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chirality

Sam Watkins 12 preguntas

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Preguntas del test (12)

  1. 1enantiomers are non identical mirror images with a plane of symettry
    1. AVerdadero
    2. BFalso
  2. 2enantiomers are a pair of stereoisomers that are non identical mirror images of eachother
    1. AVerdadero
    2. BFalso
  3. 3diastereoisomers are
    1. Aa pair of non identical stereoisomers that are not mirror images of eachother
    2. Ba pair of non identical stereoisomers that are mirror images of eachother
    3. Ca pair of identical mirror images with a plane of symettry
  4. 4when describing chiral centres.. (select all that are true)
    1. AR/S classifies a chiral centre by the groups around it
    2. BD/L classifies a chiral centre by comparison to a reference compound glyceraldehyde
    3. Cd/l classifies a molecule by the direction it rotates polarised light d is clockwise
    4. D+/- is the same as R/S. R = + S = -
  5. 5Biosynthesis (synthesis of molecules in a biological system) is often stereoselective
    1. AVerdadero
    2. BFalso
  6. 6Chiral synthesis in the laboratory is often very [blank_start]difficult[blank_end]. It is even harder to scale up to industrial scale. Two approaches to obtaining pure chiral molecules are [blank_start]Chiral separation[blank_end] (use a physical method e.g chromatography to separate the desired stereoisomer from a mixture) and [blank_start]The Chiral Pool[blank_end] (use a starting material that already contains a chriral centre.)
    1. Adifficult
    2. Bstraightforward
    3. Cfast
    4. DChiral separation
    5. Echiral synthesis
    6. FHPLC/MS
    7. GThe Chiral Pool
    8. HThe chemical pool
    9. Ichiral separation
    10. Jchiral splitting
  7. 7about 25% of drugs are administered as a racemate - an equal mixture of stereoisomers
    1. AVerdadero
    2. BFalso
  8. 8some drugs are given as a single isomer which means a larger dose is required
    1. AVerdadero
    2. BFalso
  9. 9which of the following is FALSE
    1. Afor a pair of stereoisomers the one with the greater activity is the eutomer
    2. Bfor a pair of stereoisomers the one with the lesser activity is the distomer
    3. Cthe ratio between the distomer and the eutomer is the disumic ratio
  10. 10select which apply about the ADME of stereoisomers:
    1. Aduring ABSORPTION by transmembrane proteins stereoisomers of chiral drugs can absorb differently
    2. Bduring ABSORPTION by passive diffusion stereoisomers of chiral drugs absorb differently
    3. CDISTRIBUTION leads to the stereoisomers having different effects because they bind to the plasma proteins
    4. DMETABOLISM causes stereoisomers to be the broken down same as the same enzymes are used for both R and S forms of the drug

Información

Descripción
chirality in drug design
Idioma
English
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