PHARM - Exam 1

1. 1These three beta blockers are
   Relative Cardioselectivity: ++
   Partial Agonist Activity (ISA): 0

   1. AAtenolol (Tenormin), Bisoprolol (Zebeta), Betaxolol (Kerlone)
   2. BMetaprolol (Lopressor), Nadolol (Corgard), Timolol (Blocadren)
   3. CCarteolol (Cartol), Penbutolol (Levatol), Pindolol (Visken)
   4. DNadolol (Corgard), Bisoprolol (Zebeta), Betaxolol (Kerlone)
2. 2This beta blocker has:
   Relative Cardioselectivity: +
   Partial Agonist Activity (ISA): 0

   1. AMetaprolol (Lopressor)
   2. BPropanolol (Inderal)
   3. CPenbutolol (Levatol)
   4. DPindolol (Visken)
3. 3These three beta blockers have zero cardioselectivity and partial agonist (ISA) activity

   1. ANadolol, Propanolol, Timolol
   2. BAcebutolol, Carteolol, Penbutolol
   3. CPindolol, Nadolol, Metaprolol
   4. DBetaxolol, Propanolol, Penbutolol
4. 4This beta blocker has:
   Relative Cardioselectivity: ++
   Partial Agonist Activity (ISA): +

   1. AAcebutolol (Sectral)
   2. BPenbutolol (Levatol)
   3. CMetaprolol (Lopressor)
   4. DTimolol (Blocadren)
5. 5These beta blockers have zero cardioselectivity, but do have ISA activity:

   1. ACarteolol (Cartol), Penbutolol (Levatol), Pindolol (Visken)
   2. BPenbutolol (Levatol), Metaprolol (Lopressor), Atenolol (Tormin)
   3. CPindolol (Visken), Atenolol (Tormin), Acebutolol (Sectral)
   4. DAcebutolol (Sectral), Nadolol (Corgard), Pindolol (Visken)
6. 6Which enzyme deficiency leads to poor metabolism of phenytoin (Dilantin), phenobarbital, omeprazole (Prilosec), citalopram, sertraline, clopidogrel, and others?

   1. ACYP2C19
   2. BCYP2D6
   3. CCYP1A2
   4. DCYP3A4
7. 7CYP2C19 deficiency leads to poor metabolism of:

   1. APhenytoin (Dilantin)
   2. BPhenobarbital
   3. COmeprazole (Prilosec)
   4. DCitalopram
   5. ESertraline
   6. FRifampin
   7. GMetoprolol
   8. HTheophylline
   9. IClopidogrel
8. 8Increased levels of this CYP450 enzyme can lead to opioid overdose:

   1. ACYP2D6
   2. BCYP2C19
   3. CCYP1A2
   4. DCYP3A4
9. 9The following drugs are metabolized by CYP2D6 to active metabolites:

   1. Atramadol
   2. Bhydrocodone
   3. Coxycodone
   4. Dverapamil
   5. Esertraline
   6. Fbeta blockers
   7. Gantidepressants
   8. Hrifampin
10. 10This CYP450 enzyme is induced by rifampin, a TB antibiotic. It increases levels of theophylline, causing it's serum levels to go down.

    1. ACYP1A2
    2. BCYP3A4
    3. CCYP2C19
    4. DCYP2D6

11. 11This CYP450 enzyme is inhibited by Ritonavir (Norvir). Sometimes it is added to lopinavir (Kaltera) to boost serum levels in patients with HIV.

    1. ACYP3A4
    2. BCYP2C19
    3. CCYP2D6
    4. DCYP1A2
12. 12This CYP450 enzyme metabolizes Simvastatin:

    1. ACYP3A4
    2. BCYP2C19
    3. CCYP2D6
    4. DCYP1A2
13. 13This CYP450 enzyme is decreased within 24 hrs. by administration of rifampin, and decreased up to 1 week with phenobarbital administration. It also metabolizes carbamazepine, a potent enzyme inducer:

    1. ACYP2C9
    2. BCYP1A2
    3. CCYP2D6
    4. DCYP3A4
14. 14Resistant hypertension is failure to achieve desired blood pressure after using [blank_start]3[blank_end] different drugs from [blank_start]3[blank_end] different classes

    1. A3
    2. B3
15. 15Target organ damage from high blood pressure can affect the following systems:

    1. Acardiac system
    2. Bcerebrovascular system
    3. Cperipheral vascular system
    4. Drenal system
    5. Eretinopathy
    6. Fcentral nervous system
    7. Ghepatic system
16. 16Organs affected by neurotransmitters are known as [blank_start]effector organs[blank_end].

    1. Aeffector organs
17. 17These Alpha receptors are located on postsynaptic nerve endings: [blank_start]a1[blank_end]

    1. Aa1
18. 18a1 receptors function to:

    1. Aconstrict smooth muscle
    2. Bincrease peripheral vascular resistance
    3. Cincrease BP
    4. Dincrease bladder sphincter pressure
    5. Eincrease HR
    6. Fincrease myocardial contractility
19. 19These Alpha receptors are located on presynaptic nerve endings and pancreas beta cells and allow for feedback inhibiton of norepinephrine: [blank_start]a2[blank_end]

    1. Aa2
20. 20b1 receptors are located in heart muscle and function to:

    1. Aincrease HR
    2. Blipolysis
    3. Cincrease myocardial contractility
    4. Dconstrict smooth muscle
    5. Eincrease BP
    6. Fincrease bladder sphincter pressure
21. 21b2 receptors are located in lung, periphery, and uterus and function to:

    1. Avasodilate
    2. Bbronchodilate
    3. Crelax uterine smooth muscle
    4. Dconstrict smooth muscle
    5. Eincrease BP
    6. Fincrease HR

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Selectivity of beta blockers

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