Test
Tumor Suppressors
Preguntas del test (22)
1What is the role of the Rb Susceptibility gene?
- ANuclear transcription factor
- BNuclear phosphatases
- CNuclear phosphorylases
2What protein does Rb bind to?
- AE2F
- BFF2
- CEF2
3What is the role of the protein bound to Rb?
- ATranscription factor
- BKinase
- CPhosphatase
4What are the target genes of the Rb bound protein?
- AdNTP producing genes
- BTranscription factor producing genes
- CGrowth factor producing genes
5How is Rb phosphorylated and deactivated?
- ABy Cyclin
- BBy CDK
- CBy a cyclin/CDK dimer
6What protein phosphorylates CDK?
- ACAK
- BCAD
- CCAB
7Which forms first during G1?
- ACDK/Cyclin D
- BCDK/Cyclin E
8What causes the production of Cyclin/CDK E &D?
- AJun Activity
- BAP1 Activity
- CMyc Activity
9Which is required to activate E2F?
- ACyclin/CDK D
- BCyclin/CDK E
- CBoth
- DNeither
10Name 3 CDK inhibitors
- Ap13
- Bp21
- Cp12
- Dp16
- Ep27
- Fp19
11Which of the following binds to CDK, & twists its head to block the active site?
- Ap16
- Bp12
- Cp19
12Which of the following bind to cdk with cyclin and physically block the active site?
- Ap21
- Bp27
- Cp19
13How are the CDK inhibitors controlled?
- APhosphorylation & degredation
- BPhosphorylation & activation
14How long is the bp sequence p53 binds to?
- A10 bp
- B12 bp
- C15 bp
15Put the following p53 domains in order A- Signalling Domain B- Damaged DNA binding domain C-Oligomerization Domain D- Activation Domain E- DNA binding domain
- AD-A-E-C-B
- BD-A-C-E-B
- CA-D-C-E-B
- DB-A-D-E-C
16How does p53 work in its active form?
- AAs a monomer
- BAs a dimer
- CAs a tetramer
17What does p53 bind to when active?
- ATATA boxes
- BE-boxes
- CDamaged DNA
18What can cause the activation of p53?
- AAcetylation
- BPhosphorylation
- CIonising radiation
19What does p53 do if activated in G1?
- ARepairs DNA
- BReverts the cell back to G0
- CForces cell through mitotic cycle
20What happens if p53 is activated after G1?
- ABax is transcribed- it initiates apoptosis
- BBax is transcribed- It initiates S phase
- CBax is transcribed- It inhibits M phase
21Where do mutations causing non-function tend to occur in p53?
- AThe DNA binding domain
- BThe damaged DNA binding domain
- CThe signalling domain
22How is p53 removed from the cell?
- AMDM2
- BMDM
- CMDM1
Información
- Descripción
- Year 2 Test sobre Tumor Suppressors, creado por gina_evans0312 el 03/12/2013.
- Autor
- gina_evans0312
- Idioma
- English
- Visitas
- 589
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