Quiz
Introduction To Haemostasis
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Questions in this quiz (25)
1Primary Haemostasis = [blank_start]Formation of Platelet Plug[blank_end]
Secondary Haemostasis = [blank_start]Formation of Fibrin Clot[blank_end]- AFormation of Fibrin Clot
- BFormation of Platelet Plug
2Platelets are formed on the surface of which type of cell?
[blank_start]Megakaryocyte[blank_end]- AMegakaryocyte
3As a platelet has a lifespan of [blank_start]7-10 days[blank_end], a patient on e.g. aspirin should have this medication stopped this period of time before surgery to avoid any unnecessary bleeding.
- A7-10 days
- B10-14 days
- C14-21 days
4Platelets are formed on the surface of megakaryocytes which are found within the bone marrow
- ATrue
- BFalse
5Von Willebrand Factor binds to Factor [blank_start]VIII[blank_end] in the circulation. Without WVF the aforementioned factor would be broken down in the blood.
- AVIII
6Factor VIII is released from Von Willebrand Factor by action of [blank_start]Thrombin[blank_end] (Factor [blank_start]IIa[blank_end])
- AIIa
- BThrombin
7Von Willebrand factor also forms part of the platelet mesh that forms in response to bleeding, holding the platelets together.
- ATrue
- BFalse
8Reduced number of platelets in the blood is known as [blank_start]thrombocytopenia[blank_end]
- Athrombocytopenia
9The commonest inherited bleeding disorder is a deficiency of [blank_start]Von Willebrand Factor[blank_end]
- AVon Willebrand Factor
10Which usually results in a more serious bleed?
- APrimary Haemostasis failure
- BSecondary Haemostasis failure
11Failure of primary haemostasis typically causes which 3 of the following?
- AEpistaxis
- BConjunctival bleeding
- CMenorrhagia
- DIschaemic stroke
- ECoronary artery infarction
12If you were concerned about the failure of primary haemostasis you would check the [blank_start]platelet[blank_end] count in the blood.
- Aplatelet
13Coagulation Cascade (1):
Tissue Factor binds with Factor [blank_start]VIIa[blank_end]- AVIIa
14Coagulation Cascade (2):
TF-VIIa Complex activates Factor [blank_start]X[blank_end] to Factor [blank_start]Xa[blank_end].
In the meantime, TF-VIIa also activates Factor [blank_start]IX[blank_end] to Factor [blank_start]IXa[blank_end]. This Factor then binds with Factor [blank_start]VIIIa[blank_end] and this complex then also activates Factor [blank_start]X[blank_end] to Factor [blank_start]Xa[blank_end]- AXa
- BX
- CIX
- DIXa
- EVIIIa
- FX
- GXa
15Coagulation Cascade (3):
Factor Xa then binds with Factor [blank_start]Va[blank_end] to form the enzyme [blank_start]prothrombinase[blank_end], which facilitates the conversion of [blank_start]Prothrombin[blank_end] (Factor [blank_start]II[blank_end]) to [blank_start]Thrombin[blank_end] (Factor [blank_start]IIa[blank_end])- AProthrombin
- BII
- CThrombin
- DIIa
- Eprothrombinase
- FVa
16Coagulation Cascade (4):
Thrombin (Factor IIa) then goes about activating Factor [blank_start]VIII[blank_end] to Factor [blank_start]VIIIa[blank_end], in turn releasing it from its binding to [blank_start]Von Willebrand Factor[blank_end], whilst also activating Factor [blank_start]V[blank_end] to Factor [blank_start]Va[blank_end]- AV
- BVa
- CVon Willebrand Factor
- DVIIIa
- EVIII
17Coagulation Cascade (5):
The main function of Thrombin, however, is in the activation of [blank_start]Fibrinogen[blank_end] (Factor I) to [blank_start]Fibrin[blank_end] (Factor Ia).- AFibrin
- BFibrinogen
18Coagulation Cascade (6):
Finally, soluble Fibrin produced by thrombin-mediated activation is organised into crosslinked Fibrin by action of Factor [blank_start]VIIIa[blank_end]- AVIIIa
19Fibrin is broken down into Fibrin Degradation Products (e.g. D-dimers) via which enzyme?
[blank_start]Plasmin[blank_end]- APlasmin
20Plasminogen --> Plasmin is mediated by which enzyme, which is thus used clinically as a thrombolytic agent?
[blank_start]Tissue Plasminogen Activator[blank_end]- ATissue Plasminogen Activator
21Screening tests for Fibrin Clot Formation:
[blank_start]Prothrombin Time[blank_end]: Tests TF-VIIa complex activating factor X so that the Xa/Va complex (prothrombinase) can be produced.
[blank_start]Activated Partial Thromboplastin Time[blank_end]: Tests VIIIa/IXa complex activating Factor X so that the Xa/Va complex (prothrombinase) can be produced.- AActivated Partial Thromboplastin Time
- BProthrombin Time
22Anti-Thrombin III binds to ... thus inhibiting secondary haemostasis
- AThrombin (Factor IIa) only
- BThrombin (Factor IIa) & Prothrombinase (Xa/Va complex)
- CProthrombinase (Xa/Va complex) only
- DTF-VIIa & VIIIa/IXa complexes only
- EThrombin (Factor IIa), Prothrombinase (Xa/Va complex) & the TF-VIIa and VIIIa/IXa complexes
23Thrombin can bind to an endothelial cell forming thrombomodulin, which in turn activates Protein [blank_start]C[blank_end] and Protein [blank_start]S[blank_end] (give in alphabetical order).
- AS
- BC
24Proteins C & S affect which complexes?
- AProthrombinase (Xa/Va complex) only
- BProthrombinase (Xa/Va complex) & TF-VIIa complex
- CProthrombinase (Xa/Va complex) & VIIIa/IXa complex
25Deficiency of clotting factors is called [blank_start]haemophilia[blank_end]
Increased tendency to form clots is called [blank_start]thrombophilia[blank_end]- Athrombophilia
- Bhaemophilia
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- Honours Degree Medicine (Haematology - Week 2) Quiz on Introduction To Haemostasis , created by Matthew Coulson on 04/03/2019.
- Author
- Matthew Coulson
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- English
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