HPV

Nicole Neumann
Mind Map by Nicole Neumann, updated more than 1 year ago
Nicole Neumann
Created by Nicole Neumann over 4 years ago
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Description

HPV test

Resource summary

HPV
  1. 8k bp circular DNA
    1. ORFs
      1. Early onset genes
        1. E1
          1. replicates viral episomes
          2. E2
            1. replication + transcription
              1. regulates E6/E7
              2. E4
                1. Viral maturation + release
                2. E5
                  1. host cell proliferation
                    1. inhibits immune response?
                    2. E6
                      1. p53 inactivation
                        1. uncontrolled cell cycle
                      2. E7
                        1. pRB inactivation
                          1. uncontrolled cell cycle
                            1. E7+pRB => E2F
                              1. p16INK4
                                1. ICC biomarker
                        2. Late onset genes
                          1. L1
                            1. major capsid protein
                            2. L2
                              1. minor capsid protein
                        3. HPV types
                          1. high risk
                            1. HPV 16
                              1. dominates 57% total
                              2. HPV 18
                                1. 16% SCC
                                  1. dominates AdCA
                                2. low risk
                                  1. HPV 6 & 11
                                  2. host cell DNA integration
                                    1. persistent HPV infection
                                      1. mutations
                                      2. host cell DNA polymerase
                                    2. HPV vaccine
                                      1. Gardasil & Cervarix
                                        1. cross immunity
                                          1. virus like particles
                                            1. type specific
                                            2. L1 origin
                                            3. CIN
                                              1. CIN1
                                                1. 1/3 N/C
                                                  1. superficial/intermediate
                                                  2. CIN2
                                                    1. 2/3 N/C
                                                      1. intermediate/parabasal
                                                        1. medium clustering
                                                      2. CIN3
                                                        1. 2/3+ N/C
                                                          1. parabasal/basal
                                                            1. grapes
                                                              1. clustering
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