2687344
Pregunta 1
Pregunta
Parenteral administration of drugs describes what?
Respuesta
-
Orally/Rectally
-
Intravenously/Intramuscularly
-
Inhaled
Pregunta 2
Pregunta
Percutaneous administration of drugs describes what?
Respuesta
-
Inhaled
-
Orally/Rectally
-
Intravenously/Intramuscularly
Pregunta 3
Pregunta
Enteral administration of drugs describes what?
Respuesta
-
Orally/Rectally
-
Intravenously/Intramuscularly
-
Inhaled
Pregunta 4
Pregunta
What is an advantage of the parenteral route of administration?
Respuesta
-
Easy to administer on unconscious patients
-
Reaches the blood stream first and avoids first pass metabolism
Pregunta 5
Pregunta
What is an advantage of percutaneous administration of drugs?
Respuesta
-
Easy to administer on unconscious patients
-
Reaches the blood stream first and avoids first pass metabolism
Pregunta 6
Pregunta
Repeated doses of general anaesthetic such as thiopental can cause a fatal dose because of accumulation, or "tissue binding" in adipose tissue.
Respuesta
- True
- False
Pregunta 7
Pregunta
1st pass metabolism describes what phenomenon?
Respuesta
-
When the concentration of a drug available to the systemic circulation (it's bioavailability) is significantly reduced because it is metabolised by the liver before it reaches the systemic circulation.
-
When the concentration of a drug available to the systemic circulation (it's bioavailability) is significantly increased because it is metabolised by the liver before it reaches the systemic circulation.
Pregunta 8
Pregunta
1st pass metabolism can be useful for activating pre-cursor drugs such as L-dopa into dopamine.
Respuesta
- True
- False
Pregunta 9
Pregunta
Steady state in pharmacology describes what?
Respuesta
-
Drug absorption = Drug elimination
-
Drug absorption > Drug elimination
-
Drug absorption < Drug elimination
Pregunta 10
Pregunta
What is the plasma half life of a drug?
Respuesta
-
The time for half of the drug to be eliminated from the blood
-
The time it takes for a drug to lose half of its pharmacological activity
Pregunta 11
Pregunta
What is meant by the hydrophobic effect?
Respuesta
-
Amino acids with non-polar (hydrophobic) groups arrange themselves on the inside of a protein and vice versa.
-
Amino acids with non-polar (hydrophilic) groups arrange themselves on the inside of a protein and vice versa.
-
Amino acids with polar (hydrophobic) groups arrange themselves on the inside of a protein and vice versa.
-
Amino acids with polar (hydrophilic) groups arrange themselves on the inside of a protein and vice versa.
Pregunta 12
Pregunta
Haemoglobin in sickle cell is dysfunctional as a result of an incorrect hydrophobic effect.
Respuesta
- True
- False
Pregunta 13
Pregunta
What is the primary structure of a protein?
Respuesta
-
Sequence of amino acids
-
Folding into an alpha helix or beta pleated sheet
-
Folding of a polypeptide chain and addition of prosthetic groups
-
Many polypeptide chains
Pregunta 14
Pregunta
What is the secondary structure of a protein?
Respuesta
-
Sequence of amino acids
-
Folding into an alpha helix or beta pleated sheet
-
Folding of a polypeptide chain and addition of prosthetic groups
-
Many polypeptide chains
Pregunta 15
Pregunta
What is the tertiary structure of a protein?
Respuesta
-
Sequence of amino acids
-
Folding into an alpha helix or beta pleated sheet
-
Folding of a polypeptide chain and addition of prosthetic groups
-
Many polypeptide chains
Pregunta 16
Pregunta
What is the quaternary structure of a protein?
Respuesta
-
Sequence of amino acids
-
Folding into an alpha helix or beta pleated sheet
-
Folding of a polypeptide chain and addition of prosthetic groups
-
Many polypeptide chains
Pregunta 17
Pregunta
The two weakly ionising groups of an amino acid are?
Respuesta
-
Amino group
-
Carboxyl group
-
R group
Pregunta 18
Pregunta
With a pKa value of 9.7, and the equation NH3+ -> NH2 + H+ , at pH 9 what species will dominate?
Respuesta
-
NH2 + H+
-
NH3+
Pregunta 19
Pregunta
What graph correctly depicts the dose response curve?
Respuesta
Pregunta 20
Pregunta
Response is proportional to occupancy
Respuesta
- True
- False
Pregunta 21
Pregunta
The maximum response cannot be attained when a competitive reversible antagonist is present.
Respuesta
- True
- False
Pregunta 22
Pregunta
In the presence of a competitive reversible antagonist, how is the dose response curve shifted?
Respuesta
-
Left
-
Right
Pregunta 23
Pregunta
An irreversible antagonist means that the maximum response can never be reached.
Respuesta
- True
- False
Pregunta 24
Pregunta
How is the dose response curve shifted in the presence of an irreversible antagonist?
Respuesta
-
Down
-
Up
Pregunta 25
Pregunta
Irreversible antagonists cause a decrease in the maximal response when spare receptors are not present.
Respuesta
- True
- False
Pregunta 26
Pregunta
Prolonged exposure to a drug reduces the bodies response to it.
Respuesta
- True
- False
Pregunta 27
Pregunta
Without spare receptors, non-competitive antagonists can reduce the maximal response (Emax).
Respuesta
- True
- False
Pregunta 28
Pregunta
When a non-competitive antagonist is used in the presence of spare receptors, the dose response curve shifts left.
Respuesta
- True
- False
Pregunta 29
Pregunta
Non-competitive antagonists do not compete for the agonist binding site.
Respuesta
- True
- False
Pregunta 30
Pregunta
Irreversible antagonists reduce the number of available receptors.
Respuesta
- True
- False
Pregunta 31
Pregunta
The dose response curve of an irreversible agonist is shifted down because the maximal response is decreased.
Respuesta
- True
- False
Pregunta 32
Pregunta
Select common ways that cells regulate their functions via receptors
Respuesta
-
Altering membrane potential
-
Phosphorylating enzymes
-
Altered gene expression in cells
Pregunta 33
Pregunta
An integral tyrosine kinase can be activated and then phosphorylates a target molecule such as an enzyme.
Respuesta
- True
- False
Pregunta 34
Pregunta
Lipophobic molecules can cross the PM and NM and bind to steroid receptors e.g. to boost transcription.
Respuesta
- True
- False
Pregunta 35
Pregunta
G-protein coupled receptors have ATPase activity that turns their activity off.
Respuesta
- True
- False
Pregunta 36
Pregunta
Cytokine receptors activate JAK that can phosphorylate targets and lead to signal pathways.
Respuesta
- True
- False
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