Quiz
Ass 1.3. Nan
Questions in this quiz (58)
1 Which of the following is NOT an advantage of solution dosage form as compared to solid dosage form?
- AGreater Bioavailability
- BEase of Transportation
- CEase of Administration
- DPediatric Use
2Which of the following is true with regards to the solubility of a weak acid?
- ASolubility increases with decreasing pH
- BSolubility increases with increasing pH
- CSolubility decreases with increasing pH
- DSolubility remains constant with increasing pH
3A novel compound dissolves in water and the solution becomes cold. Which of the following will further increase the solubility of this compound in water?
- ADecrease in temperature
- BDecreased amount of water
- CIncrease in temperature
- DIncreased amount of novel compound
4__________ are dispersions of liquid drugs in liquid vehicles.
- ASuspension
- BEmulsion
- CColloid
- DGel
5Which of the following has the least aqueous solubility
- ACHCl3
- BCCl4
- CCH2Cl2
- DCH3Cl
6Syrup is a concentrated alcoholic solution with sweetener and medicinal agent ?
- ATrue
- BFalse
7Which of the following is not an example of Cosolvent system?
- AAromatic Elixir
- BIodine Tincture
- CAcacia Syrup
- DParegoric tincture
- AAromatic Elixir
8All of the following are advantages of Pharmaceutical solutions EXCEPT
- AEasier to swallow
- BGreater Bioavailability
- CMore stable than solid dosage forms
- DHomogenous uniform dosing is possible
9The two MAJOR factors affecting solubility are?
- ATemperature and agitation
- BpH and particle size
- CPolarity and agitation
- DTemperature and pH
10To determine the ratio of buffer components to add to a solution to maintain a given pH you should use which equation?
- ApH= pKa + log (salt/acid)
- BpHmax = pKa + Log [(St-Sa)/Sa]
- CB= change in B/ change in pH
- DSt= Sa(1+ [Ka/H])
11All of the following are generally true about Organic Compound Solubility EXCEPT:
- AMore carbon atoms decrease the aqueous solubility
- BHalogens decrease solubility
- CPolar groups increase solubility
- DLow melting point indicates low solubility
12Which of the following would be considered an ethanol/ water cosolvent system.
- AInverted syrup
- BMagic Mouthwash
- CParegoric
- DAcacia Syrup
13Which of the following is an example of a cosolvent?
- ASodium Acetate
- BOleic Acid
- CSodium Benzoate
- DSaccharin Sodium
14which of the following is NOT a force of attraction that affects dissolution?
- AIon-dipole
- BVan Der Waals
- CHydrogen Bonding
- DIonic Bonding
15Sedimentation increases with_______?
- AParticle size reduction
- BIncrease in viscosity of dispersion medium
- CIncrease in density of dispersed phase
- DIncrease in density of dispersion medium
16Which of the following is true when particle aize of an antibiotic powder is reduced from 50 micrometers to 5 micrometers?
- AHigher surface area, Lower surface energy
- BLower surface area,Higher surface energy
- CLower surface area, Lower surface energy
- DHigher surface area, higher surface energy
17Flocculation occurs due to stronger forces of attraction between the particles of a suspension.
- ATrue
- BFalse
18The Sedimentation Volume (F) for an ideal flocculated system is
- A0.5
- B1.0
- C0.7
- D0.3
19Which of the following is responsible for charge on a neutral particle surface when suspended in water?
- AAdsorption of OH-
- BAdsorption of H2O
- CParticle wetting
- DParticle agglomeration
20In an electrical double layer which layer is associated with the zeta potential?
- ABulk layer
- BDiffuse layer
- CSurface layer
- DStern layer
21Which of the following situations best represents a deflocculated system?
- AF=0.2
- BF=0.9
- CF=1.0
- DF=1.2
22Flocculation is observed at extreme (+)ve and (-)ve values of zeta potential.
- ATrue
- BFalse
23The structured vehicle approach is applicable to both flocculated and deflocculated particles.
- ATrue
- BFalse
24Which of the following best represents the flow of flocculated suspension?
- ANewtonian Flow
- BDilant Flow
- CPlastic Flow
- DPseudoplastic Flow
25In which of the following methods oil and emulsifier are mixed first followed by addition of water at once?
- AIn-situ soap method
- BEnglish Method
- CAuxiliary Method
- DContinental Method
- EBottle Method
26Skin permeation is a must for the component(s) of both medicated and non-medicated topical dosage forms.
- ATrue
- BFalse
27A major skin permeation pathway for small hydrophilic molecule is?
- ATrans appendageal
- BHair Follices
- CTranscellular
- DIntercellular
28Absorption bases are associated with all of the following except?
- AAnhydrous
- BAbsorb water
- CWater Washable
- DHydrous
- EOcclusive
29What is HFA?
- AHydroflouroalkane
- BHydroflorine Association
- CHow Far Away
- DHappy Friend Association
30Droplets decelerate as they leave the spray nozzle of a pressurized spray.
- ATrue
- BFalse
31pDMIs can be sprayed in any orientation
- ATrue
- BFalse
32All medical Aerosol products contain a propellant
- ATrue
- BFalse
33All nasal sprays deliver the same dose independent of the orientation in which they are used
- ATrue
- BFalse
34Which of the following is NOT an advantage of a topical antibiotic sprayed on the skin rather than delivered by a cream.
