Quiz
Myeloma and Other Plasma Cell Disorders
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Questions in this quiz (28)
1Immunoglobulins are antibodies produced by B cells/Plasma cells that are made up of [blank_start]2[blank_end] heavy chains and [blank_start]2[blank_end] light chains
- A2
- B1
- C3
- D2
- E1
- F3
2Which of the immunoglobulins has a pentameric structure?
- AIgM
- BIgG
- CIgA
3Which of the immunoglobulins has a dimeric structure?
- AIgM
- BIgA
- CIgG
4Which of the immunoglobulins have monomeric structures?
- AIgM
- BIgG
- CIgA
- DIgE
- EIgD
5[blank_start]Plasma[blank_end] cells have an eccentric 'clock face nucleus' on H&E Stain
- APlasma
6Plasma cells are characterised by their [blank_start]open[blank_end] chromatin
- Aopen
- Bclosed
7Monoclonal immunoglobulins are all derived from clonal expansion of one single B cell. Monoclonal immunoglobulins are also known as [blank_start]paraproteins[blank_end]
- Aparaproteins
8Paraproteins = [blank_start]Monoclonal[blank_end] Immunoglobulins
- AMonoclonal
- BPolyclonal
9Paraproteins are a marker of an underlying clonal B cell disorder
- ATrue
- BFalse
10What is the best form of investigation for detecting Paraproteins
- AImmunophenotyping by Flow Cytometry
- BSerum Electrophoresis
- CFluorescence In-Situ Hybridisation
- DCell Morphology
11Paraproteins found on Serum Electrophoresis tend to present in the [blank_start]Gamma[blank_end] band
- AGamma
- BBeta
- CAlbumin
- DAlpha-1
- EAlpha-2
12After serum electrophoresis has been conducted to detect paraproteins, serum [blank_start]immunofixation[blank_end] should then be conducted in order to classify the abnormal protein band
- Aimmunofixation
13Bence Jones Protein is a monoclonal immunoglobulin light chain which is detected by [blank_start]urine[blank_end] electrophoresis
- Aurine
- Bserum
- Cbone marrow
- DCSF
14The presence of Bence Jones Protein in the urine is suggestive of which two of the following conditions?
- AMultiple Myeloma
- BWaldenström's Macroglobulinemia
- CMonoclonal Gammopathy of Undetermined Significance (MGUS)
- DAlpha heavy chain disease
- EAcute Lymphoblastic Leukaemia
15Which of the following is most common condition causative of paraproteinaemia?
- AMultiple Myeloma
- BMonoclonal gammopathy of undetermined significance (MGUS)
- CWaldenstrom's Macroglobulinemia
16Monoclonal gammopathy of undetermined significance (MGUS) is a benign (premalignant) condition which can predispose to Multiple Myeloma
- ATrue
- BFalse
17Myeloma causes [blank_start]renal[blank_end] failure and increased [blank_start]bone breakdown[blank_end]
- Abone breakdown
- Bblood pressure
- Cerythrocytosis
- Dsodium levels
- Erenal
- Fliver
- Gheart
18Myeloma is classified based on which type of monoclonal antibody is produced. What is the most common type of Myeloma?
- AIgG Myeloma
- BIgE Myeloma
- CIgA Myeloma
- DIgD Myeloma
- EIgM Myeloma
19Due to bone breakdown occurring as part of Myeloma, it also typically causes raised [blank_start]Calcium[blank_end] levels in the blood
- ACalcium
- BSodium
- CPotassium
- DPhosphate
20The paraproteins in Myeloma bring about renal failure by blocking the renal [blank_start]tublues[blank_end]
- Atubules
21Paraproteins blocking the renal tubules as part of Myeloma forms small aggregations leading to what is known as [blank_start]cast[blank_end] nephropathy
- Acast
22Myeloma tends to affect those in their [blank_start]60s[blank_end]
- A60s
- B40s
- C20s
- Dteens
23Levels of [blank_start]paraprotein[blank_end] in the blood should be monitored in order to monitor the response of a Myeloma patient to Chemotherapy.
- Aparaprotein
24Which of the following should be avoided in Myeloma patients?
- ANSAIDs
- BAmoxicillin
- CAntipsychotics
- DAntiemetics
- EParacetamol
25Which drug type should be given to myeloma patients in order to correct their hypercalcaemia and reduce their bone pain?
[blank_start]Bisphosphonates[blank_end]- ABisphosphonates
26Monoclonal gammopathy of undetermined significance (MGUS) can be diagnosed when there is a paraprotein level of [blank_start]<30g/l[blank_end] and a bone marrow plasma cell level of [blank_start]<10%[blank_end]. There must also be no evidence of any end organ damage (e.g. renal failure, bone marrow failure, etc)
- A<30g/l
- B<20g/l
- C<50g/l
- D<60g/l
- E<10%
- F<20%
- G<30%
- H<40%
- I<50%
27A plasma cell immunoglobulin disorder is suspected in a patient. When a sample from the patient was stained using Congo Red and placed under polarising light it showed an 'apple-green' birefringence. What condition is the patient suffering from?
[blank_start]AL Amyloidosis[blank_end]- AAL Amyloidosis
28Waldenstrom’s macroglobulinaemia is a condition which characteristically involves [blank_start]IgM[blank_end] Paraproteins
- AIgM
- BIgG
- CIgA
- DIgE
- EIgD
Information
- Description
- Multiple Myeloma, AL Amyloidosis, MGUS and Waldenstrom's Macroglobulinaemia
- Author
- Matthew Coulson
- Language
- English
- Views
- 20
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