RNA Viruses

ravi shah
Mind Map by ravi shah, updated more than 1 year ago
ravi shah
Created by ravi shah over 6 years ago
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Virology Mind Map on RNA Viruses, created by ravi shah on 06/16/2013.
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RNA Viruses
1 Positive Sense ss

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  • quick note - arboviruses use ticks, mosquitoes, and flies to infect - include toga, flavi, and bunyaviridae 
1.1 Picornavirus
1.1.1 Enterovirus

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  • mcc of aseptic meningitis especially in kids remember fungal meningitis mcc is cryptococcal
1.1.1.1 Rhinovirus

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  • most common cause of hospitalizations in children. second mcc of bronchiolitis vaccine not feasible common cold.
1.1.1.2 Coxsackie

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  • cav - herpangina (EV7) - always on posterior end of mouth (herpes leaves lesions on anterior mouth); exanthem and enanthem stuff CA16 - hand foot mouth (ev71) cbv - myocarditis and pericarditis
1.1.1.3 Poliovirus

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  • 1 2 3  2 is pretty much gone. ev71 also cause polio. fecal oral. vaccines - opv ipv (we use ipv-inactivated) opv can cause disease (live)
1.1.1.4 Echovirus
1.1.2 Hepatovirus

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  • hep a vaccine preventable.  not that bad.
1.1.3 Parechovirus
1.1.4 Kobuvirus

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  • aiichi - diarrhea
1.2 Coronavirus

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  • sars mucosally restricted new outbreak in saudi arabia 5/2013 mainly causes respiratory ilness; can cause GI issues in infants. no vaccine.
1.3 Flaviviridae

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  • ixodes ticks - encephalitis these all cause encephalitis and hemorrhagic or normal fever.
1.3.1 Japanese Encephalitis Virus Group

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  • JEV - vaccine preventable St. louis encephalitis West nile virus
1.3.2 Yellow Fever Virus

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  • vaccine preventable. can be pretty darn serious. black vomitus
1.3.3 Dengue Fever

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  • 4 serotypes. lifelong immunity if you get it. SOME cross reactivity.  no vaccine. 4 types of fever and rash: undifferentiated, classical hemorrhagic dengue shock
1.3.4 Hepacivirus - Hep c
1.4 Astrovirus

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  • diarrhea. adenovirus 41 40 also cause diarrhea
1.5 Calicivirus

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  • smaller than rotavirus in size.
1.5.1 Norovirus

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  • fluids and electrolytes. less severe than rota in children watery diarrhea.just wash your hands.cruise ship virus
1.6 Togaviridae
1.6.1 Alphaviridae

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  • old world - chikungunya new world - WEEV, EEEV, VEEV no treatment. just supportive. essentially - chikungunya = rash
1.6.2 Rubivirus

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  • rubella - mmr live vaccine. cataracts cardiac problems not an arbovirus - spread person to person congenital - dangerous during 1 tm of pregnancy only.
2 Negative sense ss
2.1 Orthomyxoviridae

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  • segmented boar
2.1.1 Influenza A B C

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  • Na inhibitors - oseltamivir, zanamivir (>7 years old; inhaled, works better than oseltamivir) M2 ion channel inh (type A only) -  amantidine, rimantidine; current strains aren't susceptible. all HA's transmitted through water fowl parabasic region - makes virus "high path"
2.2 Paromyxoviridae
2.2.1 Mucosally restricted
2.2.1.1 Parainfluenza

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  • croup steeple sign. NOT epiglottitis (HITB) odd years have outbreaks use steroids to prevent closing of trachea
2.2.1.2 hMPV
2.2.1.3 RSV

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  • number one cause of bronchiolitis try ribavirin but really use synagis (mAB) need 10x more antibody for nose infection than lung infection.
2.2.2 Systemic
2.2.2.1 Morbillivirus - measles

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  • koplik's spots rash everywhere very infectious - can be lethal mmr - vaccine.
2.2.2.2 rubulavirus - mumps

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  • parotitis (can be any gland really) isolate individual.  mmr - live vaccine.
2.3 Rhabdoviridae

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  • Rabies - vaccine 3 times before exposure. causes unstoppable encephalitis. bullet shaped virus. negri bodies. in texas - skunks and bats. 
2.4 Filoviridae

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  • fruit bats hemorrhagic fever
2.4.1 Marburgvirus
2.4.2 Ebolavirus
2.5 Bunyaviridae

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  • segmented boar
2.5.1 Bunyavirus

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  • California encephalitis lacross
2.5.2 Hantavirus

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  • HFRS - hantaan and seoul use ribavirin HPS - sin nombre virus. deer mouse and cotton rat. variants named by location. progresses quickly.
2.5.3 Phlebovirus

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  • sandfly. rift valley fever
2.5.4 Nairovirus

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  • tick borne crimean congo hemorrhagic fever use ribavirin for cchf
2.6 Deltavirus

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  • hep d?
3 Ambisense
3.1 Arenaviridae

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  • segmented boar
3.1.1 LCM

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  • aseptic meningitis
3.1.2 Lassa Fever

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  • hemorrhagic nausea, vomiting, diarrhea use ribavirin
4 double stranded
4.1 Reoviridae

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  • segmented boar
4.1.1 rotavirus

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  • watery diarrhea. 2 live vaccines; intussusception risk number 1 cause of diarrhea in developing countries. destroy the villi after 12 hours as seen on biopsy.
4.1.2 coltivirus

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  • colorado tick fever
4.1.3 reovirus
4.1.4 orbivirus
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