Fichas
Ageing
Fichas del conjunto (9)
- 1Give three reasons why women live longer than men-Women have lower iron levels due to oestrogen levels. Iron form damaging free radicals.
-Young men engage in risky behaviour
-2X chromosomes makes it less likely that some deleterious mutations on X chromosome are expressed. - 2Which 6 mechanism factors cause the decline in the function of various bodily systems with age?-Genetically programmed cessation of mitosis
-Damage to the body's DNA
-Breakdown in accuracy of protein synthesis
-Changes in neuroendocrine function
-Decline in immune function
-Increased cellular free radical injury - 3What changes to cells are associated with aging?-Cell loss especially in amitotic tissue i.e. corneal endothelium and loss of skeletal/smooth muscle i.e. wasting of iris dilator muscle which accounts for senile miosis
-Changes in cellular organelles i.e. mitochondria and ER deteriorate
-Accumulation of lipofuscin - 4What is lipofuscin and how does it affect us in aging?-Accumulation of lipofuscin (Residues of lysosomal digestion) in cells i.e. RPE-lysosmes breakdown of outer segment, liver, kidney, etc...
- 5What is AGEs and how does it affect us in aging?-Accumulation of Advanced glycation end products (AGEs) which cause cross-linking between proteins like collagen and crystallines causing loss of elasticity in arteries and cataract.
- 6How is DNA affected during aging?-Irreversible DNA damage. When DNA divides, the ends of the chromosome are lost. The ends of the chromosomes are called telomeres. Telomeres do not code for proteins. As we age, the length of the telomeres decrease.
- 7What happens to elastic tissue with age?-Elastic tissue changes i.e. loss of elasticity in arteries
- 8Why does collagen decrease with age?-Increased enzymes that destroy collagen
- 9What other 5 things happen to an aging person?-Changes in cartilage and loss of bone tissue.
-Loss of hair mass and pigment
-Reproductive system changes-Menopause
-Multisensory deterioration
-Immune system decline
Información
- Descripción
- Bachelors Degree General pathology & eye disease Fichas sobre Ageing, creado por krwanabe el 15/12/2015.
- Creado por
- krwanabe
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