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Ageing Brain

Eleni Blakemore Ageing Brain (PS3061) Inglés 16 fichas

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  1. 1Patridge (2014)Ageing is co-morbid to cardiovascular disease, dementia, cancer, diabetes
  2. 2McCay (1935)The first to show that the ageing process can be slowed down
    Reduce calorie intake by 20% in rodents = decrease ageing by 20%
  3. 3Patridge (2010)Found the same results as McCay but in primates
  4. 4Partridge (2014)Reducing IIS + TOR pathway activity = increase in lifespan and health in a variety of species
  5. 5Cohen et al. (2009)Reducing IIS pathway activity in a mouse model of Alzheimers reduced behavioural symptoms and biomarkers in the brain of the disease
  6. 6Ornish et al. (2013)Lifestyle changes can increase telomere length in cancer patients
  7. 7Early Embryonic Development (Z, C, B, M, B, G)Zygote, cleavage, blastomere, morula, blastocyst (blastula), gastrula
  8. 8Neural Tube DevelopmentPlate, Groove, Tube
  9. 9Kitada & Dezawa (2012)Stem cells could have a therapeutic potential for Parkinson's Disease: neural stem cells and embryonic stem cells - can protect damages tissues and can generate into dopamine neurones
  10. 10Yamasaki et al. (2007)Stem cells therapeutic potential for Alzheimer's Disease: neural stem cells transplanted into brain of transgenic mouse model survive, migrate, differentiate and improve memory
  11. 11Dodd, Jessel & Placzek (1998)The neural plate is induced by the notochord, floor plate and roof plate of the mesodermal layer
  12. 12Ulloa & Marti (2009)Wnt & Sonic Hedgehog are the main transcription factors in the mesoderm
  13. 13Herrup & Stuer (1999)Radial glial cell act like a ladder in cell migration
  14. 14Inside-first, outside-last layeringCells leaving later migrate past the older neurons to the outermost cortex
  15. 15Fazeli & Walsh (1996)Aggregation is guided by cell-adhesion molecules located on the surface of the cells + bind to molecules on other cells
  16. 16What are the 3 hypotheses of axon growth?Chemoaffinity, blueprint and topographic gradient

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Ageing Brain (PS3061) Fichas sobre Ageing Brain, creado por Eleni Blakemore el 11/04/2017.
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Eleni Blakemore
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