2523712
Descripción
Test por offersforalice, actualizado hace más de 1 año
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Creado por offersforalice
hace alrededor de 9 años
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Pregunta 1
Pregunta
Choose the word or phrase from the list below that best completes this sentence.
Pharmacokinetics can be described as ________________________
Respuesta
-
how the drug elicits it's effect in the body.
-
how the body handles a drug.
-
the composition of a drug.
-
the way in which a drug should be stored.
Pregunta 2
Pregunta
Choose the word or phrase from the list below that best completes this sentence.
Drugs may act locally or systemically. Systemically means that the drug must enter ___________________ in order to be delivered to its site of action.
Respuesta
-
the brain
-
the circulation
-
the lymph nodes
-
the heart
Pregunta 3
Pregunta
Which equation can you use to calculate the amount of a drug that reaches the systemic circulation?
Respuesta
-
F x dose
-
F/dose
-
F - dose
-
F + (2 x dose)
Pregunta 4
Pregunta
Choose the word or phrase from the list below that best completes this sentence.
Drugs administered as an IV injection have a bioavailability of _________.
Respuesta
-
100
-
10
-
1.0
-
0.1
Pregunta 5
Pregunta
What words make up the acronym ADME?
Respuesta
-
Administration
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Absorption
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Distribution
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Dissolving
-
Making
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Metabolism
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Exit
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Excretion
Pregunta 6
Pregunta
Choose the word or phrase from the list below that best completes this sentence.
Generally in absorption, drugs move from an area of high concentration to a low concentration via ______________
Respuesta
-
osmosis.
-
active transport.
-
passive diffusion.
Pregunta 7
Pregunta
Choose the word or phrase from the list below that best completes this sentence.
When drugs are being absorbed from an area of their low concentration to a higher concentration, they move by _____________
Respuesta
-
active transport.
-
osmosis.
-
passive diffusion.
Pregunta 8
Pregunta
Choose the word or phrase from the list below that best completes this sentence.
Cell membranes are composed of a double layer of ____________________
Respuesta
-
proteins.
-
sugars.
-
phospholipids.
-
ions.
Pregunta 9
Pregunta
Water soluble drugs pass cell membranes easier than lipid soluble drugs.
Respuesta
- True
- False
Pregunta 10
Pregunta
Choose the word or phrase from the list below that best completes this sentence.
The more _______________ a drug, the easier it is for the drug to be absorbed from the small intestine into the circulation.
Respuesta
-
lipid soluble
-
water soluble
Pregunta 11
Pregunta
Un-ionised drugs are lipid soluble.
What does un-ionised mean?
Respuesta
-
The drug carries no charge.
-
The drug is negatively charged.
-
The drug is positively charged.
-
The molecule contains two opposing charges.
Pregunta 12
Pregunta
Choose the word or phrase from the list below that best completes this sentence.
The small intestine has a large surface area due to it's large number of __________.
Respuesta
-
villi
-
cillia
-
hairs
-
cells
Pregunta 13
Pregunta
Choose the word or phrase from the list below that best completes this sentence.
The larger the surface area for drug absorption, the _______ the absorption.
Respuesta
-
slower
-
quicker
Pregunta 14
Pregunta
Where does most drug absorption take place?
Respuesta
-
Stomach
-
Small Intestine
-
Large Intestine
-
Colon
Pregunta 15
Pregunta
The presence of food after a meal will slow gastric emptying.
Respuesta
- True
- False
Pregunta 16
Pregunta
Sometimes drugs are prescribed to be taken with food. Why might this be?
Respuesta
-
To lessen the side effects of a drug by preventing large concentrations from entering systemic circulation at the same time, ensuring a more gradual absorption due to gastric emptying.
-
To mask the bad taste of a drug that is taken orally.
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To prevent local side effects, like irritation of the stomach lining, caused by drugs like NSAIDs.
Pregunta 17
Pregunta
Choose the word or phrase from the list below that best completes this sentence.
Some drugs are absorbed from the small intestine into the _____________ and are transported directly into the liver.
Respuesta
-
renal portal vein
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cranial portal vein
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hepatic portal vein
Pregunta 18
Pregunta
What is the name of the process by which a drug is fully or partially metabolised by the liver, before entering the systemic circulation?
Respuesta
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First pass metabolism
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Liver/drug degradation
-
First past metabolism
Pregunta 19
Pregunta
Hypomotility of the GI tract may result in lower concentrations of drug entering the circulation.
Respuesta
- True
- False
Pregunta 20
Pregunta
Blood flow affects absorption.
Respuesta
- True
- False
Pregunta 21
Pregunta
Choose the word or phrase from the list below that best completes this sentence.
A drug must reach it's site of action in ______________, in order to exert it's effect.
Respuesta
-
an adequate concentration
-
a membrane bound vesicle
-
a salt solution
Pregunta 22
Pregunta
Blood flow affects distribution.
Respuesta
- True
- False
Pregunta 23
Pregunta
Blood flow affects distribution. Organs that have high perfusion, e.g. heart, therefore receive drugs slowly.
Respuesta
- True
- False
Pregunta 24
Pregunta
Choose the word or phrase from the list below that best completes this sentence.
Only ________ drug can cross plasma membranes and therefore exert an effect.
Respuesta
-
free
-
plasma protein bound
-
albumin bound
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