4005181
The Bohr effect
- It describes the
effect that an
increasing
concentration of
carbon dioxide has
on the haemoglobin.
(in respiring tissues)
- ~carbon dioxide enters
the RBC forming carbonic
acid, which dissociates to
release hydrogen ions.
- ~these hydrogen
ions affect the pH of
the cytoplasm,
making it more acidic
- ~changes in pH can affect
the tertiary structure of the
Hb =increase acidity reduces
the affinity of Hb for O2.
- =Hb unable to hold as much
O2, & O2 is released from the
oxyhaemoglobin to tissues
- =Hb unable to hold as much
O2, & O2 is released from the
oxyhaemoglobin to tissues
- ~changes in pH can affect
the tertiary structure of the
Hb =increase acidity reduces
the affinity of Hb for O2.
- ~these hydrogen
ions affect the pH of
the cytoplasm,
making it more acidic
- ~carbon dioxide enters
the RBC forming carbonic
acid, which dissociates to
release hydrogen ions.
- CO2 lowers the affinity
of Hb for O2. O2 will
dissociate more easily.
- With a higher pCO2 the oxygen
association/dissociation curve
moves to the right. This is because
CO2 increases the dissociation of
oxyhaemoglobin to O2 + Hb
- With a higher pCO2 the oxygen
association/dissociation curve
moves to the right. This is because
CO2 increases the dissociation of
oxyhaemoglobin to O2 + Hb
- So in tissues where respiration is
taking place (muscles), CO2 is
produced. =CO2 transport to occur
& H+ to bind to Hb to make
haemoglobonic acid.
- This process results in O2
being released, & less O2
being able to associate
- So, when more CO2 is
present, Hb becomes less
saturated with O2 = change in
curve (RIGHT & DOWNWARDS)
=Bohr shift.
- This Bohr effect = more O2
release where more CO2 is
produced in respiration ~just
what the muscles need for
aerobic respiration to continue.
- This Bohr effect = more O2
release where more CO2 is
produced in respiration ~just
what the muscles need for
aerobic respiration to continue.
- So, when more CO2 is
present, Hb becomes less
saturated with O2 = change in
curve (RIGHT & DOWNWARDS)
=Bohr shift.
- This process results in O2
being released, & less O2
being able to associate
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