5397094
Descripción
Test por Sam Watkins, actualizado hace más de 1 año
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Creado por Sam Watkins
hace alrededor de 8 años
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Pregunta 1
Pregunta
enantiomers are non identical mirror images with a plane of symettry
Respuesta
- True
- False
Pregunta 2
Pregunta
enantiomers are a pair of stereoisomers that are non identical mirror images of eachother
Respuesta
- True
- False
Pregunta 3
Pregunta
diastereoisomers are
Respuesta
-
a pair of non identical stereoisomers that are not mirror images of eachother
-
a pair of non identical stereoisomers that are mirror images of eachother
-
a pair of identical mirror images with a plane of symettry
Pregunta 4
Pregunta
when describing chiral centres.. (select all that are true)
Respuesta
-
R/S classifies a chiral centre by the groups around it
-
D/L classifies a chiral centre by comparison to a reference compound glyceraldehyde
-
d/l classifies a molecule by the direction it rotates polarised light d is clockwise
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+/- is the same as R/S. R = + S = -
Pregunta 5
Pregunta
Biosynthesis (synthesis of molecules in a biological system) is often stereoselective
Respuesta
- True
- False
Pregunta 6
Pregunta
Chiral synthesis in the laboratory is often very [blank_start]difficult[blank_end]. It is even harder to scale up to industrial scale. Two approaches to obtaining pure chiral molecules are [blank_start]Chiral separation[blank_end] (use a physical method e.g chromatography to separate the desired stereoisomer from a mixture) and [blank_start]The Chiral Pool[blank_end] (use a starting material that already contains a chriral centre.)
Respuesta
-
difficult
-
straightforward
-
fast
-
Chiral separation
-
chiral synthesis
-
HPLC/MS
-
The Chiral Pool
-
The chemical pool
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chiral separation
-
chiral splitting
Pregunta 7
Pregunta
about 25% of drugs are administered as a racemate - an equal mixture of stereoisomers
Respuesta
- True
- False
Pregunta 8
Pregunta
some drugs are given as a single isomer which means a larger dose is required
Respuesta
- True
- False
Pregunta 9
Pregunta
which of the following is FALSE
Respuesta
-
for a pair of stereoisomers the one with the greater activity is the eutomer
-
for a pair of stereoisomers the one with the lesser activity is the distomer
-
the ratio between the distomer and the eutomer is the disumic ratio
Pregunta 10
Pregunta
select which apply about the ADME of stereoisomers:
Respuesta
-
during ABSORPTION by transmembrane proteins stereoisomers of chiral drugs can absorb differently
-
during ABSORPTION by passive diffusion stereoisomers of chiral drugs absorb differently
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DISTRIBUTION leads to the stereoisomers having different effects because they bind to the plasma proteins
-
METABOLISM causes stereoisomers to be the broken down same as the same enzymes are used for both R and S forms of the drug
Pregunta 11
Pregunta
The development of a [blank_start]single[blank_end] isomer drug from a previously marketed [blank_start]racemate[blank_end] is known as the [blank_start]chiral switch[blank_end]
Respuesta
-
single
-
R-
-
multi
-
racemate
-
eutomer
-
tablet
-
distomer
-
chiral switch
-
chiral pool
-
chiral centre
Pregunta 12
Pregunta
which are advantages of the chiral switch?
Respuesta
-
improved biological activity
-
opportunity to market a new product
-
reduced side effects
-
simpler pharmacokinetics
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