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9/27 Protein Structures
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- 1PRIMARY STRUCTURE Composition? Order? N/C Polar or Nonpolar? Average length and range? Final?-Chain of amino acids not folded yet
-N terminus to C terminus
-Polar because each end is differnt
-Average 300 amino acids; Range 20-1000+
-Never the final structure - 2PROTEIN FOLDING Why we don't know?Some side chains hydrophobic and some hydrophilic so how does it pack all of that good stuff into one box?
- 3SECONDARY STRUCTURE Options?Stable way for it to exist
-Alpha helix
-B sheet
-Random coil - 4ALPHA HELIX Where is the main chain? Peptide bond? Where the HBs at? Who is NEVER here? How many per turn? Minimum aa?-On dee inside
-Amino group's hydrogen + carboxyl group's oxygen = hydrogen bond
-HB only in main chain
-Proline and H2O banned for life - 5BETA SHEETS Made of? Two orientations? What aa are at the turns? Pattern?-Beta Strands (at least 2 with a turn)
-Parallel & Antiparallel (most common)
-Pro Gly Val (Ala Leu Ile)
-Side chains alternate: up down up down
npnp nnnn pppp - 6DISULFIDE BOND Who's involved? Polarity? Strength? Common? What issss it?-Cysteine
-In the bond it is nonpolar
-The strongest; stabilizing
-2to3 in each protein
-A salt bridge/ionic bond: these two polar uncharged babies wanna interact in the hydrophobic center
-Between secondary & tertiary
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- BIOL 24 Fichas sobre 9/27 Protein Structures , creado por lkjaoi kaooi el 02/12/2016.
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- lkjaoi kaooi
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