 05/12/2016.
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- Jack Fawsitt
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