AntiFungal, Antiviral and Antimycobacerial Drugs- Pharmacology- 4th Year- PMU

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AntiFungal, Antiviral and Antimycobacerial Drugs- Pharmacology- 4th Year- PMU
Med Student
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Med Student
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3

Resumen del Recurso

Pregunta 1

Pregunta
Antifungals are:
Respuesta
  • tetracyclines
  • imidazoles
  • echinocandims
  • triazols

Pregunta 2

Pregunta
Synthetic antifungal drugs are
Respuesta
  • Nystatin
  • Itraconazole
  • Ketoconazole
  • Fluconazole

Pregunta 3

Pregunta
Antifungal antibiotics are:
Respuesta
  • Nystatin
  • Tetracycline
  • Gentamycin
  • Amphotericin B

Pregunta 4

Pregunta
Azoles:
Respuesta
  • are fungistatic
  • inhibit cell wall synthesis
  • inhibit ergosterol synthesis
  • inhibit hepatic CYP450 enzymes

Pregunta 5

Pregunta
lmidazoles are:
Respuesta
  • Fluconazole and ltraconazole
  • Miconazole and Econazole
  • Given topically
  • Given systematically

Pregunta 6

Pregunta
Ketoconazole is:
Respuesta
  • the only imidazole that can be given orally
  • used for treatment of bacterial skin infections
  • used topically for cutaneous fungal infections
  • used intravenously for treatment of systemic fungal infections

Pregunta 7

Pregunta
Fluconazole:
Respuesta
  • it is non- steroidal anti-inflammatory drug
  • is triazole antifungal drug
  • is administered orally or intravenously
  • is excreted mainly unchanged with the urine

Pregunta 8

Pregunta
ADRs of azole antifungals are:
Respuesta
  • hepatotoxicity
  • endocrine disorders
  • nephrotoxicity
  • nausea, vomiting

Pregunta 9

Pregunta
Point the correct statements for Nystatin:
Respuesta
  • has fungistatic activity
  • causes gastrointestinal disturbances
  • is effective against Trichomonas vaginalis
  • is effective against Candida species

Pregunta 10

Pregunta
ADRs of Amphoteracin B are:
Respuesta
  • renal impairment
  • hypokalemia
  • hypotension
  • liver impairment

Pregunta 11

Pregunta
Antiviral drugs act by following mechanisms
Respuesta
  • inhibition of viral “uncoating”
  • inhibition of viral DNA or RNA synthesis
  • inhibition of viral proteases
  • inhibition of viral penetration into the cell

Pregunta 12

Pregunta
Point out the correct statements for Aciclovir:
Respuesta
  • it inhibits viral DNA polymerase
  • it is used for “treatment of herpesvirus infections
  • it inhibits neuraminidase enzyme
  • can be applied topically, orally or intravenously

Pregunta 13

Pregunta
ADRs of Aciclovir are:
Respuesta
  • hepatotoxicity
  • renal impairment
  • local irritation
  • encephalopathy (at high i.v. doses)

Pregunta 14

Pregunta
Drugs for prevention and treatment of flu are:
Respuesta
  • Aciclovir (Zovirax)
  • Amantadin (Symmetrel)
  • Rimantadin (Flumadine)
  • Oseltamivir (Tamiflu)

Pregunta 15

Pregunta
Mechanism of action of Oseltamivir (Tamiflu) is
Respuesta
  • interference with the function of the viral M2 protein
  • inhibition of specific neuraminidase enzyme
  • inhibition of reverse transcriptases
  • inhibition of proteases

Pregunta 16

Pregunta
For Amantadine and Rimantadine is true:
Respuesta
  • resistance can develop rapidly
  • they are effective against both type A and type B influenza
  • they are effective against type A influenza viruses
  • they interfere with the function of the viral M2 protein and block uncoating of the Virus particles

Pregunta 17

Pregunta
Mechanisms of action of drugs for treatment of HIV infection are:
Respuesta
  • inhibition of reverse transcriptase
  • inhibition of HIV protease
  • inhibition of HIV entry into the host cell
  • inhibition of the insertion of proviral DNA. into the host cell genome

Pregunta 18

Pregunta
Point out the correct statements for Zidovudin;
Respuesta
  • it blocks HIV reverse transcriptase
  • it blocks HIV protease
  • it is a nucleoside analogue
  • it can cause anemia and neutropenia

Pregunta 19

Pregunta
ADRS of Nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs) are:
Respuesta
  • peripheral neuropathy
  • pancreatitis
  • polymyositis
  • glaucoma

Pregunta 20

Pregunta
HIV protease inhibitors are:
Respuesta
  • Zidovudin
  • Indinavir
  • Ritonavir
  • Aciclovir

Pregunta 21

Pregunta
For HIV protease inhibitors is true:
Respuesta
  • protease inhibition prevents maturation of the viral particles
  • they are enzyme inducers
  • they are enzyme inhibitors
  • they are combined with other antiretroviral drugs in the treatment of HIV infection

Pregunta 22

Pregunta
ADRs of HIV protease inhibitors are:
Respuesta
  • hyperlipidaemia
  • insulin resistance and hyperglycaemia
  • hypoglycaemia
  • fat redistribution

Pregunta 23

Pregunta
Inhibitor of both hepatitis B virus (HBV) and HIV reverse transcriptases is:
Respuesta
  • Zidovudin
  • Lamivudin
  • Aciclovir
  • lndinavir

Pregunta 24

Pregunta
Protease inhibitor for treatment of chronic hepatitis C infection is:
Respuesta
  • Aciclovir
  • Telaprevir
  • Zidovudin
  • Oseltamivir

Pregunta 25

Pregunta
Antimycobacterial drugs are:
Respuesta
  • Rifampicin
  • Isoniazid
  • Ethambutol
  • Amoxicillin

Pregunta 26

Pregunta
Rifampicin (Rifampin):
Respuesta
  • is bactericidal antibiotic with antimycobacterial activity
  • is antiviral drug
  • is broad spectrum antibiotic
  • is enzyme inducer

Pregunta 27

Pregunta
Mechanism of action of Rifampicin (Rifampin) is
Respuesta
  • inhibition of cell wall synthesis
  • inhibition of 50 S ribosomal subunit
  • inhibition of DNA-dependent RNA polymerase
  • increased cell membrane permeability

Pregunta 28

Pregunta
ADRs of Rifampicin (Rifampin) are:
Respuesta
  • heart failure
  • orange-red color of urine and other secretions
  • hepatotoxicity
  • hypoglycaemia

Pregunta 29

Pregunta
Point out the correct statements for lsoniazid:
Respuesta
  • inhibits the synthesis of essential for mycobacteria mycolic acid
  • it is metabolized by, acetylation
  • it is specific for treatment of M. Tuberculosis
  • it is active against broad spectrum of bacteria

Pregunta 30

Pregunta
ADRs of lsoniazld are:
Respuesta
  • renal impairment
  • peripheral neuropathy
  • convulsions
  • hepatitis

Pregunta 31

Pregunta
lsoniazid-induced peripheral neuropathy can be avoided by:
Respuesta
  • supplementation with vitamin B1
  • supplementation with vitamin A
  • supplementation with vitamin B6
  • supplementation with vitamin B12

Pregunta 32

Pregunta
ADRs of Pyrazinamide are:
Respuesta
  • hepatotoxicity
  • arrhythmia
  • hyperuricaemia
  • hypoglycaemia

Pregunta 33

Pregunta
Ethambutol:
Respuesta
  • is bacteriostatic antimycobacterial drug
  • may cause liver failure
  • may cause optic neuritis
  • inhibits synthesis of the mycobacterial cell wall
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