L10 Protein binding

1. 1Protein binding is the [blank_start]reversible[blank_end] interaction of a drug with proteins in the [blank_start]plasma[blank_end]. Almost all drugs are bound to plasma [blank_start]proteins[blank_end] to some extent. Only the [blank_start]unbound[blank_end] drug is available to interact with receptors or can be [blank_start]eliminated[blank_end]. The rates of drug binding are very [blank_start]rapid[blank_end] (milliseconds).

   1. Areversible
   2. Bplasma
   3. Cproteins
   4. Dunbound
   5. Eeliminated
   6. Frapid
2. 2Which of these is not a drug binding protein?

   1. AAlbumin
   2. BSpecific protein types (e.g. thyroxine binding globulin etc)
   3. CLipoproteins
   4. D1-acid-glycoprotein
   5. EErythrocytes
3. 3Choose the incorrect statement about albumin.

   1. AGenerally basic drugs bind more readily to albumin.
   2. BThere are two main binding sites on albumin (sites I and II)
   3. CType I substrates include warfarin, sulphonamides, NSAIDs, valproate
   4. DType II substrates include penicillins and benzodiazepines
   5. EEach albumin molecule has at least 6 distinct binding sites for drugs and endogenous compounds
4. 4Binding to α1-acid-glycoprotein is quantitatively less important, the concentrations are typically [blank_start]1/100th[blank_end] that of albumin. This is a [blank_start]reactive[blank_end] protein that may increase several fold in the presence of acute [blank_start]inflammatory[blank_end] conditions. It mostly binds [blank_start]basic[blank_end] drugs (e.g. lignocaine).

   1. A1/100th
   2. Breactive
   3. Cinflammatory
   4. Dbasic
   5. E1/10th
   6. Facidic
5. 5Irreversible binding is less common and results in inactivation of the drug, e.g. cisplatin.

   1. AVerdadero
   2. BFalso
6. 6For a few drugs the clinically used doses may be sufficiently large to [blank_start]saturate[blank_end] the protein binding sites for the drug, e.g [blank_start]valproate[blank_end], some [blank_start]beta-lactam[blank_end] antibiotics, and corticosteroids. Therefore the [blank_start]free[blank_end] (unbound) concentration for these drug may be much [blank_start]greater[blank_end] than expected.

   1. Asaturate
   2. Bvalproate
   3. Cbeta-lactam
   4. Dfree
   5. Egreater
7. 7The free fraction is the [blank_start]free concentration[blank_end] of a drug divided by the [blank_start]total concentration[blank_end] of the drug(free and protein bound combined). Altered protein binding (which may be from [blank_start]decreased[blank_end] number of binding sites; e.g. due to aging, or decreased apparent [blank_start]binding affinity[blank_end]) is clinically irrelevant in [blank_start]most[blank_end] cases. This is because reduced protein binding causes:
   - [blank_start]increased[blank_end] free fraction
   - [blank_start]unchanged[blank_end] free concentration
   - [blank_start]reduced[blank_end] total concentration
   And the free concentration is the value of importance.
   
   
   

   1. Afree concentration
   2. Btotal concentration
   3. Cdecreased
   4. Dbinding affinity
   5. Emost
   6. Fincreased
   7. Gunchanged
   8. Hreduced

Descripción

PHCY310 Test sobre L10 Protein binding, creado por Mer Scott el 07/04/2019.

Autor

Mer Scott

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English

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10

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Creado el 7 abr 2019 · actualizado el 7 abr 2019

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phcy310

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