HPV Genome & Colonisation

Pregunta	Respuesta
Genome Type	ds DNA
Size	Small
Envelope	None
Location of Replication (Type of cell)	Differentiating Epithelium
No of Open Reading Frames	Several
Variation in ORF Expression	8-10 vary in early/late stages of infection
ORF Variation	Differentiate according to different promoters/splicing
Use of Machinery	Uses cells own machinery
HPV16 Infection	Basal layer of cervix wall, which is differentiating
HPV16 Entry	Accesses via microabrasions
Proteins for Entry	Cell Surface Integrins & Haperine Sulphate Proteoglycans
Inside the Nucleus- Replication System	Replicates once per cell cycle along with the cell
Inside the Nucleus- Expression of Viral Proteins	Alter cell growth, causing a wart
Terminal Differentiation of the Host Cell	Causes viral particle production, which are then shed
Terminal Differentiation of the Host Cell (Growth)	Cell growth is abnormal, may progress to cancer, may not

Resumen del Recurso

	Creado por gina_evans0312 hace alrededor de 10 años