Wound healing 1st intention

Rapid activation of coagulation pathways

Formation of blood clot

Release of VEGF

Scab Formation

Neutrophils at margin of wound clearing the debris

within 24 hrs

Both edges, endothelial cells migrate & proliferate

within 24 - 48 hrs

Neutrophils -> macrophages

Day 3

Epithelial cells continue to proliferate

Nearing normal thickness of epithelium

New leaky vessels formed

Day 5

Fibroblasts produce ECM

Epidermis recovers its full thickness

"Blanching" process

2nd week

Scar comprises a cellular CT & covered with normal epithelium

End of 1st month