¡GoConqr estrena diseño! Cuéntanos qué te parece.

Regístrate gratis

Fichas

HLA and MHC: classes, genes and structure

bluedancer06 Inglés 72 fichas

Class I MHC

Fichas del conjunto (72)

  1. 1HLAHUMAN LEUKOCYTE ANTIGEN
  2. 2MHCMAJOR HISTOCOMPATIBILITY COMPLEX
  3. 3MHCdetermine whether transplanted tissue is histocompatible or thus accepted or recognized as foreign or rejected
  4. 4T-cell activationantigen+ MHC molecule
  5. 5Location for the genes coding for MHC moleculeshort arm Chromosome 6
  6. 6Gene product of Class IA,B,C
  7. 7Genes coding for Class IIDP, DQ, DR
  8. 8Genes coding for Class IIIComplement proteins, TNF(cytokine)
  9. 9Allelesalternate forms of a gene that codes for slightly different varieties of the same product
  10. 10Alleles of HLA-A580
  11. 11Alleles of HLA-B921
  12. 12Alleles of HLA-C312
  13. 13Codominantall alleles than an individual inherit codes for products expressed on cells
  14. 14MHC haplotypeeach inherited chromosome consist of A,B,C,DQ,DR,DP
  15. 15Tissue Distribution of Class Iall nucleated cells
  16. 16Highest level of expression in Class Ilymphocytes
  17. 17Lowest level or undetected expressions of Class Iliver hepatocytes, neural cells, muscle cells, sperm
  18. 18Gene product with the lowest level in Class IHLA-C
  19. 19Gene product most important to match for transplantation in Class IHLA-A and HLA-B
  20. 20Composition of each class I antigenglycoprotein dimer
  21. 21MW of Alpha chain in class I45,000
  22. 22MW of B2-microglobulin light chain12,000
  23. 23Alpha 1, 2,3 are inserted into the cell membrane viahydrophobic transmembrane system
  24. 24No. of amino acid of the external domain90 amino acids
  25. 25No. of amino acid as anchor in Class I30 amino acids
  26. 26Domain of class I that does not penetrate cell membraneB2- microglobulin
  27. 27Domains of class I that forms the binding site for antigen recognitionalpha 1 and alpha 2
  28. 28No. of amino acid that binding site can hold in Class I8 and 10 amino acids
  29. 29Domains where most polymorphism resideAlpha 1 and alpha 2
  30. 30Class I is recognized bCytotoxic T-cells (CD8+)
  31. 31Domain where CD 8 reacts toalpha 3
  32. 32—Class I MHCClass I MHC
  33. 33—Class II MHCClass II MHC
  34. 34Non-classical class I antigensE,F,G
  35. 35Non-classical domains in class I not expressed on cell membrane and do not function in antigen recognitionE and F
  36. 36Non-classical class I antigen expressed on cell membraneG antigen
  37. 37Cells where G antigens are expressedTrophoblast cells
  38. 38Function of G antigensprotects placental tissue from the action of NK cells
  39. 39Peptide bound MHC class Iendogeneously synthesized
  40. 40Function of MHC class Ieliminates abnormal host cells by cytotoxic T cells
  41. 41Tissue distribution of Class IIAPC cells
  42. 42APC cells are:B-lymphocytes, monocytes, macrophages, dendritic cells
  43. 43gene product with the highest level in class IIDR gene
  44. 44most highly polymorphic class IIDR Beta gene
  45. 45MW of alpha chain in class II33,000
  46. 46MW of Beta chain in class II27,000
  47. 47Domain that forms the peptide binding site in Class IIalpha 1 and beta 1
  48. 48Non-classical domains in class II geneDM, DN, DO
  49. 49Main role of MHC antigento bind peptides within celles and transport them to the plasma membrane where T-cells can recognize them
  50. 50phenomenon where T-cells can recognize MHC antigenAntigen Presentation
  51. 51Class II are recognized byHelper T-cells (CD 4+)
  52. 52Peptide bound in class IIexogeneously processed
  53. 53Class I bind tovirus and tumors and certain parasitic antigen
  54. 54Rough Endoplastic Reticulumsynthesis of Class I and Class II
  55. 55Calnexinmolecule where newly synthesized Alpha chains freely bind to
  56. 56keeps alpha chain folded while it awaits binding of Beta2-microglobulinCalnexin
  57. 57helps stabilize calnexin once it is releasedcalreticulin,tapasin, ERp57
  58. 58proteins that fail to fold correctlyDefective Ribosomal Product
  59. 59Proteosomesdigest defective proteins
  60. 60TAP 1 and TAP 2transport proteins from cytoplasm to the ER
  61. 61Most potent activator of T-cellsDendritic cells
  62. 62excellent for capturing and digesting exogenous antigenDendritic cells
  63. 63prevent interaction of the binding site with any endogenous peptide in the ERinvariant chain
  64. 64helps bring alpha and beta chains together in the ERinvariant chain
  65. 65moves alpha and beta chains out throught the Golgi A. to endocytic vesicles where digested antigen is foundinvariant chain
  66. 66where the class II molecule is transported toendosomal compartment
  67. 67degraded products of invariant chain that are attached to the peptide binding cleftinvariant chain peptide
  68. 68Mediates the reaction by removing the CLIP fragmentsHLA-DM
  69. 69No.of amino acids that can bind to the class II13- 18
  70. 70how many amino acids provide the major contact point in class II7-10 amino acids
  71. 71Compositions of the trimolecular complex in ClassII MHCantigen-Class II- Tcell (CD4+)
  72. 72recruits and triggers B-cell response, resulting in antibody formationT helper cells

Información

Descripción
Fichas sobre Sin título, creado por bluedancer06 el 22/01/2015.
Creado por
bluedancer06
Visitas
9
Valoración

Más sobre MHC and Antigen Presentation

Escríbenos

¿Sobre qué es tu mensaje?

¿Qué te parece el nuevo diseño?

¿Te gusta?