Nucleic Acids

Nucleic Acids

1. What is DNA/RNA Made of?

   • 2. Nucleobase
     • Purines
       • Adenine (A) Guanine (G)
       • Adenine (A) Guanine (G)
     • Pyrimidines
       • cytosine (C) Uracil (U)
       • cytosine (C) Thymine (T)
   • 3. Nucleotides
     • Product of phospho group at 5' carbon (TP-triphosphate) (DP-diphosphate)
     • Formula: Nuc-side + d/ + mono/di/tri d--deoxy DP--diphosphate TP--triphosphate
       • dAMP dADP dATP dGMP dGDP dGTP dCMP dCDP dTMP dTDP dTTP
       • AMP ADP ATP GMP GDP GTP CMP CDP CTP UMP UDP UTP
   • 1. 5 carbon sugar
   • +
     • Nucleoside-- combination of a nucleobase and pentose
       • DO-Adenosine, DO-guanosine, DO-cytidine, DO-thymidine
       • Adenosine Guanosine Cytidine Uridine

2. Cyclic Nucleotide Derivatives

3. DNA

   • DNA vs. RNA
   • Circular vs Linear DNA
   • DNA Superstructure

4. RNA

   • RNA
     • mRNA
     • tRNA
     • rRNA
     • snRNA and scRNA

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