- AConvenient
- BMinimal contamination of unused product
- CAccurate dose metering
- DNo need to touch skin
- ESmaller particle size
35If inhaled, particles with a diameter of 6 micrometers would be expected to penetrate the respiratory system to the level of the:
- ABronchioles
- BAlveoli
- CNasal Cavity
- DThroat (pharynx)
36For which type(s) of aerosol system(s) will the pressure drop as the product is used?
- ACompressed gas system
- BThree- phase system
- CTwo-Phase system
- DB and C only
37Which part of the valve assembly of an aerosol is responsible for preventing leakage of the formulation from the container?
- AMounting Cap
- BActuator
- CGasket
- DHousing
38Which of the following is NOT an example of a "surface Spray" aerosol?
- ADermatological aerosols
- BPaint Sprays
- CHair Sprays
- DRoom deodorizers
39What is the FDA recommended alcohol content limit in liquid OTC drug product for children 6-12 years?
- A10%
- B1%
- C0.5%
- D5%
40Which of the following descriptive terms of relative solubility includes 12.5% w/v strength?
- AVery soluble
- BSoluble
- CSlightly soluble
- DFreely Soluble
41Which of the following groups on organic molecules will NOT increase water solubility?
- ACH2F
- BNH2
- CCOOH
- DSO3H
42Which of the following is the pharmaceutical advantage of elixirs over syrups as liquid dosage forms?
- AContains less sugar
- BDissolve ionized and unionized drugs
- CProvide faster drug absorption
- DAre better at masking the taste of drugs
43Which of the following minimum alcohol percentages is required in medicated syrups to prevent microbial growth?
- A5%
- B0.1%
- C15%
- D1%
44Water cannot dissolve which of the following organic compounds by intermolecular hydrogen bonds?
- AEsters
- BAlcohol
- CAcids
- DHydrocarbons
45Besides accurately and conveniently measuring dosage volume which of the following factors is important when making drug solutions for oral administration?
- AColor
- BBioavailability
- CStability
- DTaste
46Which of the following is an example of an ingredient in an organogel?
- ASodium alginate
- BHydrocarbon waxes
- CPolyethylene glycol
- DCarboxylmethylcellulose
47Which of the following describes the action of a flocculating agent in drug suspensions?
- AEnable loose interparticle attraction
- BDissolve the suspended particles
- CPrevent interparticle attraction
- DReduce the particle size
48Which of the following is a correct statement regarding inhalation drug products (aerosols)?
- AEach successive dose is slightly smaller as the pressure decreases with each actuation.
- BThe total quantity of accurate dose from a metered dose inhaler is limited by depletion of the liquid phase of the propellant
- CThe total quantity of accurate doses from a metered dose inhaler is limited by depletion of the active drug.
- Dchlorofluorocarbon are federally prohibited for use as propellants
49Which of the following blends of surfactants would favor a stable O/W emulsion?
- A0.5 parts Myrj 45 + 0.5 parts Brij 30
- B0.4 parts Span40 +0.6 parts Tween 20
- C0.6 parts span60 +0.4 parts Tween80
- D0.7 parts span80 + 0.3 parts Tween60
50Which of the following terms describes a fluid drug preparation that would increasingly flow more freely as it is agitated?
- APseudoplastic
- BPlastic
- CDilant
- DThixotropic
51Stoke's Law equation does NOT include which of the following factors?
- AInterparticle Attraction
- BFluid Density
- CParticle Diameter
- DGravitational Constant
52When treating a topical condition, all of the following are suitable criteria for selecting an ointment base for drug delivery EXCEPT:
- ADegree of Occlusion provided
- BTherapeutic systemic blood levels of drug
- CStability of drug in an ointment base
- DCharacteristics of the skin that will be treated.
53Which of the following is an example of a water soluble base
- AWhite ointment USP
- BLanolin USP
- CPolyehtylene Glycol Ointment USP
- DHydrophillic Ointment USP
54Which of the following is NOT an appropriate pharmacist counseling point to a patient before applying ophthalmic ointment?
- ATip of the tube should be placed in gentle contact with the conjunctival sac
- BPatient should wash and dry hands before application
- CImproperly handled ophthalmic products can lead to eye infection
- DAfter application blurred vision is normal and will likely occur
55Which of the following is FALSE regarding levigating agents which are used to reduce drug particle size?
- AGlycerin is an appropriate levigating agent for O/W bases
- BThe levigating agent must be physically and chemically compatible with the drug and the ointment base
- CThe drug for levigation should be soluble in the liquid used as the levegating agent
- DMineral oil is a good levigating agent for W/O ointment bases
56Which of the following TDDS products is permitted to be cut into smaller pieces for patient specific therapy?
- ANitro-Dur
- BNicoderm
- CDuragesic
- DFentanyl Patch
- EAll of the above
- FNone of the above
57All of the following factors predict favorable transdermal drug absorption for systemic therapy EXCEPT:
- AFull hydration of stratum corneum
- BA high aqueous solubility of the drug
- CMolecular weight of drug of about 100-400
- DA high partition coefficient of the drug
58Wearing a TDDS for longer than the approved duration can result in unsafe plasma drug concentration
- ATrue
- BFalse
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- Assessment 1.3 Nan Days
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- shadow_spiers
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